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Journal Abstract Search

259 related items for PubMed ID: 2950200

  • 21. Synthesis and biological activities of conformationally restricted, tricyclic nonclassical antifolates as inhibitors of dihydrofolate reductases.
    Gangjee A, Shi J, Queener SF.
    J Med Chem; 1997 Jun 06; 40(12):1930-6. PubMed ID: 9191971
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  • 23. Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents.
    Gangjee A, Vidwans AP, Vasudevan A, Queener SF, Kisliuk RL, Cody V, Li R, Galitsky N, Luft JR, Pangborn W.
    J Med Chem; 1998 Aug 27; 41(18):3426-34. PubMed ID: 9719595
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  • 24. Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.
    Robson C, Meek MA, Grunwaldt JD, Lambert PA, Queener SF, Schmidt D, Griffin RJ.
    J Med Chem; 1997 Sep 12; 40(19):3040-8. PubMed ID: 9301666
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  • 27. Towards species-specific antifolates.
    Chan DC, Anderson AC.
    Curr Med Chem; 2006 Sep 12; 13(4):377-98. PubMed ID: 16475929
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  • 29. New antifolates in clinical development.
    Takimoto CH, Allegra CJ.
    Oncology (Williston Park); 1995 Jul 12; 9(7):649-56, 659 DISC 660, 662, 665. PubMed ID: 8924375
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  • 30. Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate.
    Senkovich O, Schormann N, Chattopadhyay D.
    Acta Crystallogr D Biol Crystallogr; 2009 Jul 12; 65(Pt 7):704-16. PubMed ID: 19564691
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  • 31. Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim.
    Rosowsky A, Papoulis AT, Forsch RA, Queener SF.
    J Med Chem; 1999 Mar 25; 42(6):1007-17. PubMed ID: 10090784
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  • 32. Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells.
    Chen G, Wright JE, Rosowsky A.
    Mol Pharmacol; 1995 Oct 25; 48(4):758-65. PubMed ID: 7476904
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  • 33. Purification and properties of recombinant Pneumocystis carinii dihydrofolate reductase.
    Sirawaraporn W, Edman JC, Santi DV.
    Protein Expr Purif; 1991 Oct 25; 2(5-6):313-6. PubMed ID: 1821803
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  • 34. 6-Substituted 2,4-diaminopyrido[3,2-d]pyrimidine analogues of piritrexim as inhibitors of dihydrofolate reductase from rat liver, Pneumocystis carinii, and Toxoplasma gondii and as antitumor agents.
    Gangjee A, Zhu Y, Queener SF.
    J Med Chem; 1998 Nov 05; 41(23):4533-41. PubMed ID: 9804692
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  • 35. Expression of variant dihydrofolate reductase with decreased binding affinity to antifolates in MOLT-3 human leukemia cell lines resistant to trimetrexate.
    Miyachi H, Takemura Y, Kobayashi H, Ando Y.
    Cancer Lett; 1995 Jan 06; 88(1):93-9. PubMed ID: 7850779
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  • 39. Evidence for a localized conversion of endogenous tetrahydrofolate cofactors to dihydrofolate as an important element in antifolate action in murine leukemia cells.
    Matherly LH, Muench SP.
    Biochem Pharmacol; 1990 Jun 15; 39(12):2005-14. PubMed ID: 2141258
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