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219 related items for PubMed ID: 29121398

  • 1. Protein phosphatase 2A and tau: an orchestrated 'Pas de Deux'.
    Taleski G, Sontag E.
    FEBS Lett; 2018 Apr; 592(7):1079-1095. PubMed ID: 29121398
    [Abstract] [Full Text] [Related]

  • 2. The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies.
    Sontag JM, Nunbhakdi-Craig V, White CL, Halpain S, Sontag E.
    J Biol Chem; 2012 Apr 27; 287(18):14984-93. PubMed ID: 22403409
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  • 5. Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.
    Louis JV, Martens E, Borghgraef P, Lambrecht C, Sents W, Longin S, Zwaenepoel K, Pijnenborg R, Landrieu I, Lippens G, Ledermann B, Götz J, Van Leuven F, Goris J, Janssens V.
    Proc Natl Acad Sci U S A; 2011 Apr 26; 108(17):6957-62. PubMed ID: 21482799
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  • 6. Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells.
    Sontag JM, Nunbhakdi-Craig V, Sontag E.
    J Biol Chem; 2013 Sep 20; 288(38):27396-27405. PubMed ID: 23943618
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  • 7. Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation.
    Xu Y, Chen Y, Zhang P, Jeffrey PD, Shi Y.
    Mol Cell; 2008 Sep 26; 31(6):873-85. PubMed ID: 18922469
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  • 8. Cornel Iridoid Glycoside Suppresses Tau Hyperphosphorylation and Aggregation in a Mouse Model of Tauopathy through Increasing Activity of PP2A.
    Ma D, Luo Y, Huang R, Zhao Z, Wang Q, Li L, Zhang L.
    Curr Alzheimer Res; 2019 Sep 26; 16(14):1316-1331. PubMed ID: 31902362
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  • 9. Tau phosphorylation and aggregation as a therapeutic target in tauopathies.
    Badiola N, Suárez-Calvet M, Lleó A.
    CNS Neurol Disord Drug Targets; 2010 Dec 26; 9(6):727-40. PubMed ID: 20942789
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  • 10. Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling.
    Kickstein E, Krauss S, Thornhill P, Rutschow D, Zeller R, Sharkey J, Williamson R, Fuchs M, Köhler A, Glossmann H, Schneider R, Sutherland C, Schweiger S.
    Proc Natl Acad Sci U S A; 2010 Dec 14; 107(50):21830-5. PubMed ID: 21098287
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  • 11. Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation.
    Xiong Y, Jing XP, Zhou XW, Wang XL, Yang Y, Sun XY, Qiu M, Cao FY, Lu YM, Liu R, Wang JZ.
    Neurobiol Aging; 2013 Mar 14; 34(3):745-56. PubMed ID: 22892311
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  • 12. Tau pathology in Alzheimer disease and other tauopathies.
    Iqbal K, Alonso Adel C, Chen S, Chohan MO, El-Akkad E, Gong CX, Khatoon S, Li B, Liu F, Rahman A, Tanimukai H, Grundke-Iqbal I.
    Biochim Biophys Acta; 2005 Jan 03; 1739(2-3):198-210. PubMed ID: 15615638
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  • 13. Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation.
    Sontag JM, Nunbhakdi-Craig V, Montgomery L, Arning E, Bottiglieri T, Sontag E.
    J Neurosci; 2008 Nov 05; 28(45):11477-87. PubMed ID: 18987184
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  • 14. PP2A subunit PPP2R2C is downregulated in the brains of Alzheimer's transgenic mice.
    Leong W, Xu W, Wang B, Gao S, Zhai X, Wang C, Gilson E, Ye J, Lu Y.
    Aging (Albany NY); 2020 Apr 14; 12(8):6880-6890. PubMed ID: 32291379
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  • 15. Early glycogen synthase kinase-3β and protein phosphatase 2A independent tau dephosphorylation during global brain ischaemia and reperfusion following cardiac arrest and the role of the adenosine monophosphate kinase pathway.
    Majd S, Power JH, Koblar SA, Grantham HJ.
    Eur J Neurosci; 2016 Aug 14; 44(3):1987-97. PubMed ID: 27177932
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  • 16. A mathematical model of multisite phosphorylation of tau protein.
    Stepanov A, Karelina T, Markevich N, Demin O, Nicholas T.
    PLoS One; 2018 Aug 14; 13(2):e0192519. PubMed ID: 29408874
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  • 17. Role of microtubule-associated protein tau phosphorylation in Alzheimer's disease.
    Ma RH, Zhang Y, Hong XY, Zhang JF, Wang JZ, Liu GP.
    J Huazhong Univ Sci Technolog Med Sci; 2017 Jun 14; 37(3):307-312. PubMed ID: 28585125
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  • 18. Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies.
    Sontag E, Nunbhakdi-Craig V, Lee G, Brandt R, Kamibayashi C, Kuret J, White CL, Mumby MC, Bloom GS.
    J Biol Chem; 1999 Sep 03; 274(36):25490-8. PubMed ID: 10464280
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  • 19. Tau and tauopathies.
    Arendt T, Stieler JT, Holzer M.
    Brain Res Bull; 2016 Sep 03; 126(Pt 3):238-292. PubMed ID: 27615390
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