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Journal Abstract Search

90 related items for PubMed ID: 29339398

  • 1. Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-Facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake.
    Gorboulev V, Rehman S, Albert CM, Roth U, Meyer MJ, Tzvetkov MV, Mueller TD, Koepsell H.
    Mol Pharmacol; 2018 Apr; 93(4):402-415. PubMed ID: 29339398
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  • 2. Five amino acids in the innermost cavity of the substrate binding cleft of organic cation transporter 1 interact with extracellular and intracellular corticosterone.
    Volk C, Gorboulev V, Kotzsch A, Müller TD, Koepsell H.
    Mol Pharmacol; 2009 Aug; 76(2):275-89. PubMed ID: 19435783
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  • 3. Subtype-specific affinity for corticosterone of rat organic cation transporters rOCT1 and rOCT2 depends on three amino acids within the substrate binding region.
    Gorboulev V, Shatskaya N, Volk C, Koepsell H.
    Mol Pharmacol; 2005 May; 67(5):1612-9. PubMed ID: 15662045
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  • 4. Purification and functional reconstitution of the rat organic cation transporter OCT1.
    Keller T, Elfeber M, Gorboulev V, Reiländer H, Koepsell H.
    Biochemistry; 2005 Sep 13; 44(36):12253-63. PubMed ID: 16142924
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  • 5. High-affinity cation binding to organic cation transporter 1 induces movement of helix 11 and blocks transport after mutations in a modeled interaction domain between two helices.
    Gorbunov D, Gorboulev V, Shatskaya N, Mueller T, Bamberg E, Friedrich T, Koepsell H.
    Mol Pharmacol; 2008 Jan 13; 73(1):50-61. PubMed ID: 17940192
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  • 8. Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer.
    Keller T, Gorboulev V, Mueller TD, Dötsch V, Bernhard F, Koepsell H.
    Mol Pharmacol; 2019 Feb 13; 95(2):169-182. PubMed ID: 30409791
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  • 9. Substrate- and cell contact-dependent inhibitor affinity of human organic cation transporter 2: studies with two classical organic cation substrates and the novel substrate cd2+.
    Thévenod F, Ciarimboli G, Leistner M, Wolff NA, Lee WK, Schatz I, Keller T, Al-Monajjed R, Gorboulev V, Koepsell H.
    Mol Pharm; 2013 Aug 05; 10(8):3045-56. PubMed ID: 23763587
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  • 12. Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates.
    Umehara KI, Iwatsubo T, Noguchi K, Kamimura H.
    Xenobiotica; 2007 Jun 05; 37(6):618-34. PubMed ID: 17614008
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  • 13. Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity.
    Sturm A, Gorboulev V, Gorbunov D, Keller T, Volk C, Schmitt BM, Schlachtbauer P, Ciarimboli G, Koepsell H.
    Am J Physiol Renal Physiol; 2007 Sep 05; 293(3):F767-79. PubMed ID: 17567940
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  • 14. Charge-to-substrate ratio during organic cation uptake by rat OCT2 is voltage dependent and altered by exchange of glutamate 448 with glutamine.
    Schmitt BM, Gorbunov D, Schlachtbauer P, Egenberger B, Gorboulev V, Wischmeyer E, Müller T, Koepsell H.
    Am J Physiol Renal Physiol; 2009 Apr 05; 296(4):F709-22. PubMed ID: 19211691
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  • 15. Different affinities of inhibitors to the outwardly and inwardly directed substrate binding site of organic cation transporter 2.
    Volk C, Gorboulev V, Budiman T, Nagel G, Koepsell H.
    Mol Pharmacol; 2003 Nov 05; 64(5):1037-47. PubMed ID: 14573752
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  • 16. Substrate-dependent ligand inhibition of the human organic cation transporter OCT2.
    Belzer M, Morales M, Jagadish B, Mash EA, Wright SH.
    J Pharmacol Exp Ther; 2013 Aug 05; 346(2):300-10. PubMed ID: 23709117
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  • 20. Nitric oxide-induced regulation of renal organic cation transport after renal ischemia-reperfusion injury.
    Schneider R, Meusel M, Betz B, Kersten M, Möller-Ehrlich K, Wanner C, Koepsell H, Sauvant C.
    Am J Physiol Renal Physiol; 2011 Nov 05; 301(5):F997-F1004. PubMed ID: 21835768
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