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719 related items for PubMed ID: 29188556

  • 1. Current and Future Challenges in GPCR Drug Discovery.
    Topiol S.
    Methods Mol Biol; 2018; 1705():1-21. PubMed ID: 29188556
    [Abstract] [Full Text] [Related]

  • 2. Bitopic Ligands and Metastable Binding Sites: Opportunities for G Protein-Coupled Receptor (GPCR) Medicinal Chemistry.
    Fronik P, Gaiser BI, Sejer Pedersen D.
    J Med Chem; 2017 May 25; 60(10):4126-4134. PubMed ID: 28140580
    [Abstract] [Full Text] [Related]

  • 3. Computational Advances for the Development of Allosteric Modulators and Bitopic Ligands in G Protein-Coupled Receptors.
    Feng Z, Hu G, Ma S, Xie XQ.
    AAPS J; 2015 Sep 25; 17(5):1080-95. PubMed ID: 25940084
    [Abstract] [Full Text] [Related]

  • 4. Opportunities and Challenges in the Discovery of Allosteric Modulators of GPCRs.
    Bartuzi D, Kaczor AA, Matosiuk D.
    Methods Mol Biol; 2018 Sep 25; 1705():297-319. PubMed ID: 29188568
    [Abstract] [Full Text] [Related]

  • 5. Strategies for the identification of allosteric modulators of G-protein-coupled receptors.
    Burford NT, Watson J, Bertekap R, Alt A.
    Biochem Pharmacol; 2011 Mar 15; 81(6):691-702. PubMed ID: 21184747
    [Abstract] [Full Text] [Related]

  • 6. Advances in G protein-coupled receptor allostery: from function to structure.
    Christopoulos A.
    Mol Pharmacol; 2014 Nov 15; 86(5):463-78. PubMed ID: 25061106
    [Abstract] [Full Text] [Related]

  • 7. Orthosteric/allosteric bitopic ligands: going hybrid at GPCRs.
    Valant C, Sexton PM, Christopoulos A.
    Mol Interv; 2009 Jun 15; 9(3):125-35. PubMed ID: 19592673
    [Abstract] [Full Text] [Related]

  • 8. Leveraging allostery to improve G protein-coupled receptor (GPCR)-directed therapeutics: cannabinoid receptor 1 as discovery target.
    Janero DR, Thakur GA.
    Expert Opin Drug Discov; 2016 Dec 15; 11(12):1223-1237. PubMed ID: 27712124
    [Abstract] [Full Text] [Related]

  • 9. G protein-coupled receptors (GPCRs): advances in structures, mechanisms, and drug discovery.
    Zhang M, Chen T, Lu X, Lan X, Chen Z, Lu S.
    Signal Transduct Target Ther; 2024 Apr 10; 9(1):88. PubMed ID: 38594257
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  • 10. Novel Allosteric Modulators of G Protein-coupled Receptors.
    Gentry PR, Sexton PM, Christopoulos A.
    J Biol Chem; 2015 Aug 07; 290(32):19478-88. PubMed ID: 26100627
    [Abstract] [Full Text] [Related]

  • 11. Allosteric Modulators of the Class A G Protein Coupled Receptors.
    Tschammer N.
    Adv Exp Med Biol; 2016 Aug 07; 917():185-207. PubMed ID: 27236557
    [Abstract] [Full Text] [Related]

  • 12. Molecular alliance-from orthosteric and allosteric ligands to dualsteric/bitopic agonists at G protein coupled receptors.
    Mohr K, Schmitz J, Schrage R, Tränkle C, Holzgrabe U.
    Angew Chem Int Ed Engl; 2013 Jan 07; 52(2):508-16. PubMed ID: 23225228
    [Abstract] [Full Text] [Related]

  • 13. Allosteric modulation of GPCRs: From structural insights to in silico drug discovery.
    Persechino M, Hedderich JB, Kolb P, Hilger D.
    Pharmacol Ther; 2022 Sep 07; 237():108242. PubMed ID: 35863587
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  • 14. Pharmacology of Free Fatty Acid Receptors and Their Allosteric Modulators.
    Grundmann M, Bender E, Schamberger J, Eitner F.
    Int J Mol Sci; 2021 Feb 10; 22(4):. PubMed ID: 33578942
    [Abstract] [Full Text] [Related]

  • 15. GPCR crystal structures: Medicinal chemistry in the pocket.
    Shonberg J, Kling RC, Gmeiner P, Löber S.
    Bioorg Med Chem; 2015 Jul 15; 23(14):3880-906. PubMed ID: 25638496
    [Abstract] [Full Text] [Related]

  • 16. Allosteric modulation of G protein-coupled receptors: a pharmacological perspective.
    Keov P, Sexton PM, Christopoulos A.
    Neuropharmacology; 2011 Jan 15; 60(1):24-35. PubMed ID: 20637785
    [Abstract] [Full Text] [Related]

  • 17. GPCR Allosteric Modulator Discovery.
    Wu Y, Tong J, Ding K, Zhou Q, Zhao S.
    Adv Exp Med Biol; 2019 Jan 15; 1163():225-251. PubMed ID: 31707706
    [Abstract] [Full Text] [Related]

  • 18. Small Molecule Allosteric Modulators of G-Protein-Coupled Receptors: Drug-Target Interactions.
    Lu S, Zhang J.
    J Med Chem; 2019 Jan 10; 62(1):24-45. PubMed ID: 29457894
    [Abstract] [Full Text] [Related]

  • 19. Allosteric inhibition of g-protein coupled receptor oligomerization: strategies and challenges for drug development.
    Hurevich M, Talhami A, Shalev DE, Gilon C.
    Curr Top Med Chem; 2014 Jan 10; 14(15):1842-63. PubMed ID: 25175995
    [Abstract] [Full Text] [Related]

  • 20. Bridging the gap: bitopic ligands of G-protein-coupled receptors.
    Lane JR, Sexton PM, Christopoulos A.
    Trends Pharmacol Sci; 2013 Jan 10; 34(1):59-66. PubMed ID: 23177916
    [Abstract] [Full Text] [Related]

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