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Journal Abstract Search

103 related items for PubMed ID: 29522264

  • 1. A (+)-Larixol Congener with High Affinity and Subtype Selectivity toward TRPC6.
    Häfner S, Burg F, Kannler M, Urban N, Mayer P, Dietrich A, Trauner D, Broichhagen J, Schaefer M.
    ChemMedChem; 2018 May 23; 13(10):1028-1035. PubMed ID: 29522264
    [Abstract] [Full Text] [Related]

  • 2. Pharmacological inhibition of focal segmental glomerulosclerosis-related, gain of function mutants of TRPC6 channels by semi-synthetic derivatives of larixol.
    Urban N, Neuser S, Hentschel A, Köhling S, Rademann J, Schaefer M.
    Br J Pharmacol; 2017 Nov 23; 174(22):4099-4122. PubMed ID: 28800680
    [Abstract] [Full Text] [Related]

  • 3. Identification and Validation of Larixyl Acetate as a Potent TRPC6 Inhibitor.
    Urban N, Wang L, Kwiek S, Rademann J, Kuebler WM, Schaefer M.
    Mol Pharmacol; 2016 Jan 23; 89(1):197-213. PubMed ID: 26500253
    [Abstract] [Full Text] [Related]

  • 4. Validation of an LC-MS/MS Method to Quantify the New TRPC6 Inhibitor SH045 (Larixyl N-methylcarbamate) and Its Application in an Exploratory Pharmacokinetic Study in Mice.
    Chai XN, Ludwig FA, Müglitz A, Schaefer M, Yin HY, Brust P, Regenthal R, Krügel U.
    Pharmaceuticals (Basel); 2021 Mar 13; 14(3):. PubMed ID: 33805686
    [Abstract] [Full Text] [Related]

  • 5. Discovery and characterization of a positive allosteric modulator of transient receptor potential canonical 6 (TRPC6) channels.
    Häfner S, Urban N, Schaefer M.
    Cell Calcium; 2019 Mar 13; 78():26-34. PubMed ID: 30594060
    [Abstract] [Full Text] [Related]

  • 6. A Pharmacokinetic and Metabolism Study of the TRPC6 Inhibitor SH045 in Mice by LC-MS/MS.
    Chai XN, Ludwig FA, Müglitz A, Gong Y, Schaefer M, Regenthal R, Krügel U.
    Int J Mol Sci; 2022 Mar 26; 23(7):. PubMed ID: 35408998
    [Abstract] [Full Text] [Related]

  • 7. Novel pharmacological TRPC inhibitors block hypoxia-induced vasoconstriction.
    Urban N, Hill K, Wang L, Kuebler WM, Schaefer M.
    Cell Calcium; 2012 Feb 26; 51(2):194-206. PubMed ID: 22280812
    [Abstract] [Full Text] [Related]

  • 8. Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels.
    Maier T, Follmann M, Hessler G, Kleemann HW, Hachtel S, Fuchs B, Weissmann N, Linz W, Schmidt T, Löhn M, Schroeter K, Wang L, Rütten H, Strübing C.
    Br J Pharmacol; 2015 Jul 26; 172(14):3650-60. PubMed ID: 25847402
    [Abstract] [Full Text] [Related]

  • 9. Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds.
    Sawamura S, Hatano M, Takada Y, Hino K, Kawamura T, Tanikawa J, Nakagawa H, Hase H, Nakao A, Hirano M, Rotrattanadumrong R, Kiyonaka S, Mori MX, Nishida M, Hu Y, Inoue R, Nagata R, Mori Y.
    Mol Pharmacol; 2016 Mar 26; 89(3):348-63. PubMed ID: 26733543
    [Abstract] [Full Text] [Related]

  • 10. Differences in TRPC3 and TRPC6 channels assembly in mesenteric vascular smooth muscle cells in essential hypertension.
    Álvarez-Miguel I, Cidad P, Pérez-García MT, López-López JR.
    J Physiol; 2017 Mar 01; 595(5):1497-1513. PubMed ID: 27861908
    [Abstract] [Full Text] [Related]

  • 11. Structure of the receptor-activated human TRPC6 and TRPC3 ion channels.
    Tang Q, Guo W, Zheng L, Wu JX, Liu M, Zhou X, Zhang X, Chen L.
    Cell Res; 2018 Jul 01; 28(7):746-755. PubMed ID: 29700422
    [Abstract] [Full Text] [Related]

