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108 related items for PubMed ID: 29451686

  • 1. An iminium ion metabolite hampers the production of the pharmacologically active metabolite of a multikinase inhibitor KW-2449 in primates: irreversible inhibition of aldehyde oxidase and covalent binding with endogenous proteins.
    Hosogi J, Ohashi R, Maeda H, Fujita K, Ushiki J, Kuwabara T, Yamamoto Y, Imamura T.
    Biopharm Drug Dispos; 2018 Mar; 39(3):164-174. PubMed ID: 29451686
    [Abstract] [Full Text] [Related]

  • 2. Monoamine oxidase B oxidizes a novel multikinase inhibitor KW-2449 to its iminium ion and aldehyde oxidase further converts it to the oxo-piperazine form in human.
    Hosogi J, Ohashi R, Maeda H, Tashiro S, Fuse E, Yamamoto Y, Kuwabara T.
    Drug Metab Pharmacokinet; 2017 Oct; 32(5):255-264. PubMed ID: 28751116
    [Abstract] [Full Text] [Related]

  • 3. Crystal structures, binding interactions, and ADME evaluation of brain penetrant N-substituted indazole-5-carboxamides as subnanomolar, selective monoamine oxidase B and dual MAO-A/B inhibitors.
    Tzvetkov NT, Stammler HG, Neumann B, Hristova S, Antonov L, Gastreich M.
    Eur J Med Chem; 2017 Feb 15; 127():470-492. PubMed ID: 28107736
    [Abstract] [Full Text] [Related]

  • 4. Species-Specific Involvement of Aldehyde Oxidase and Xanthine Oxidase in the Metabolism of the Pyrimidine-Containing mGlu5-Negative Allosteric Modulator VU0424238 (Auglurant).
    Crouch RD, Blobaum AL, Felts AS, Conn PJ, Lindsley CW.
    Drug Metab Dispos; 2017 Dec 15; 45(12):1245-1259. PubMed ID: 28939686
    [Abstract] [Full Text] [Related]

  • 5. A reactive metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is formed in rat brain in vitro by type B monoamine oxidase.
    Corsini GU, Pintus S, Bocchetta A, Piccardi MP, Del Zompo M.
    J Pharmacol Exp Ther; 1986 Aug 15; 238(2):648-52. PubMed ID: 3488394
    [Abstract] [Full Text] [Related]

  • 6. [3H]Ro 19-6327: a reversible ligand and affinity labelling probe for monoamine oxidase-B.
    Cesura AM, Galva MD, Imhof R, Kyburz E, Picotti GB, Da Prada M.
    Eur J Pharmacol; 1989 Mar 29; 162(3):457-65. PubMed ID: 2744079
    [Abstract] [Full Text] [Related]

  • 7. Species differences in enantioselective 2-oxidations of RS-8359, a selective and reversible MAO-A inhibitor, and cinchona alkaloids by aldehyde oxidase.
    Itoh K, Yamamura M, Takasaki W, Sasaki T, Masubuchi A, Tanaka Y.
    Biopharm Drug Dispos; 2006 Apr 29; 27(3):133-9. PubMed ID: 16400710
    [Abstract] [Full Text] [Related]

  • 8. Synthesis and molecular modeling of some novel hexahydroindazole derivatives as potent monoamine oxidase inhibitors.
    Gökhan-Kelekçi N, Simşek OO, Ercan A, Yelekçi K, Sahin ZS, Işik S, Uçar G, Bilgin AA.
    Bioorg Med Chem; 2009 Sep 15; 17(18):6761-72. PubMed ID: 19682910
    [Abstract] [Full Text] [Related]

  • 9. Stereospecific oxidation of the (S)-enantiomer of RS-8359, a selective and reversible monoamine oxidase A (MAO-A) inhibitor, by aldehyde oxidase.
    Itoh K, Yamamura M, Muramatsu S, Hoshino K, Masubuchi A, Sasaki T, Tanaka Y.
    Xenobiotica; 2005 Jun 15; 35(6):561-73. PubMed ID: 16192108
    [Abstract] [Full Text] [Related]

