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457 related items for PubMed ID: 29335553

  • 1. Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis.
    Ates LS, Dippenaar A, Ummels R, Piersma SR, van der Woude AD, van der Kuij K, Le Chevalier F, Mata-Espinosa D, Barrios-Payán J, Marquina-Castillo B, Guapillo C, Jiménez CR, Pain A, Houben ENG, Warren RM, Brosch R, Hernández-Pando R, Bitter W.
    Nat Microbiol; 2018 Feb; 3(2):181-188. PubMed ID: 29335553
    [Abstract] [Full Text] [Related]

  • 2. RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection.
    Ates LS, Sayes F, Frigui W, Ummels R, Damen MPM, Bottai D, Behr MA, van Heijst JWJ, Bitter W, Majlessi L, Brosch R.
    PLoS Pathog; 2018 Jun; 14(6):e1007139. PubMed ID: 29912964
    [Abstract] [Full Text] [Related]

  • 3. PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX-5.
    Abdallah AM, Verboom T, Weerdenburg EM, Gey van Pittius NC, Mahasha PW, Jiménez C, Parra M, Cadieux N, Brennan MJ, Appelmelk BJ, Bitter W.
    Mol Microbiol; 2009 Aug; 73(3):329-40. PubMed ID: 19602152
    [Abstract] [Full Text] [Related]

  • 4. ESX/type VII secretion systems of mycobacteria: Insights into evolution, pathogenicity and protection.
    Simeone R, Bottai D, Frigui W, Majlessi L, Brosch R.
    Tuberculosis (Edinb); 2015 Jun; 95 Suppl 1():S150-4. PubMed ID: 25732627
    [Abstract] [Full Text] [Related]

  • 5. Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.
    Bottai D, Di Luca M, Majlessi L, Frigui W, Simeone R, Sayes F, Bitter W, Brennan MJ, Leclerc C, Batoni G, Campa M, Brosch R, Esin S.
    Mol Microbiol; 2012 Mar; 83(6):1195-209. PubMed ID: 22340629
    [Abstract] [Full Text] [Related]

  • 6. Evidence for a rapid rate of molecular evolution at the hypervariable and immunogenic Mycobacterium tuberculosis PPE38 gene region.
    McEvoy CR, van Helden PD, Warren RM, Gey van Pittius NC.
    BMC Evol Biol; 2009 Sep 21; 9():237. PubMed ID: 19769792
    [Abstract] [Full Text] [Related]

  • 7. Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence.
    Tufariello JM, Chapman JR, Kerantzas CA, Wong KW, Vilchèze C, Jones CM, Cole LE, Tinaztepe E, Thompson V, Fenyö D, Niederweis M, Ueberheide B, Philips JA, Jacobs WR.
    Proc Natl Acad Sci U S A; 2016 Jan 19; 113(3):E348-57. PubMed ID: 26729876
    [Abstract] [Full Text] [Related]

  • 8. Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions.
    Gey van Pittius NC, Sampson SL, Lee H, Kim Y, van Helden PD, Warren RM.
    BMC Evol Biol; 2006 Nov 15; 6():95. PubMed ID: 17105670
    [Abstract] [Full Text] [Related]

  • 9. Modular Organization of the ESX-5 Secretion System in Mycobacterium tuberculosis.
    Shah S, Briken V.
    Front Cell Infect Microbiol; 2016 Nov 15; 6():49. PubMed ID: 27200304
    [Abstract] [Full Text] [Related]

  • 10. A Duplicated ESAT-6 Region of ESX-5 Is Involved in Protein Export and Virulence of Mycobacteria.
    Shah S, Cannon JR, Fenselau C, Briken V.
    Infect Immun; 2015 Nov 15; 83(11):4349-61. PubMed ID: 26303392
    [Abstract] [Full Text] [Related]

  • 11. Type VII Secretion Substrates of Pathogenic Mycobacteria Are Processed by a Surface Protease.
    Burggraaf MJ, Speer A, Meijers AS, Ummels R, van der Sar AM, Korotkov KV, Bitter W, Kuijl C.
    mBio; 2019 Oct 29; 10(5):. PubMed ID: 31662454
    [Abstract] [Full Text] [Related]

  • 12. PPE38-Secretion-Dependent Proteins of M. tuberculosis Alter NF-kB Signalling and Inflammatory Responses in Macrophages.
    Gallant J, Heunis T, Beltran C, Schildermans K, Bruijns S, Mertens I, Bitter W, Sampson SL.
    Front Immunol; 2021 Oct 29; 12():702359. PubMed ID: 34276695
    [Abstract] [Full Text] [Related]

  • 13. Species-specific secretion of ESX-5 type VII substrates is determined by the linker 2 of EccC5.
    Bunduc CM, Ummels R, Bitter W, Houben ENG.
    Mol Microbiol; 2020 Jul 29; 114(1):66-76. PubMed ID: 32096294
    [Abstract] [Full Text] [Related]

  • 14. An overview to understand the role of PE_PGRS family proteins in Mycobacterium tuberculosis H37 Rv and their potential as new drug targets.
    Meena LS.
    Biotechnol Appl Biochem; 2015 Jul 29; 62(2):145-53. PubMed ID: 24975480
    [Abstract] [Full Text] [Related]

  • 15. Mycobacterium tuberculosis Toxin CpnT Is an ESX-5 Substrate and Requires Three Type VII Secretion Systems for Intracellular Secretion.
    Izquierdo Lafuente B, Ummels R, Kuijl C, Bitter W, Speer A.
    mBio; 2021 Mar 02; 12(2):. PubMed ID: 33653883
    [Abstract] [Full Text] [Related]

  • 16. The ESX-1 Substrate PPE68 Has a Key Function in ESX-1-Mediated Secretion in Mycobacterium marinum.
    Damen MPM, Meijers AS, Keizer EM, Piersma SR, Jiménez CR, Kuijl CP, Bitter W, Houben ENG.
    mBio; 2022 Dec 20; 13(6):e0281922. PubMed ID: 36409073
    [Abstract] [Full Text] [Related]

  • 17. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis.
    Champion PA, Stanley SA, Champion MM, Brown EJ, Cox JS.
    Science; 2006 Sep 15; 313(5793):1632-6. PubMed ID: 16973880
    [Abstract] [Full Text] [Related]

  • 18. Mycobacterium tuberculosis Requires Regulation of ESX-5 Secretion for Virulence in Irgm1-Deficient Mice.
    Elliott SR, White DW, Tischler AD.
    Infect Immun; 2019 Feb 15; 87(2):. PubMed ID: 30455198
    [Abstract] [Full Text] [Related]

  • 19. A metabolomics investigation of the function of the ESX-1 gene cluster in mycobacteria.
    Loots DT, Swanepoel CC, Newton-Foot M, Gey van Pittius NC.
    Microb Pathog; 2016 Nov 15; 100():268-275. PubMed ID: 27744102
    [Abstract] [Full Text] [Related]

  • 20. Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion: encoded PE-PPE proteins predicts vaccine potential.
    Sayes F, Sun L, Di Luca M, Simeone R, Degaiffier N, Fiette L, Esin S, Brosch R, Bottai D, Leclerc C, Majlessi L.
    Cell Host Microbe; 2012 Apr 19; 11(4):352-63. PubMed ID: 22520463
    [Abstract] [Full Text] [Related]

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