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Journal Abstract Search

126 related items for PubMed ID: 29374184

  • 1. Creating a mouse model resistant to induced ischemic stroke and cardiovascular damage.
    Ling QL, Mohite AJ, Murdoch E, Akasaka H, Li QY, So SP, Ruan KH.
    Sci Rep; 2018 Jan 26; 8(1):1653. PubMed ID: 29374184
    [Abstract] [Full Text] [Related]

  • 2. Prostacyclin Synthase Deficiency Leads to Exacerbation or Occurrence of Endothelium-Dependent Contraction and Causes Cardiovascular Disorders Mainly via the Non-TxA2 Prostanoids/TP Axis.
    Ge J, Zhou Y, Li H, Zeng R, Xie K, Leng J, Chen X, Yu G, Shi X, Xu Y, He D, Guo P, Zhou Y, Luo H, Luo W, Liu B.
    Circ Res; 2024 Aug 30; 135(6):e133-e149. PubMed ID: 39082135
    [Abstract] [Full Text] [Related]

  • 3. Relationship of the Topological Distances and Activities between mPGES-1 and COX-2 versus COX-1: Implications of the Different Post-Translational Endoplasmic Reticulum Organizations of COX-1 and COX-2.
    Akasaka H, So SP, Ruan KH.
    Biochemistry; 2015 Jun 16; 54(23):3707-15. PubMed ID: 25988363
    [Abstract] [Full Text] [Related]

  • 4. COX-2-10aa-PGIS gene therapy improves erectile function in rats after cavernous nerve injury.
    Lin H, Yuan J, Ruan KH, Yang W, Zhang J, Dai Y, Wang R.
    J Sex Med; 2013 Jun 16; 10(6):1476-87. PubMed ID: 23551902
    [Abstract] [Full Text] [Related]

  • 5. Engineering of a protein with cyclooxygenase and prostacyclin synthase activities that converts arachidonic acid to prostacyclin.
    Ruan KH, Deng H, So SP.
    Biochemistry; 2006 Nov 28; 45(47):14003-11. PubMed ID: 17115695
    [Abstract] [Full Text] [Related]

  • 6. A novel single-chain enzyme complex with chain reaction properties rapidly producing thromboxane A2 and exhibiting powerful anti-bleeding functions.
    Li Y, Li QY, Ling QL, So SP, Ruan KH.
    J Cell Mol Med; 2019 Dec 28; 23(12):8343-8354. PubMed ID: 31628732
    [Abstract] [Full Text] [Related]

  • 7. Involvement of prostacyclin synthase in high-fat-diet-induced obesity.
    Sasaki Y, Kuwata H, Akatsu M, Yamakawa Y, Ochiai T, Yoda E, Nakatani Y, Yokoyama C, Hara S.
    Prostaglandins Other Lipid Mediat; 2021 Apr 28; 153():106523. PubMed ID: 33383181
    [Abstract] [Full Text] [Related]

  • 8. Estradiol selectively stimulates endothelial prostacyclin production through estrogen receptor-{alpha}.
    Sobrino A, Oviedo PJ, Novella S, Laguna-Fernandez A, Bueno C, García-Pérez MA, Tarín JJ, Cano A, Hermenegildo C.
    J Mol Endocrinol; 2010 Apr 28; 44(4):237-46. PubMed ID: 20110403
    [Abstract] [Full Text] [Related]

  • 9. Role of prostacyclin synthase in carcinogenesis.
    Sasaki Y, Ochiai T, Takamura M, Kondo Y, Yokoyama C, Hara S.
    Prostaglandins Other Lipid Mediat; 2017 Nov 28; 133():49-52. PubMed ID: 28506876
    [Abstract] [Full Text] [Related]

  • 10. Ozone induces synthesis of systemic prostacyclin by cyclooxygenase-2 dependent mechanism in vivo.
    Schulz S, Ninke S, Watzer B, Nüsing RM.
    Biochem Pharmacol; 2012 Feb 15; 83(4):506-13. PubMed ID: 22155309
    [Abstract] [Full Text] [Related]

