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199 related items for PubMed ID: 29378959

  • 1. Effects of rapamycin on growth hormone receptor knockout mice.
    Fang Y, Hill CM, Darcy J, Reyes-Ordoñez A, Arauz E, McFadden S, Zhang C, Osland J, Gao J, Zhang T, Frank SJ, Javors MA, Yuan R, Kopchick JJ, Sun LY, Chen J, Bartke A.
    Proc Natl Acad Sci U S A; 2018 Feb 13; 115(7):E1495-E1503. PubMed ID: 29378959
    [Abstract] [Full Text] [Related]

  • 2. Rapamycin and mTORC2 inhibition synergistically reduce contraction-stimulated muscle protein synthesis.
    Ogasawara R, Knudsen JR, Li J, Ato S, Jensen TE.
    J Physiol; 2020 Dec 13; 598(23):5453-5466. PubMed ID: 32893874
    [Abstract] [Full Text] [Related]

  • 3. Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy.
    Endicott SJ, Boynton DN, Beckmann LJ, Miller RA.
    Autophagy; 2021 Mar 13; 17(3):612-625. PubMed ID: 32013718
    [Abstract] [Full Text] [Related]

  • 4. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
    Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA.
    Science; 2012 Mar 30; 335(6076):1638-43. PubMed ID: 22461615
    [Abstract] [Full Text] [Related]

  • 5. Roles of mTORC1 and mTORC2 in controlling γδ T1 and γδ T17 differentiation and function.
    Yang Q, Liu X, Liu Q, Guan Z, Luo J, Cao G, Cai R, Li Z, Xu Y, Wu Z, Xu M, Zhang S, Zhang F, Yang H, Lin X, Yang M, Wu Y, Gao Y, Flavell R, Hao J, Yin Z.
    Cell Death Differ; 2020 Jul 30; 27(7):2248-2262. PubMed ID: 32001780
    [Abstract] [Full Text] [Related]

  • 6. mTORC2 acts as a gatekeeper for mTORC1 deficiency-mediated impairments in ILC3 development.
    Deng YF, Wu ST, Peng HY, Tian L, Li YN, Yang Y, Meng M, Huang LL, Xiong PW, Li SY, Yang QL, Wang LL, Li XY, Li LP, Lu XL, Li XH, Wei YL, Xiao ZH, Yu JH, Deng YC.
    Acta Pharmacol Sin; 2023 Nov 30; 44(11):2243-2252. PubMed ID: 37407703
    [Abstract] [Full Text] [Related]

  • 7. Differential roles and activation of mammalian target of rapamycin complexes 1 and 2 during cell migration in prostate cancer cells.
    Venugopal SV, Caggia S, Gambrell-Sanders D, Khan SA.
    Prostate; 2020 Apr 30; 80(5):412-423. PubMed ID: 31995655
    [Abstract] [Full Text] [Related]

  • 8. Mechanistic Target of Rapamycin Signaling Activation Antagonizes Autophagy To Facilitate Zika Virus Replication.
    Sahoo BR, Pattnaik A, Annamalai AS, Franco R, Pattnaik AK.
    J Virol; 2020 Oct 27; 94(22):. PubMed ID: 32878890
    [Abstract] [Full Text] [Related]

  • 9. mTORC1 and mTORC2 play different roles in regulating cardiomyocyte differentiation from embryonic stem cells.
    Zheng B, Wang J, Tang L, Shi J, Zhu D.
    Int J Dev Biol; 2017 Oct 27; 61(1-2):65-72. PubMed ID: 28287249
    [Abstract] [Full Text] [Related]

  • 10. Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan.
    Lamming DW, Mihaylova MM, Katajisto P, Baar EL, Yilmaz OH, Hutchins A, Gultekin Y, Gaither R, Sabatini DM.
    Aging Cell; 2014 Oct 27; 13(5):911-7. PubMed ID: 25059582
    [Abstract] [Full Text] [Related]

  • 11. mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV.
    Yang JY, Madrakhimov SB, Ahn DH, Chang HS, Jung SJ, Nah SK, Park HY, Park TK.
    Cell Commun Signal; 2019 Jun 14; 17(1):64. PubMed ID: 31200728
    [Abstract] [Full Text] [Related]

