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475 related items for PubMed ID: 29018094

  • 1. Substrate-induced conformational changes in the nucleotide-binding domains of lipid bilayer-associated P-glycoprotein during ATP hydrolysis.
    Zoghbi ME, Mok L, Swartz DJ, Singh A, Fendley GA, Urbatsch IL, Altenberg GA.
    J Biol Chem; 2017 Dec 15; 292(50):20412-20424. PubMed ID: 29018094
    [Abstract] [Full Text] [Related]

  • 2. Cooperativity between verapamil and ATP bound to the efflux transporter P-glycoprotein.
    Ledwitch KV, Gibbs ME, Barnes RW, Roberts AG.
    Biochem Pharmacol; 2016 Oct 15; 118():96-108. PubMed ID: 27531061
    [Abstract] [Full Text] [Related]

  • 3. The Lipid Bilayer Modulates the Structure and Function of an ATP-binding Cassette Exporter.
    Zoghbi ME, Cooper RS, Altenberg GA.
    J Biol Chem; 2016 Feb 26; 291(9):4453-61. PubMed ID: 26725230
    [Abstract] [Full Text] [Related]

  • 4. Differential Coupling of Binding, ATP Hydrolysis, and Transport of Fluorescent Probes with P-Glycoprotein in Lipid Nanodiscs.
    Li MJ, Nath A, Atkins WM.
    Biochemistry; 2017 May 16; 56(19):2506-2517. PubMed ID: 28441502
    [Abstract] [Full Text] [Related]

  • 5. Luminescence resonance energy transfer spectroscopy of ATP-binding cassette proteins.
    Zoghbi ME, Altenberg GA.
    Biochim Biophys Acta Biomembr; 2018 Apr 16; 1860(4):854-867. PubMed ID: 28801111
    [Abstract] [Full Text] [Related]

  • 6. Dynamic ligand-induced conformational rearrangements in P-glycoprotein as probed by fluorescence resonance energy transfer spectroscopy.
    Verhalen B, Ernst S, Börsch M, Wilkens S.
    J Biol Chem; 2012 Jan 06; 287(2):1112-27. PubMed ID: 22086917
    [Abstract] [Full Text] [Related]

  • 7. In vivo FRET analyses reveal a role of ATP hydrolysis-associated conformational changes in human P-glycoprotein.
    Futamata R, Ogasawara F, Ichikawa T, Kodan A, Kimura Y, Kioka N, Ueda K.
    J Biol Chem; 2020 Apr 10; 295(15):5002-5011. PubMed ID: 32111736
    [Abstract] [Full Text] [Related]

  • 8. Allosteric Role of Substrate Occupancy Toward the Alignment of P-glycoprotein Nucleotide Binding Domains.
    Pan L, Aller SG.
    Sci Rep; 2018 Oct 02; 8(1):14643. PubMed ID: 30279588
    [Abstract] [Full Text] [Related]

  • 9. Cysteines introduced into extracellular loops 1 and 4 of human P-glycoprotein that are close only in the open conformation spontaneously form a disulfide bond that inhibits drug efflux and ATPase activity.
    Loo TW, Clarke DM.
    J Biol Chem; 2014 Sep 05; 289(36):24749-58. PubMed ID: 25053414
    [Abstract] [Full Text] [Related]

  • 10. Interactions and cooperativity between P-glycoprotein structural domains determined by thermal unfolding provides insights into its solution structure and function.
    Yang Z, Zhou Q, Mok L, Singh A, Swartz DJ, Urbatsch IL, Brouillette CG.
    Biochim Biophys Acta Biomembr; 2017 Jan 05; 1859(1):48-60. PubMed ID: 27783926
    [Abstract] [Full Text] [Related]

  • 11. Probing native metal ion association sites through quenching of fluorophores in the nucleotide-binding domains of the ABC transporter MsbA.
    Tatsumi D, Nanatani K, Koike Y, Kamagata K, Takahashi S, Konno A, Furuta T, Sakurai M, Uozumi N.
    Biochem J; 2017 May 30; 474(12):1993-2007. PubMed ID: 28432259
    [Abstract] [Full Text] [Related]

  • 12. Structural characterization of two metastable ATP-bound states of P-glycoprotein.
    O'Mara ML, Mark AE.
    PLoS One; 2014 May 30; 9(3):e91916. PubMed ID: 24632881
    [Abstract] [Full Text] [Related]

  • 13. ATP-dependent thermostabilization of human P-glycoprotein (ABCB1) is blocked by modulators.
    Lusvarghi S, Ambudkar SV.
    Biochem J; 2019 Dec 19; 476(24):3737-3750. PubMed ID: 31774117
    [Abstract] [Full Text] [Related]

  • 14. Interaction of the P-Glycoprotein Multidrug Transporter with Sterols.
    Clay AT, Lu P, Sharom FJ.
    Biochemistry; 2015 Nov 03; 54(43):6586-97. PubMed ID: 26484739
    [Abstract] [Full Text] [Related]

  • 15. Conformational changes in the nucleotide-binding domains of P-glycoprotein induced by ATP hydrolysis.
    Dehghani-Ghahnaviyeh S, Kapoor K, Tajkhorshid E.
    FEBS Lett; 2021 Mar 03; 595(6):735-749. PubMed ID: 33159693
    [Abstract] [Full Text] [Related]

  • 16. Substrate binding stabilizes a pre-translocation intermediate in the ATP-binding cassette transport protein MsbA.
    Doshi R, van Veen HW.
    J Biol Chem; 2013 Jul 26; 288(30):21638-47. PubMed ID: 23766512
    [Abstract] [Full Text] [Related]

  • 17. The conformational transition pathway of ATP binding cassette transporter MsbA revealed by atomistic simulations.
    Weng JW, Fan KN, Wang WN.
    J Biol Chem; 2010 Jan 29; 285(5):3053-63. PubMed ID: 19996093
    [Abstract] [Full Text] [Related]

  • 18. On the origin of large flexibility of P-glycoprotein in the inward-facing state.
    Wen PC, Verhalen B, Wilkens S, Mchaourab HS, Tajkhorshid E.
    J Biol Chem; 2013 Jun 28; 288(26):19211-20. PubMed ID: 23658020
    [Abstract] [Full Text] [Related]

  • 19. About a switch: how P-glycoprotein (ABCB1) harnesses the energy of ATP binding and hydrolysis to do mechanical work.
    Sauna ZE, Ambudkar SV.
    Mol Cancer Ther; 2007 Jan 28; 6(1):13-23. PubMed ID: 17237262
    [Abstract] [Full Text] [Related]

  • 20. ATP binding to two sites is necessary for dimerization of nucleotide-binding domains of ABC proteins.
    Zoghbi ME, Altenberg GA.
    Biochem Biophys Res Commun; 2014 Jan 03; 443(1):97-102. PubMed ID: 24269240
    [Abstract] [Full Text] [Related]

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