  • 10. Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers.
    Fisar Z, Hroudová J, Raboch J.
    Neuro Endocrinol Lett; 2010 Jun 15; 31(5):645-56. PubMed ID: 21200377
    [Abstract] [Full Text] [Related]

  • 11. Characterization of the binding of [3H]Ro 41-1049 to the active site of human monoamine oxidase-A.
    Cesura AM, Bös M, Galva MD, Imhof R, Da Prada M.
    Mol Pharmacol; 1990 Mar 15; 37(3):358-66. PubMed ID: 2314388
    [Abstract] [Full Text] [Related]

  • 12. Different sensitivity of mitochondrial and cytosolic monoamine oxidases to in vivo but not in vitro inhibition by specific irreversible inhibitors.
    Moskvitina TA, Medvedev AE.
    Med Sci Monit; 2001 Mar 15; 7(1):17-9. PubMed ID: 11208486
    [Abstract] [Full Text] [Related]

  • 13. Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors.
    Di Pietro O, Alencar N, Esteban G, Viayna E, Szałaj N, Vázquez J, Juárez-Jiménez J, Sola I, Pérez B, Solé M, Unzeta M, Muñoz-Torrero D, Luque FJ.
    Bioorg Med Chem; 2016 Oct 15; 24(20):4835-4854. PubMed ID: 27396685
    [Abstract] [Full Text] [Related]

  • 14. The effect of ethanol consumption on the sensitivity of rat brain monoamine oxidases to the inhibition by pargyline in vivo and in vitro.
    Panova NG, Axenova LN, Medvedev AE.
    Neurobiology (Bp); 2000 Oct 15; 8(3-4):225-30. PubMed ID: 11225512
    [Abstract] [Full Text] [Related]

  • 15. Potentiation of para-hydroxyamphetamine-induced head-twitch response by inhibition of monoamine oxidase type A in the brain.
    Tadano T, Satoh S, Satoh N, Kisara K, Arai Y, Kim SK, Kinemuchi H.
    J Pharmacol Exp Ther; 1989 Jul 15; 250(1):254-60. PubMed ID: 2501477
    [Abstract] [Full Text] [Related]

  • 16. Nitroindazole compounds inhibit the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to neurotoxic pyridinium cations by human monoamine oxidase (MAO).
    Herraiz T, Arán VJ, Guillén H.
    Free Radic Res; 2009 Oct 15; 43(10):975-84. PubMed ID: 19669997
    [Abstract] [Full Text] [Related]

  • 17. [Analysis of ubiquitin-dependent regulation of the monoamine oxidase sensitivity to proteolysis and specific inhibition by pargyline].
    Buneeva OA, Medvedeva MV, Medvedev AE.
    Biomed Khim; 2008 Oct 15; 54(6):720-6. PubMed ID: 19205432
    [Abstract] [Full Text] [Related]

  • 18. Metabolism of homovanillamine to homovanillic acid in guinea pig liver slices.
    Panoutsopoulos G.
    Cell Physiol Biochem; 2005 Oct 15; 15(5):225-32. PubMed ID: 15956785
    [Abstract] [Full Text] [Related]

  • 19. In Vivo Metabolic Trapping Radiotracers for Imaging Monoamine Oxidase-A and -B Enzymatic Activity.
    Brooks AF, Shao X, Quesada CA, Sherman P, Scott PJ, Kilbourn MR.
    ACS Chem Neurosci; 2015 Dec 16; 6(12):1965-71. PubMed ID: 26393369
    [Abstract] [Full Text] [Related]

  • 20. Influence of vesicular storage and monoamine oxidase activity on [11C]phenylephrine kinetics: studies in isolated rat heart.
    Raffel DM, Wieland DM.
    J Nucl Med; 1999 Feb 16; 40(2):323-30. PubMed ID: 10025842
    [Abstract] [Full Text] [Related]

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