  • 12. mTORC1 and mTORC2 Converge on the Arp2/3 Complex to Promote KrasG12D-Induced Acinar-to-Ductal Metaplasia and Early Pancreatic Carcinogenesis.
    Zhao Y, Schoeps B, Yao D, Zhang Z, Schuck K, Tissen V, Jäger C, Schlitter AM, van der Kammen R, Ludwig C, D'Haese JG, Raulefs S, Maeritz N, Shen S, Zou X, Krüger A, Kleeff J, Michalski CW, Friess H, Innocenti M, Kong B.
    Gastroenterology; 2021 Apr 14; 160(5):1755-1770.e17. PubMed ID: 33388318
    [Abstract] [Full Text] [Related]

  • 13. TIS21/BTG2 inhibits breast cancer growth and progression by differential regulation of mTORc1 and mTORc2-AKT1-NFAT1-PHLPP2 signaling axis.
    Sundaramoorthy S, Devanand P, Ryu MS, Song KY, Noh DY, Lim IK.
    J Cancer Res Clin Oncol; 2018 Aug 14; 144(8):1445-1462. PubMed ID: 29808317
    [Abstract] [Full Text] [Related]

  • 14. mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons.
    Lee HK, Kwon B, Lemere CA, de la Monte S, Itamura K, Ha AY, Querfurth HW.
    J Alzheimers Dis; 2017 Aug 14; 56(3):1015-1036. PubMed ID: 28035937
    [Abstract] [Full Text] [Related]

  • 15. Hypothalamic mTORC2 is essential for metabolic health and longevity.
    Chellappa K, Brinkman JA, Mukherjee S, Morrison M, Alotaibi MI, Carbajal KA, Alhadeff AL, Perron IJ, Yao R, Purdy CS, DeFelice DM, Wakai MH, Tomasiewicz J, Lin A, Meyer E, Peng Y, Arriola Apelo SI, Puglielli L, Betley JN, Paschos GK, Baur JA, Lamming DW.
    Aging Cell; 2019 Oct 14; 18(5):e13014. PubMed ID: 31373126
    [Abstract] [Full Text] [Related]

  • 16. mTORC1 and mTORC2 differentially promote natural killer cell development.
    Yang C, Tsaih SW, Lemke A, Flister MJ, Thakar MS, Malarkannan S.
    Elife; 2018 May 29; 7():. PubMed ID: 29809146
    [Abstract] [Full Text] [Related]

  • 17. Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver.
    Hinrichs A, Kessler B, Kurome M, Blutke A, Kemter E, Bernau M, Scholz AM, Rathkolb B, Renner S, Bultmann S, Leonhardt H, de Angelis MH, Nagashima H, Hoeflich A, Blum WF, Bidlingmaier M, Wanke R, Dahlhoff M, Wolf E.
    Mol Metab; 2018 May 29; 11():113-128. PubMed ID: 29678421
    [Abstract] [Full Text] [Related]

  • 18. Diverse signaling mechanisms of mTOR complexes: mTORC1 and mTORC2 in forming a formidable relationship.
    Jhanwar-Uniyal M, Wainwright JV, Mohan AL, Tobias ME, Murali R, Gandhi CD, Schmidt MH.
    Adv Biol Regul; 2019 May 29; 72():51-62. PubMed ID: 31010692
    [Abstract] [Full Text] [Related]

  • 19. Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice.
    Makki K, Taront S, Molendi-Coste O, Bouchaert E, Neve B, Eury E, Lobbens S, Labalette M, Duez H, Staels B, Dombrowicz D, Froguel P, Wolowczuk I.
    PLoS One; 2014 May 29; 9(4):e92684. PubMed ID: 24710396
    [Abstract] [Full Text] [Related]

  • 20. Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons.
    Kim SG, Lee S, Kim Y, Park J, Woo D, Kim D, Li Y, Shin W, Kang H, Yook C, Lee M, Kim K, Roh JD, Ryu J, Jung H, Um SM, Yang E, Kim H, Han J, Heo WD, Kim E.
    Nat Commun; 2021 May 11; 12(1):2695. PubMed ID: 33976205
    [Abstract] [Full Text] [Related]

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