  • 12. Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel.
    Nishioka K, Nishida M, Ariyoshi M, Jian Z, Saiki S, Hirano M, Nakaya M, Sato Y, Kita S, Iwamoto T, Hirano K, Inoue R, Kurose H.
    Arterioscler Thromb Vasc Biol; 2011 Oct 01; 31(10):2278-86. PubMed ID: 21799177
    [Abstract] [Full Text] [Related]

  • 13. Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice.
    Weissmann N, Sydykov A, Kalwa H, Storch U, Fuchs B, Mederos y Schnitzler M, Brandes RP, Grimminger F, Meissner M, Freichel M, Offermanns S, Veit F, Pak O, Krause KH, Schermuly RT, Brewer AC, Schmidt HH, Seeger W, Shah AM, Gudermann T, Ghofrani HA, Dietrich A.
    Nat Commun; 2012 Jan 31; 3():649. PubMed ID: 22337127
    [Abstract] [Full Text] [Related]

  • 14. The development of automated patch clamp assays for canonical transient receptor potential channels TRPC3, 6, and 7.
    McPate M, Bhalay G, Beckett M, Fairbrother S, Gosling M, Groot-Kormelink PJ, Lane R, Kent T, Van Diepen MT, Tranter P, Verkuyl JM.
    Assay Drug Dev Technol; 2014 Jun 31; 12(5):282-92. PubMed ID: 24906109
    [Abstract] [Full Text] [Related]

  • 15. The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore.
    Washburn DG, Holt DA, Dodson J, McAtee JJ, Terrell LR, Barton L, Manns S, Waszkiewicz A, Pritchard C, Gillie DJ, Morrow DM, Davenport EA, Lozinskaya IM, Guss J, Basilla JB, Negron LK, Klein M, Willette RN, Fries RE, Jensen TC, Xu X, Schnackenberg CG, Marino JP.
    Bioorg Med Chem Lett; 2013 Sep 01; 23(17):4979-84. PubMed ID: 23886683
    [Abstract] [Full Text] [Related]

  • 16. Heteromultimeric TRPC6-TRPC7 channels contribute to arginine vasopressin-induced cation current of A7r5 vascular smooth muscle cells.
    Maruyama Y, Nakanishi Y, Walsh EJ, Wilson DP, Welsh DG, Cole WC.
    Circ Res; 2006 Jun 23; 98(12):1520-7. PubMed ID: 16690880
    [Abstract] [Full Text] [Related]

  • 17. Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells.
    Shi J, Mori E, Mori Y, Mori M, Li J, Ito Y, Inoue R.
    J Physiol; 2004 Dec 01; 561(Pt 2):415-32. PubMed ID: 15579537
    [Abstract] [Full Text] [Related]

  • 18. Increased vascular smooth muscle contractility in TRPC6-/- mice.
    Dietrich A, Mederos Y Schnitzler M, Gollasch M, Gross V, Storch U, Dubrovska G, Obst M, Yildirim E, Salanova B, Kalwa H, Essin K, Pinkenburg O, Luft FC, Gudermann T, Birnbaumer L.
    Mol Cell Biol; 2005 Aug 01; 25(16):6980-9. PubMed ID: 16055711
    [Abstract] [Full Text] [Related]

  • 19. Role of TRPC3 and TRPC6 channels in the myocardial response to stretch: Linking physiology and pathophysiology.
    Yamaguchi Y, Iribe G, Nishida M, Naruse K.
    Prog Biophys Mol Biol; 2017 Nov 01; 130(Pt B):264-272. PubMed ID: 28645743
    [Abstract] [Full Text] [Related]

  • 20. Different binding property of STIM1 and its novel splice variant STIM1L to Orai1, TRPC3, and TRPC6 channels.
    Horinouchi T, Higashi T, Higa T, Terada K, Mai Y, Aoyagi H, Hatate C, Nepal P, Horiguchi M, Harada T, Miwa S.
    Biochem Biophys Res Commun; 2012 Nov 16; 428(2):252-8. PubMed ID: 23068106
    [Abstract] [Full Text] [Related]

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