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406 related items for PubMed ID: 29440451

  • 1. Establishing Transcriptional Signatures to Differentiate PXR-, CAR-, and AhR-Mediated Regulation of Drug Metabolism and Transport Genes in Cryopreserved Human Hepatocytes.
    Moscovitz JE, Kalgutkar AS, Nulick K, Johnson N, Lin Z, Goosen TC, Weng Y.
    J Pharmacol Exp Ther; 2018 May; 365(2):262-271. PubMed ID: 29440451
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  • 3. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
    Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, Ulrichova J, Anzenbacher P, Pavek P.
    Drug Metab Dispos; 2007 Jul; 35(7):1032-41. PubMed ID: 17392393
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  • 4. Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways.
    Li L, Stanton JD, Tolson AH, Luo Y, Wang H.
    Pharm Res; 2009 Apr; 26(4):872-82. PubMed ID: 19034627
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  • 5. Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes.
    Sahi J, Shord SS, Lindley C, Ferguson S, LeCluyse EL.
    J Biochem Mol Toxicol; 2009 Apr; 23(1):43-58. PubMed ID: 19202563
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  • 6. Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes.
    Kandel BA, Thomas M, Winter S, Damm G, Seehofer D, Burk O, Schwab M, Zanger UM.
    Biochim Biophys Acta; 2016 Sep; 1859(9):1218-1227. PubMed ID: 26994748
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  • 7. Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity.
    Chang HY, Chen CJ, Ma WC, Cheng WK, Lin YN, Lee YR, Chen JJ, Lim YP.
    Phytomedicine; 2017 Dec 01; 36():37-49. PubMed ID: 29157826
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  • 10. Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes.
    Rushmore TH, Kong AN.
    Curr Drug Metab; 2002 Oct 01; 3(5):481-90. PubMed ID: 12369894
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  • 11. Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR.
    Kanno Y, Tanuma N, Yazawa S, Zhao S, Inaba M, Nakamura S, Nemoto K, Inouye Y.
    Drug Metab Dispos; 2016 Aug 01; 44(8):1158-63. PubMed ID: 27197997
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  • 12. Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction.
    Hariparsad N, Carr BA, Evers R, Chu X.
    Drug Metab Dispos; 2008 Jun 01; 36(6):1046-55. PubMed ID: 18332078
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  • 13. Role of constitutive androstane receptor in Toll-like receptor-mediated regulation of gene expression of hepatic drug-metabolizing enzymes and transporters.
    Shah P, Guo T, Moore DD, Ghose R.
    Drug Metab Dispos; 2014 Jan 01; 42(1):172-81. PubMed ID: 24194512
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  • 14. Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2.
    Rhodes SP, Otten JN, Hingorani GP, Hartley DP, Franklin RB.
    J Pharmacol Toxicol Methods; 2011 Jan 01; 63(3):223-6. PubMed ID: 21111054
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  • 15. Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification.
    Maglich JM, Stoltz CM, Goodwin B, Hawkins-Brown D, Moore JT, Kliewer SA.
    Mol Pharmacol; 2002 Sep 01; 62(3):638-46. PubMed ID: 12181440
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  • 16. A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor.
    Healan-Greenberg C, Waring JF, Kempf DJ, Blomme EA, Tirona RG, Kim RB.
    Drug Metab Dispos; 2008 Mar 01; 36(3):500-7. PubMed ID: 18096673
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  • 17. Role of CYP3A4 in the regulation of the aryl hydrocarbon receptor by omeprazole sulphide.
    Gerbal-Chaloin S, Pichard-Garcia L, Fabre JM, Sa-Cunha A, Poellinger L, Maurel P, Daujat-Chavanieu M.
    Cell Signal; 2006 May 01; 18(5):740-50. PubMed ID: 16109480
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  • 18. The mycotoxin, patulin, increases the expression of PXR and AhR and their target cytochrome P450s in primary cultured human hepatocytes.
    Ayed-Boussema I, Pascussi JM, Rjiba K, Maurel P, Bacha H, Hassen W.
    Drug Chem Toxicol; 2012 Jul 01; 35(3):241-50. PubMed ID: 21939362
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  • 19. Activation of the aryl hydrocarbon receptor decreases rifampicin-induced CYP3A4 expression in primary human hepatocytes and HepaRG.
    Rasmussen MK, Daujat-Chavanieu M, Gerbal-Chaloin S.
    Toxicol Lett; 2017 Aug 05; 277():1-8. PubMed ID: 28571685
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  • 20. Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.
    Tolson AH, Wang H.
    Adv Drug Deliv Rev; 2010 Oct 30; 62(13):1238-49. PubMed ID: 20727377
    [Abstract] [Full Text] [Related]

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