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922 related items for PubMed ID: 29046453

  • 1. Murine Hepatitis Virus nsp14 Exoribonuclease Activity Is Required for Resistance to Innate Immunity.
    Case JB, Li Y, Elliott R, Lu X, Graepel KW, Sexton NR, Smith EC, Weiss SR, Denison MR.
    J Virol; 2018 Jan 01; 92(1):. PubMed ID: 29046453
    [Abstract] [Full Text] [Related]

  • 2. Mutagenesis of Coronavirus nsp14 Reveals Its Potential Role in Modulation of the Innate Immune Response.
    Becares M, Pascual-Iglesias A, Nogales A, Sola I, Enjuanes L, Zuñiga S.
    J Virol; 2016 Jun 01; 90(11):5399-5414. PubMed ID: 27009949
    [Abstract] [Full Text] [Related]

  • 3. Proofreading-Deficient Coronaviruses Adapt for Increased Fitness over Long-Term Passage without Reversion of Exoribonuclease-Inactivating Mutations.
    Graepel KW, Lu X, Case JB, Sexton NR, Smith EC, Denison MR.
    mBio; 2017 Nov 07; 8(6):. PubMed ID: 29114026
    [Abstract] [Full Text] [Related]

  • 4. High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants.
    Eckerle LD, Lu X, Sperry SM, Choi L, Denison MR.
    J Virol; 2007 Nov 07; 81(22):12135-44. PubMed ID: 17804504
    [Abstract] [Full Text] [Related]

  • 5. Mutagenesis of S-Adenosyl-l-Methionine-Binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing Requirements for Genome Translation and Resistance to Innate Immunity.
    Case JB, Ashbrook AW, Dermody TS, Denison MR.
    J Virol; 2016 Aug 15; 90(16):7248-7256. PubMed ID: 27252528
    [Abstract] [Full Text] [Related]

  • 6. Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance.
    Agostini ML, Pruijssers AJ, Chappell JD, Gribble J, Lu X, Andres EL, Bluemling GR, Lockwood MA, Sheahan TP, Sims AC, Natchus MG, Saindane M, Kolykhalov AA, Painter GR, Baric RS, Denison MR.
    J Virol; 2019 Dec 15; 93(24):. PubMed ID: 31578288
    [Abstract] [Full Text] [Related]

  • 7. Mutations in coronavirus nonstructural protein 10 decrease virus replication fidelity.
    Smith EC, Case JB, Blanc H, Isakov O, Shomron N, Vignuzzi M, Denison MR.
    J Virol; 2015 Jun 15; 89(12):6418-26. PubMed ID: 25855750
    [Abstract] [Full Text] [Related]

  • 8. Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics.
    Smith EC, Blanc H, Surdel MC, Vignuzzi M, Denison MR.
    PLoS Pathog; 2013 Aug 15; 9(8):e1003565. PubMed ID: 23966862
    [Abstract] [Full Text] [Related]

  • 9. Proteolytic Processing of the Coronavirus Replicase Nonstructural Protein 14 Exonuclease Is Not Required for Virus Replication but Alters RNA Synthesis and Viral Fitness.
    Anderson-Daniels J, Gribble J, Denison M.
    J Virol; 2022 Aug 24; 96(16):e0084122. PubMed ID: 35924922
    [Abstract] [Full Text] [Related]

  • 10. The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2.
    Ogando NS, Zevenhoven-Dobbe JC, van der Meer Y, Bredenbeek PJ, Posthuma CC, Snijder EJ.
    J Virol; 2020 Nov 09; 94(23):. PubMed ID: 32938769
    [Abstract] [Full Text] [Related]

  • 11. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.
    Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, Ray AS, Cihlar T, Siegel D, Mackman RL, Clarke MO, Baric RS, Denison MR.
    mBio; 2018 Mar 06; 9(2):. PubMed ID: 29511076
    [Abstract] [Full Text] [Related]

  • 12. Porcine Epidemic Diarrhea Virus Deficient in RNA Cap Guanine-N-7 Methylation Is Attenuated and Induces Higher Type I and III Interferon Responses.
    Lu Y, Cai H, Lu M, Ma Y, Li A, Gao Y, Zhou J, Gu H, Li J, Gu J.
    J Virol; 2020 Jul 30; 94(16):. PubMed ID: 32461321
    [Abstract] [Full Text] [Related]

  • 13. N7-Methylation of the Coronavirus RNA Cap Is Required for Maximal Virulence by Preventing Innate Immune Recognition.
    Pan R, Kindler E, Cao L, Zhou Y, Zhang Z, Liu Q, Ebert N, Züst R, Sun Y, Gorbalenya AE, Perlman S, Thiel V, Chen Y, Guo D.
    mBio; 2022 Feb 22; 13(1):e0366221. PubMed ID: 35073761
    [Abstract] [Full Text] [Related]

  • 14. Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens.
    Sexton NR, Smith EC, Blanc H, Vignuzzi M, Peersen OB, Denison MR.
    J Virol; 2016 Aug 15; 90(16):7415-7428. PubMed ID: 27279608
    [Abstract] [Full Text] [Related]

  • 15. Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses.
    Athmer J, Fehr AR, Grunewald ME, Qu W, Wheeler DL, Graepel KW, Channappanavar R, Sekine A, Aldabeeb DS, Gale M, Denison MR, Perlman S.
    mBio; 2018 May 01; 9(3):. PubMed ID: 29717007
    [Abstract] [Full Text] [Related]

  • 16. The coronavirus proofreading exoribonuclease mediates extensive viral recombination.
    Gribble J, Stevens LJ, Agostini ML, Anderson-Daniels J, Chappell JD, Lu X, Pruijssers AJ, Routh AL, Denison MR.
    PLoS Pathog; 2021 Jan 01; 17(1):e1009226. PubMed ID: 33465137
    [Abstract] [Full Text] [Related]

  • 17. Coronavirus genomic nsp14-ExoN, structure, role, mechanism, and potential application as a drug target.
    Tahir M.
    J Med Virol; 2021 Jul 01; 93(7):4258-4264. PubMed ID: 33837972
    [Abstract] [Full Text] [Related]

  • 18. Fitness Barriers Limit Reversion of a Proofreading-Deficient Coronavirus.
    Graepel KW, Agostini ML, Lu X, Sexton NR, Denison MR.
    J Virol; 2019 Oct 15; 93(20):. PubMed ID: 31341046
    [Abstract] [Full Text] [Related]

  • 19. Antagonism of dsRNA-Induced Innate Immune Pathways by NS4a and NS4b Accessory Proteins during MERS Coronavirus Infection.
    Comar CE, Goldstein SA, Li Y, Yount B, Baric RS, Weiss SR.
    mBio; 2019 Mar 26; 10(2):. PubMed ID: 30914508
    [Abstract] [Full Text] [Related]

  • 20. Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN.
    Moeller NH, Shi K, Demir Ö, Belica C, Banerjee S, Yin L, Durfee C, Amaro RE, Aihara H.
    Proc Natl Acad Sci U S A; 2022 Mar 01; 119(9):. PubMed ID: 35165203
    [Abstract] [Full Text] [Related]

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