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282 related items for PubMed ID: 29463553

  • 1. Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX Models.
    Kogiso M, Qi L, Braun FK, Injac SG, Zhang L, Du Y, Zhang H, Lin FY, Zhao S, Lindsay H, Su JM, Baxter PA, Adesina AM, Liao D, Qian MG, Berg S, Muscal JA, Li XN.
    Clin Cancer Res; 2018 May 01; 24(9):2159-2170. PubMed ID: 29463553
    [Abstract] [Full Text] [Related]

  • 2. Inhibition of Aurora A enhances radiosensitivity in selected lung cancer cell lines.
    Liu N, Wang YA, Sun Y, Ecsedy J, Sun J, Li X, Wang P.
    Respir Res; 2019 Oct 23; 20(1):230. PubMed ID: 31647033
    [Abstract] [Full Text] [Related]

  • 3. The selective Aurora-A kinase inhibitor MLN8237 (alisertib) potently inhibits proliferation of glioblastoma neurosphere tumor stem-like cells and potentiates the effects of temozolomide and ionizing radiation.
    Hong X, O'Donnell JP, Salazar CR, Van Brocklyn JR, Barnett KD, Pearl DK, deCarvalho AC, Ecsedy JA, Brown SL, Mikkelsen T, Lehman NL.
    Cancer Chemother Pharmacol; 2014 May 23; 73(5):983-90. PubMed ID: 24627220
    [Abstract] [Full Text] [Related]

  • 4. The CNS penetrating taxane TPI 287 and the AURKA inhibitor alisertib induce synergistic apoptosis in glioblastoma cells.
    Zumbar CT, Usubalieva A, King PD, Li X, Mifsud CS, Dalton HM, Sak M, Urio S, Bryant WM, McElroy JP, Farmer G, Lehman NL.
    J Neurooncol; 2018 May 23; 137(3):481-492. PubMed ID: 29396807
    [Abstract] [Full Text] [Related]

  • 5. Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and Neck.
    Lee JW, Parameswaran J, Sandoval-Schaefer T, Eoh KJ, Yang DH, Zhu F, Mehra R, Sharma R, Gaffney SG, Perry EB, Townsend JP, Serebriiskii IG, Golemis EA, Issaeva N, Yarbrough WG, Koo JS, Burtness B.
    Clin Cancer Res; 2019 Jun 01; 25(11):3430-3442. PubMed ID: 30755439
    [Abstract] [Full Text] [Related]

  • 6. c-Myc Is a Major Determinant for Antitumor Activity of Aurora A Kinase Inhibitor MLN8237 in Thyroid Cancer.
    Li Y, Li X, Pu J, Yang Q, Guan H, Ji M, Shi B, Chen M, Hou P.
    Thyroid; 2018 Dec 01; 28(12):1642-1654. PubMed ID: 30226440
    [Abstract] [Full Text] [Related]

  • 7. Alisertib demonstrates significant antitumor activity in bevacizumab resistant, patient derived orthotopic models of glioblastoma.
    Kurokawa C, Geekiyanage H, Allen C, Iankov I, Schroeder M, Carlson B, Bakken K, Sarkaria J, Ecsedy JA, D'Assoro A, Friday B, Galanis E.
    J Neurooncol; 2017 Jan 01; 131(1):41-48. PubMed ID: 27816996
    [Abstract] [Full Text] [Related]

  • 8. Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion.
    Do TV, Xiao F, Bickel LE, Klein-Szanto AJ, Pathak HB, Hua X, Howe C, O'Brien SW, Maglaty M, Ecsedy JA, Litwin S, Golemis EA, Schilder RJ, Godwin AK, Connolly DC.
    Oncogene; 2014 Jan 30; 33(5):539-49. PubMed ID: 23334327
    [Abstract] [Full Text] [Related]

  • 9. Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP).
    Maris JM, Morton CL, Gorlick R, Kolb EA, Lock R, Carol H, Keir ST, Reynolds CP, Kang MH, Wu J, Smith MA, Houghton PJ.
    Pediatr Blood Cancer; 2010 Jul 15; 55(1):26-34. PubMed ID: 20108338
    [Abstract] [Full Text] [Related]

