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Journal Abstract Search

186 related items for PubMed ID: 29477480

  • 21. A mechanism for the potential proarrhythmic effect of acidosis, bradycardia, and hypokalemia on the blockade of human ether-a-go-go-related gene (HERG) channels.
    Lin C, Cvetanovic I, Ke X, Ranade V, Somberg J.
    Am J Ther; 2005; 12(4):328-36. PubMed ID: 16041196
    [Abstract] [Full Text] [Related]

  • 22. Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit.
    Jacobson I, Carlsson L, Duker G.
    J Pharmacol Toxicol Methods; 2011; 63(1):40-6. PubMed ID: 20451633
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  • 23. Evaluation of Possible Proarrhythmic Potency: Comparison of the Effect of Dofetilide, Cisapride, Sotalol, Terfenadine, and Verapamil on hERG and Native IKr Currents and on Cardiac Action Potential.
    Orvos P, Kohajda Z, Szlovák J, Gazdag P, Árpádffy-Lovas T, Tóth D, Geramipour A, Tálosi L, Jost N, Varró A, Virág L.
    Toxicol Sci; 2019 Apr 01; 168(2):365-380. PubMed ID: 30561737
    [Abstract] [Full Text] [Related]

  • 24. Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes.
    Nalos L, Varkevisser R, Jonsson MK, Houtman MJ, Beekman JD, van der Nagel R, Thomsen MB, Duker G, Sartipy P, de Boer TP, Peschar M, Rook MB, van Veen TA, van der Heyden MA, Vos MA.
    Br J Pharmacol; 2012 Jan 01; 165(2):467-78. PubMed ID: 21718297
    [Abstract] [Full Text] [Related]

  • 25. H(1) antihistamine drug promethazine directly blocks hERG K(+) channel.
    Jo SH, Hong HK, Chong SH, Lee HS, Choe H.
    Pharmacol Res; 2009 Nov 01; 60(5):429-37. PubMed ID: 19497368
    [Abstract] [Full Text] [Related]

  • 26. Minimizing repolarization-related proarrhythmic risk in drug development and clinical practice.
    Farkas AS, Nattel S.
    Drugs; 2010 Mar 26; 70(5):573-603. PubMed ID: 20329805
    [Abstract] [Full Text] [Related]

  • 27. Safety pharmacology studies using EFP and impedance.
    Obergrussberger A, Juhasz K, Thomas U, Stölzle-Feix S, Becker N, Dörr L, Beckler M, Bot C, George M, Fertig N.
    J Pharmacol Toxicol Methods; 2016 Mar 26; 81():223-32. PubMed ID: 27084108
    [Abstract] [Full Text] [Related]

  • 28. Modelling of drug-induced QT-interval prolongation: estimation approaches and translational opportunities.
    Marostica E, Van Ammel K, Teisman A, Boussery K, Van Bocxlaer J, De Ridder F, Gallacher D, Vermeulen A.
    J Pharmacokinet Pharmacodyn; 2015 Dec 26; 42(6):659-79. PubMed ID: 26259721
    [Abstract] [Full Text] [Related]

  • 29. Multi-parametric assessment of cardiomyocyte excitation-contraction coupling using impedance and field potential recording: A tool for cardiac safety assessment.
    Zhang X, Guo L, Zeng H, White SL, Furniss M, Balasubramanian B, Lis E, Lagrutta A, Sannajust F, Zhao LL, Xi B, Wang X, Davis M, Abassi YA.
    J Pharmacol Toxicol Methods; 2016 Dec 26; 81():201-16. PubMed ID: 27282640
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  • 32. IKs inhibitor JNJ303 prolongs the QT interval and perpetuates arrhythmia when combined with enhanced inotropy in the CAVB dog.
    van Bavel JJA, Beekman HDM, van Weperen VYH, van der Linde HJ, van der Heyden MAG, Vos MA.
    Eur J Pharmacol; 2022 Oct 15; 932():175218. PubMed ID: 36007604
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  • 34. Sex-Related Differences in Drug-Induced QT Prolongation and Torsades de Pointes: A New Model System with Human iPSC-CMs.
    Huo J, Wei F, Cai C, Lyn-Cook B, Pang L.
    Toxicol Sci; 2019 Feb 01; 167(2):360-374. PubMed ID: 30247688
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  • 37. Oxycodone is associated with dose-dependent QTc prolongation in patients and low-affinity inhibiting of hERG activity in vitro.
    Fanoe S, Jensen GB, Sjøgren P, Korsgaard MP, Grunnet M.
    Br J Clin Pharmacol; 2009 Feb 01; 67(2):172-9. PubMed ID: 19159406
    [Abstract] [Full Text] [Related]

  • 38. Electrophysiological mechanisms of vandetanib-induced cardiotoxicity: Comparison of action potentials in rabbit Purkinje fibers and pluripotent stem cell-derived cardiomyocytes.
    Lee HA, Hyun SA, Byun B, Chae JH, Kim KS.
    PLoS One; 2018 Feb 01; 13(4):e0195577. PubMed ID: 29630634
    [Abstract] [Full Text] [Related]

  • 39. Electrophysiological safety of sertindole in dogs with normal and remodeled hearts.
    Thomsen MB, Volders PG, Stengl M, Spätjens RL, Beekman JD, Bischoff U, Kall MA, Frederiksen K, Matz J, Vos MA.
    J Pharmacol Exp Ther; 2003 Nov 01; 307(2):776-84. PubMed ID: 12966159
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  • 40. Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations.
    Furutani K, Tsumoto K, Chen IS, Handa K, Yamakawa Y, Sack JT, Kurachi Y.
    J Gen Physiol; 2019 Feb 04; 151(2):214-230. PubMed ID: 30674563
    [Abstract] [Full Text] [Related]

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