  • 11. Augmented renal prostacyclin by intrarenal bicistronic cyclo-oxygenase-1/prostacyclin synthase gene transfer attenuates renal ischemia-reperfusion injury.
    Yang CC, Chen KH, Hsu SP, Chien CT.
    Transplantation; 2013 Dec 27; 96(12):1043-51. PubMed ID: 24092384
    [Abstract] [Full Text] [Related]

  • 12. Oviduct prostacyclin functions as a paracrine factor to augment the development of embryos.
    Huang JC, Goldsby JS, Arbab F, Melhem Z, Aleksic N, Wu KK.
    Hum Reprod; 2004 Dec 27; 19(12):2907-12. PubMed ID: 15492023
    [Abstract] [Full Text] [Related]

  • 13. Extracellular histones disarrange vasoactive mediators release through a COX-NOS interaction in human endothelial cells.
    Pérez-Cremades D, Bueno-Betí C, García-Giménez JL, Ibañez-Cabellos JS, Hermenegildo C, Pallardó FV, Novella S.
    J Cell Mol Med; 2017 Aug 27; 21(8):1584-1592. PubMed ID: 28244682
    [Abstract] [Full Text] [Related]

  • 14. An active triple-catalytic hybrid enzyme engineered by linking cyclo-oxygenase isoform-1 to prostacyclin synthase that can constantly biosynthesize prostacyclin, the vascular protector.
    Ruan KH, So SP, Cervantes V, Wu H, Wijaya C, Jentzen RR.
    FEBS J; 2008 Dec 27; 275(23):5820-9. PubMed ID: 19021758
    [Abstract] [Full Text] [Related]

  • 15. Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1.
    Sasaki Y, Kamiyama S, Kamiyama A, Matsumoto K, Akatsu M, Nakatani Y, Kuwata H, Ishikawa Y, Ishii T, Yokoyama C, Hara S.
    Sci Rep; 2015 Nov 27; 5():17376. PubMed ID: 26611322
    [Abstract] [Full Text] [Related]

  • 16. Cyclooxygenase-2-derived endogenous prostacyclin enhances mouse embryo hatching.
    Huang JC, Wun WS, Goldsby JS, Matijevic-Aleksic N, Wu KK.
    Hum Reprod; 2004 Dec 27; 19(12):2900-6. PubMed ID: 15489241
    [Abstract] [Full Text] [Related]

  • 17. Angiotensin II differentially modulates cyclooxygenase-2, microsomal prostaglandin E2 synthase-1 and prostaglandin I2 synthase expression in adventitial fibroblasts exposed to inflammatory stimuli.
    Galán M, Miguel M, Beltrán AE, Rodríguez C, García-Redondo AB, Rodríguez-Calvo R, Alonso MJ, Martínez-González J, Salaices M.
    J Hypertens; 2011 Mar 27; 29(3):529-36. PubMed ID: 21169864
    [Abstract] [Full Text] [Related]

  • 18. Prostacyclin in endotoxemia-induced acute kidney injury: cyclooxygenase inhibition and renal prostacyclin synthase transgenic mice.
    Wang W, Zolty E, Falk S, Summer S, Stearman R, Geraci M, Schrier R.
    Am J Physiol Renal Physiol; 2007 Oct 27; 293(4):F1131-6. PubMed ID: 17652370
    [Abstract] [Full Text] [Related]

  • 19. Engineering 'Enzymelink' for screening lead compounds to inhibit mPGES-1 while maintaining prostacyclin synthase activity.
    Ruan DT, Tang N, Akasaka H, Lu R, Ruan KH.
    Future Med Chem; 2021 Jul 27; 13(13):1091-1103. PubMed ID: 34080888
    [Abstract] [Full Text] [Related]

  • 20. S-Nitrosylation of Prostacyclin Synthase Instigates Nitrate Cross-Tolerance In Vivo.
    Zhou SN, Lu JX, Wang XQ, Shan MR, Miao Z, Pan GP, Jian X, Li P, Ping S, Pang XY, Bai YP, Liu C, Wang SX.
    Clin Pharmacol Ther; 2019 Jan 27; 105(1):201-209. PubMed ID: 29672839
    [Abstract] [Full Text] [Related]

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