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160 related items for PubMed ID: 2930626

  • 1. Quinazoline antifolates inhibiting thymidylate synthase: computer modelling of the N10 substituent.
    Jones TR, Betteridge RF, Neidle S, Jackman AL, Calvert AH.
    Anticancer Drug Des; 1989 Mar; 3(4):243-8. PubMed ID: 2930626
    [Abstract] [Full Text] [Related]

  • 2. Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies.
    Jackman AL, Alison DL, Calvert AH, Harrap KR.
    Cancer Res; 1986 Jun; 46(6):2810-5. PubMed ID: 2938731
    [Abstract] [Full Text] [Related]

  • 3. Quinazoline antifolates inhibiting thymidylate synthase: variation of the N10 substituent.
    Jones TR, Calvert AH, Jackman AL, Eakin MA, Smithers MJ, Betteridge RF, Newell DR, Hayter AJ, Stocker A, Harland SJ.
    J Med Chem; 1985 Oct; 28(10):1468-76. PubMed ID: 4045922
    [Abstract] [Full Text] [Related]

  • 4. Quinazoline antifolates inhibiting thymidylate synthase: 4-thio-substituted analogues.
    Thornton TJ, Jones TR, Jackman AL, Flinn A, O'Connor BM, Warner P, Calvert AH.
    J Med Chem; 1991 Mar; 34(3):978-84. PubMed ID: 2002476
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  • 7. Quinazoline antifolate thymidylate synthase inhibitors: nitrogen, oxygen, sulfur, and chlorine substituents in the C2 position.
    Marsham PR, Chambers P, Hayter AJ, Hughes LR, Jackman AL, O'Connor BM, Bishop JA, Calvert AH.
    J Med Chem; 1989 Mar; 32(3):569-75. PubMed ID: 2918503
    [Abstract] [Full Text] [Related]

  • 8. Activity of the thymidylate synthase inhibitor 2-desamino-N10-propargyl-5,8-dideazafolic acid and related compounds in murine (L1210) and human (W1L2) systems in vitro and in L1210 in vivo.
    Jackman AL, Taylor GA, O'Connor BM, Bishop JA, Moran RG, Calvert AH.
    Cancer Res; 1990 Sep 01; 50(17):5212-8. PubMed ID: 2386929
    [Abstract] [Full Text] [Related]

  • 9. Quinazoline antifolates inhibiting thymidylate synthase: synthesis of gamma-linked peptide and amide analogues of 2-desamino-2-methyl-N10-propargyl- 5,8-dideazafolic acid (ICI 198583).
    Bavetsias V, Jackman AL, Thornton TJ, Pawelczak K, Boyle FT, Bisset GM.
    Adv Exp Med Biol; 1993 Sep 01; 338():593-6. PubMed ID: 8304188
    [No Abstract] [Full Text] [Related]

  • 10. Quinazoline antifolates inhibiting thymidylate synthase: benzoyl ring modifications.
    Jones TR, Smithers MJ, Taylor MA, Jackman AL, Calvert AH, Harland SJ, Harrap KR.
    J Med Chem; 1986 Apr 01; 29(4):468-72. PubMed ID: 3754284
    [Abstract] [Full Text] [Related]

  • 11. Quinazoline antifolates thymidylate synthase inhibitors: lipophilic analogues with modification to the C2-methyl substituent.
    Hennequin LF, Boyle FT, Wardleworth JM, Marsham PR, Kimbell R, Jackman AL.
    J Med Chem; 1996 Feb 02; 39(3):695-704. PubMed ID: 8576912
    [Abstract] [Full Text] [Related]

  • 12. Quinazoline antifolates inhibiting thymidylate synthase: variation of the amino acid.
    Jones TR, Smithers MJ, Betteridge RF, Taylor MA, Jackman AL, Calvert AH, Davies LC, Harrap KR.
    J Med Chem; 1986 Jun 02; 29(6):1114-8. PubMed ID: 3712376
    [Abstract] [Full Text] [Related]

  • 13. Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
    Westerhof GR, Schornagel JH, Kathmann I, Jackman AL, Rosowsky A, Forsch RA, Hynes JB, Boyle FT, Peters GJ, Pinedo HM.
    Mol Pharmacol; 1995 Sep 02; 48(3):459-71. PubMed ID: 7565626
    [Abstract] [Full Text] [Related]

  • 14. Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF).
    Nair MG, Nanavati NT, Nair IG, Kisliuk RL, Gaumont Y, Hsiao MC, Kalman TI.
    J Med Chem; 1986 Sep 02; 29(9):1754-60. PubMed ID: 3091832
    [Abstract] [Full Text] [Related]

  • 15. Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds.
    Nair MG, Dhawan R, Ghazala M, Kalman TI, Ferone R, Gaumont Y, Kisliuk RL.
    J Med Chem; 1987 Jul 02; 30(7):1256-61. PubMed ID: 3599032
    [Abstract] [Full Text] [Related]

  • 16. Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position.
    Jackman AL, Marsham PR, Thornton TJ, Bishop JA, O'Connor BM, Hughes LR, Calvert AH, Jones TR.
    J Med Chem; 1990 Nov 02; 33(11):3067-71. PubMed ID: 2231607
    [Abstract] [Full Text] [Related]

  • 17. Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potency.
    Jones TR, Thornton TJ, Flinn A, Jackman AL, Newell DR, Calvert AH.
    J Med Chem; 1989 Apr 02; 32(4):847-52. PubMed ID: 2704030
    [Abstract] [Full Text] [Related]

  • 18. Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues.
    Thornton TJ, Jackman AL, Marsham PR, O'Connor BM, Bishop JA, Calvert AH.
    J Med Chem; 1992 Jun 12; 35(12):2321-7. PubMed ID: 1613755
    [Abstract] [Full Text] [Related]

  • 19. Folate-based inhibitors of thymidylate synthase: synthesis and antitumor activity of gamma-linked sterically hindered dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
    Bavetsias V, Jackman AL, Marriott JH, Kimbell R, Gibson W, Boyle FT, Bisset GM.
    J Med Chem; 1997 May 09; 40(10):1495-510. PubMed ID: 9154971
    [Abstract] [Full Text] [Related]

  • 20. Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines.
    McNamara DJ, Berman EM, Fry DW, Werbel LM.
    J Med Chem; 1990 Jul 09; 33(7):2045-51. PubMed ID: 2362285
    [Abstract] [Full Text] [Related]

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