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146 related items for PubMed ID: 29223348

  • 1. Distinctive binding properties of the negative allosteric modulator, [3H]SB269,652, at recombinant dopamine D3 receptors.
    Fasciani I, Pietrantoni I, Rossi M, Mannoury la Cour C, Aloisi G, Marampon F, Scarselli M, Millan MJ, Maggio R.
    Eur J Pharmacol; 2018 Jan 15; 819():181-189. PubMed ID: 29223348
    [Abstract] [Full Text] [Related]

  • 2. The tetrahydroisoquinoline derivative SB269,652 is an allosteric antagonist at dopamine D3 and D2 receptors.
    Silvano E, Millan MJ, Mannoury la Cour C, Han Y, Duan L, Griffin SA, Luedtke RR, Aloisi G, Rossi M, Zazzeroni F, Javitch JA, Maggio R.
    Mol Pharmacol; 2010 Nov 15; 78(5):925-34. PubMed ID: 20702763
    [Abstract] [Full Text] [Related]

  • 3. The First Negative Allosteric Modulator for Dopamine D2 and D3 Receptors, SB269652 May Lead to a New Generation of Antipsychotic Drugs.
    Rossi M, Fasciani I, Marampon F, Maggio R, Scarselli M.
    Mol Pharmacol; 2017 Jun 15; 91(6):586-594. PubMed ID: 28265019
    [Abstract] [Full Text] [Related]

  • 4. Dopamine D2 Receptors Dimers: How can we Pharmacologically Target Them?
    Carli M, Kolachalam S, Aringhieri S, Rossi M, Giovannini L, Maggio R, Scarselli M.
    Curr Neuropharmacol; 2018 Jan 30; 16(2):222-230. PubMed ID: 28521704
    [Abstract] [Full Text] [Related]

  • 5. Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand.
    Mistry SN, Shonberg J, Draper-Joyce CJ, Klein Herenbrink C, Michino M, Shi L, Christopoulos A, Capuano B, Scammells PJ, Lane JR.
    J Med Chem; 2015 Sep 10; 58(17):6819-43. PubMed ID: 26258690
    [Abstract] [Full Text] [Related]

  • 6. [3H]S33084: a novel, selective and potent radioligand at cloned, human dopamine D3 receptors.
    Cussac D, Newman-Tancredi A, Sezgin L, Millan MJ.
    Naunyn Schmiedebergs Arch Pharmacol; 2000 May 10; 361(5):569-72. PubMed ID: 10832613
    [Abstract] [Full Text] [Related]

  • 7. Structure-activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor.
    Shonberg J, Draper-Joyce C, Mistry SN, Christopoulos A, Scammells PJ, Lane JR, Capuano B.
    J Med Chem; 2015 Jul 09; 58(13):5287-307. PubMed ID: 26052807
    [Abstract] [Full Text] [Related]

  • 8. In Vitro and In Vivo Identification of Novel Positive Allosteric Modulators of the Human Dopamine D2 and D3 Receptor.
    Wood M, Ates A, Andre VM, Michel A, Barnaby R, Gillard M.
    Mol Pharmacol; 2016 Feb 09; 89(2):303-12. PubMed ID: 26655303
    [Abstract] [Full Text] [Related]

  • 9. Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor.
    Grundt P, Carlson EE, Cao J, Bennett CJ, McElveen E, Taylor M, Luedtke RR, Newman AH.
    J Med Chem; 2005 Feb 10; 48(3):839-48. PubMed ID: 15689168
    [Abstract] [Full Text] [Related]

  • 10. S33138 [N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1]-benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenylacetamide], a preferential dopamine D3 versus D2 receptor antagonist and potential antipsychotic agent: I. Receptor-binding profile and functional actions at G-protein-coupled receptors.
    Millan MJ, Mannoury la Cour C, Novi F, Maggio R, Audinot V, Newman-Tancredi A, Cussac D, Pasteau V, Boutin JA, Dubuffet T, Lavielle G.
    J Pharmacol Exp Ther; 2008 Feb 10; 324(2):587-99. PubMed ID: 18024789
    [Abstract] [Full Text] [Related]

