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Journal Abstract Search


216 related items for PubMed ID: 29427101

  • 1.
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  • 2. Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1.
    Nitschke L, Coffin SL, Xhako E, El-Najjar DB, Orengo JP, Alcala E, Dai Y, Wan YW, Liu Z, Orr HT, Zoghbi HY.
    JCI Insight; 2021 Feb 08; 6(3):. PubMed ID: 33554954
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  • 3. Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model.
    Pérez Ortiz JM, Mollema N, Toker N, Adamski CJ, O'Callaghan B, Duvick L, Friedrich J, Walters MA, Strasser J, Hawkinson JE, Zoghbi HY, Henzler C, Orr HT, Lagalwar S.
    Neurobiol Dis; 2018 Aug 08; 116():93-105. PubMed ID: 29758256
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  • 4. Beyond the glutamine expansion: influence of posttranslational modifications of ataxin-1 in the pathogenesis of spinocerebellar ataxia type 1.
    Ju H, Kokubu H, Lim J.
    Mol Neurobiol; 2014 Dec 08; 50(3):866-874. PubMed ID: 24752589
    [Abstract] [Full Text] [Related]

  • 5. Ataxin-1 regulates the cerebellar bioenergetics proteome through the GSK3β-mTOR pathway which is altered in Spinocerebellar ataxia type 1 (SCA1).
    Sánchez I, Balagué E, Matilla-Dueñas A.
    Hum Mol Genet; 2016 Sep 15; 25(18):4021-4040. PubMed ID: 27466200
    [Abstract] [Full Text] [Related]

  • 6. Broad distribution of ataxin 1 silencing in rhesus cerebella for spinocerebellar ataxia type 1 therapy.
    Keiser MS, Kordower JH, Gonzalez-Alegre P, Davidson BL.
    Brain; 2015 Dec 15; 138(Pt 12):3555-66. PubMed ID: 26490326
    [Abstract] [Full Text] [Related]

  • 7. Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.
    Lee WS, Lavery L, Rousseaux MWC, Rutledge EB, Jang Y, Wan YW, Wu SR, Kim W, Al-Ramahi I, Rath S, Adamski CJ, Bondar VV, Tewari A, Soleimani S, Mota S, Yalamanchili HK, Orr HT, Liu Z, Botas J, Zoghbi HY.
    EMBO J; 2021 Apr 01; 40(7):e106106. PubMed ID: 33709453
    [Abstract] [Full Text] [Related]

  • 8. Phosphorylation of ATXN1 at Ser776 in the cerebellum.
    Jorgensen ND, Andresen JM, Lagalwar S, Armstrong B, Stevens S, Byam CE, Duvick LA, Lai S, Jafar-Nejad P, Zoghbi HY, Clark HB, Orr HT.
    J Neurochem; 2009 Jul 01; 110(2):675-86. PubMed ID: 19500214
    [Abstract] [Full Text] [Related]

  • 9. SCA1-phosphorylation, a regulator of Ataxin-1 function and pathogenesis.
    Orr HT.
    Prog Neurobiol; 2012 Dec 01; 99(3):179-85. PubMed ID: 22531670
    [Abstract] [Full Text] [Related]

  • 10. PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1.
    Bondar VV, Adamski CJ, Onur TS, Tan Q, Wang L, Diaz-Garcia J, Park J, Orr HT, Botas J, Zoghbi HY.
    Hum Mol Genet; 2018 Aug 15; 27(16):2863-2873. PubMed ID: 29860311
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  • 16. Hsp70/Hsc70 regulates the effect phosphorylation has on stabilizing ataxin-1.
    Jorgensen ND, Andresen JM, Pitt JE, Swenson MA, Zoghbi HY, Orr HT.
    J Neurochem; 2007 Sep 15; 102(6):2040-2048. PubMed ID: 17540008
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  • 18. BDNF is altered in a brain-region specific manner and rescues deficits in Spinocerebellar Ataxia Type 1.
    Rosa JG, Hamel K, Soles A, Sheeler C, Borgenheimer E, Gilliat S, Sbrocco K, Ghanoum F, Handler HP, Forster C, Rainwater O, Cvetanovic M.
    Neurobiol Dis; 2023 Mar 15; 178():106023. PubMed ID: 36724861
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