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  • 12. The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells.
    Sehdev V, Peng D, Soutto M, Washington MK, Revetta F, Ecsedy J, Zaika A, Rau TT, Schneider-Stock R, Belkhiri A, El-Rifai W.
    Mol Cancer Ther; 2012 Mar 15; 11(3):763-74. PubMed ID: 22302096
    [Abstract] [Full Text] [Related]

  • 13. Cisplatin-resistant cancer cells are sensitive to Aurora kinase A inhibition by alisertib.
    Wang L, Arras J, Katsha A, Hamdan S, Belkhiri A, Ecsedy J, El-Rifai W.
    Mol Oncol; 2017 Aug 15; 11(8):981-995. PubMed ID: 28417568
    [Abstract] [Full Text] [Related]

  • 14. Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer.
    Pitts TM, Bradshaw-Pierce EL, Bagby SM, Hyatt SL, Selby HM, Spreafico A, Tentler JJ, McPhillips K, Klauck PJ, Capasso A, Diamond JR, Davis SL, Tan AC, Arcaroli JJ, Purkey A, Messersmith WA, Ecsedy JA, Eckhardt SG.
    Oncotarget; 2016 Aug 02; 7(31):50290-50301. PubMed ID: 27385211
    [Abstract] [Full Text] [Related]

  • 15. Selective BCL-XL inhibition promotes apoptosis in combination with MLN8237 in medulloblastoma and pediatric glioblastoma cells.
    Levesley J, Steele L, Brüning-Richardson A, Davison A, Zhou J, Ding C, Lawler S, Short SC.
    Neuro Oncol; 2018 Jan 22; 20(2):203-214. PubMed ID: 29016820
    [Abstract] [Full Text] [Related]

  • 16. Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma.
    Xie Y, Zhu S, Zhong M, Yang M, Sun X, Liu J, Kroemer G, Lotze M, Zeh HJ, Kang R, Tang D.
    Gastroenterology; 2017 Nov 22; 153(5):1429-1443.e5. PubMed ID: 28764929
    [Abstract] [Full Text] [Related]

  • 17. Inhibition of Aurora A Kinase in Combination with Chemotherapy Induces Synthetic Lethality and Overcomes Chemoresistance in Myc-Overexpressing Lymphoma.
    Park SI, Lin CP, Ren N, Angus SP, Dittmer DP, Foote M, Parton T, Bhatt AP, Fedoriw YD, Roth DP, Cann ML, Johnson GL, Damania B.
    Target Oncol; 2019 Oct 22; 14(5):563-575. PubMed ID: 31429028
    [Abstract] [Full Text] [Related]

  • 18. Suppressing PD-L1 Expression via AURKA Kinase Inhibition Enhances Natural Killer Cell-Mediated Cytotoxicity against Glioblastoma.
    Nguyen TTT, Gao Q, Mun JY, Zhu Z, Shu C, Naim A, Rogava M, Izar B, Westhoff MA, Karpel-Massler G, Siegelin MD.
    Cells; 2024 Jul 06; 13(13):. PubMed ID: 38995006
    [Abstract] [Full Text] [Related]

  • 19. Inhibition of mitotic Aurora kinase A by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI-N78 cells.
    Yuan CX, Zhou ZW, Yang YX, He ZX, Zhang X, Wang D, Yang T, Wang NJ, Zhao RJ, Zhou SF.
    Drug Des Devel Ther; 2015 Jul 06; 9():487-508. PubMed ID: 25609923
    [Abstract] [Full Text] [Related]

  • 20. Aurora inhibitor MLN8237 in combination with docetaxel enhances apoptosis and anti-tumor activity in mantle cell lymphoma.
    Qi W, Cooke LS, Liu X, Rimsza L, Roe DJ, Manziolli A, Persky DO, Miller TP, Mahadevan D.
    Biochem Pharmacol; 2011 Apr 01; 81(7):881-90. PubMed ID: 21291867
    [Abstract] [Full Text] [Related]

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