  • 11. Dysbindin-1 modifies signaling and cellular localization of recombinant, human D₃ and D₂ receptors.
    Schmieg N, Rocchi C, Romeo S, Maggio R, Millan MJ, Mannoury la Cour C.
    J Neurochem; 2016 Mar 10; 136(5):1037-51. PubMed ID: 26685100
    [Abstract] [Full Text] [Related]

  • 12. Comparison of the functional potencies of ropinirole and other dopamine receptor agonists at human D2(long), D3 and D4.4 receptors expressed in Chinese hamster ovary cells.
    Coldwell MC, Boyfield I, Brown T, Hagan JJ, Middlemiss DN.
    Br J Pharmacol; 1999 Aug 10; 127(7):1696-702. PubMed ID: 10455328
    [Abstract] [Full Text] [Related]

  • 13. The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions.
    Draper-Joyce CJ, Verma RK, Michino M, Shonberg J, Kopinathan A, Klein Herenbrink C, Scammells PJ, Capuano B, Abramyan AM, Thal DM, Javitch JA, Christopoulos A, Shi L, Lane JR.
    Sci Rep; 2018 Jan 19; 8(1):1208. PubMed ID: 29352161
    [Abstract] [Full Text] [Related]

  • 14. Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents.
    Sautel F, Griffon N, Sokoloff P, Schwartz JC, Launay C, Simon P, Costentin J, Schoenfelder A, Garrido F, Mann A.
    J Pharmacol Exp Ther; 1995 Dec 19; 275(3):1239-46. PubMed ID: 8531087
    [Abstract] [Full Text] [Related]

  • 15. D2 dopamine receptors and modulation of spontaneous acetylcholine (ACh) release from rat striatal synaptosomes.
    Clos MV, García-Sanz A, Vivas NM, Badia A.
    Br J Pharmacol; 1997 Sep 19; 122(2):286-90. PubMed ID: 9313937
    [Abstract] [Full Text] [Related]

  • 16. Potent activation of dopamine D3/D2 heterodimers by the antiparkinsonian agents, S32504, pramipexole and ropinirole.
    Maggio R, Scarselli M, Novi F, Millan MJ, Corsini GU.
    J Neurochem; 2003 Nov 19; 87(3):631-41. PubMed ID: 14535946
    [Abstract] [Full Text] [Related]

  • 17. Evidence for Two Modes of Binding of the Negative Allosteric Modulator SB269,652 to the Dopamine D2 Receptor.
    Ågren R, Sahlholm K.
    Biomedicines; 2021 Dec 23; 10(1):. PubMed ID: 35052702
    [Abstract] [Full Text] [Related]

  • 18. Cariprazine (RGH-188), a dopamine D(3) receptor-preferring, D(3)/D(2) dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile.
    Kiss B, Horváth A, Némethy Z, Schmidt E, Laszlovszky I, Bugovics G, Fazekas K, Hornok K, Orosz S, Gyertyán I, Agai-Csongor E, Domány G, Tihanyi K, Adham N, Szombathelyi Z.
    J Pharmacol Exp Ther; 2010 Apr 23; 333(1):328-40. PubMed ID: 20093397
    [Abstract] [Full Text] [Related]

  • 19. The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor.
    Draper-Joyce CJ, Michino M, Verma RK, Klein Herenbrink C, Shonberg J, Kopinathan A, Scammells PJ, Capuano B, Thal DM, Javitch JA, Christopoulos A, Shi L, Lane JR.
    Biochem Pharmacol; 2018 Feb 23; 148():315-328. PubMed ID: 29325769
    [Abstract] [Full Text] [Related]

  • 20. Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R).
    Kumar V, Moritz AE, Keck TM, Bonifazi A, Ellenberger MP, Sibley CD, Free RB, Shi L, Lane JR, Sibley DR, Newman AH.
    J Med Chem; 2017 Feb 23; 60(4):1478-1494. PubMed ID: 28186762
    [Abstract] [Full Text] [Related]

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