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96 related items for PubMed ID: 2959824

  • 1. Effects of methotrexate and of the "nonclassical" folate antagonist trimetrexate on human leukemia cells.
    Rodenhuis S, McGuire JJ, Sawicki WL, Bertino JR.
    Leukemia; 1987 Feb; 1(2):116-20. PubMed ID: 2959824
    [Abstract] [Full Text] [Related]

  • 2. N10-propargyl-5,8-dideazafolic acid (CB3717): inhibitory effects on human leukemia cell lines resistant to methotrexate or trimetrexate.
    Takemura Y, Ohnuma T.
    Mt Sinai J Med; 1992 Oct; 59(5):419-24. PubMed ID: 1435841
    [Abstract] [Full Text] [Related]

  • 3. Mechanism of acquired resistance to methotrexate in P388 murine leukemia cells and in their doxorubicin-resistant subline.
    Ramu N, Ramu A, Cole DE, Balis FM, Poplack DG, Pollard HB.
    Isr J Med Sci; 1988 Oct; 24(9-10):477-82. PubMed ID: 2974448
    [Abstract] [Full Text] [Related]

  • 4. Suppression of B cell function by methotrexate and trimetrexate. Evidence for inhibition of purine biosynthesis as a major mechanism of action.
    Rosenthal GJ, Weigand GW, Germolec DR, Blank JA, Luster MI.
    J Immunol; 1988 Jul 15; 141(2):410-6. PubMed ID: 2968399
    [Abstract] [Full Text] [Related]

  • 5. Multidrug resistance in a human leukemic cell line selected for resistance to trimetrexate.
    Arkin H, Ohnuma T, Kamen BA, Holland JF, Vallabhajosula S.
    Cancer Res; 1989 Dec 01; 49(23):6556-61. PubMed ID: 2573416
    [Abstract] [Full Text] [Related]

  • 6. Implications for improved high-dose methotrexate therapeutic effects in cultured human breast cancer and bone marrow cells.
    Bowen D, Southerland WM, Johnson DH, Hawkins M, Hughes DE.
    Cancer Detect Prev; 2000 Dec 01; 24(5):452-8. PubMed ID: 11129987
    [Abstract] [Full Text] [Related]

  • 7. Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.
    Rhee MS, Galivan J, Wright JE, Rosowsky A.
    Mol Pharmacol; 1994 Apr 01; 45(4):783-91. PubMed ID: 7514264
    [Abstract] [Full Text] [Related]

  • 8. Cytotoxicity of trimetrexate against antifolate-resistant human T-cell leukemia cell lines developed in oxidized or reduced folate.
    Miyachi H, Takemura Y, Kobayashi H, Ando Y.
    Jpn J Cancer Res; 1997 Sep 01; 88(9):900-6. PubMed ID: 9369939
    [Abstract] [Full Text] [Related]

  • 9. Inherent resistance of human squamous carcinoma cell lines to methotrexate as a result of decreased polyglutamylation of this drug.
    Pizzorno G, Chang YM, McGuire JJ, Bertino JR.
    Cancer Res; 1989 Oct 01; 49(19):5275-80. PubMed ID: 2475246
    [Abstract] [Full Text] [Related]

  • 10. A human leukemia cell line made resistant to two folate analogues, trimetrexate and N10-propargyl-5,8-dideazafolic acid (CB3717).
    Takemura Y, Ohnuma T, Miyachi H, Sekiguchi S.
    J Cancer Res Clin Oncol; 1991 Oct 01; 117(6):519-25. PubMed ID: 1683871
    [Abstract] [Full Text] [Related]

  • 11. Development of an assay system for the detection and classification of methotrexate resistance in fresh human leukemic cells.
    Rodenhuis S, McGuire JJ, Narayanan R, Bertino JR.
    Cancer Res; 1986 Dec 01; 46(12 Pt 1):6513-9. PubMed ID: 2946404
    [Abstract] [Full Text] [Related]

  • 12. Folate requirements of methotrexate-resistant human acute lymphoblastic leukemia cell lines.
    Kano Y, Ohnuma T, Holland JF.
    Blood; 1986 Aug 01; 68(2):586-91. PubMed ID: 2942201
    [Abstract] [Full Text] [Related]

  • 13. Impact of polyglutamation on sensitivity to raltitrexed and methotrexate in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in CCRF-CEM cell lines.
    Barnes MJ, Estlin EJ, Taylor GA, Aherne GW, Hardcastle A, McGuire JJ, Calvete JA, Lunec J, Pearson AD, Newell DR.
    Clin Cancer Res; 1999 Sep 01; 5(9):2548-58. PubMed ID: 10499632
    [Abstract] [Full Text] [Related]

  • 14. Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
    Diddens H, Niethammer D, Jackson RC.
    Cancer Res; 1983 Nov 01; 43(11):5286-92. PubMed ID: 6225514
    [Abstract] [Full Text] [Related]

  • 15. Inhibition of DNA synthesis in normal and malignant human cells by triazinate (Baker's antifol) and methotrexate.
    Skeel RT, Sawicki WL, Cashmore AR, Bertino JR.
    Cancer Res; 1976 Oct 01; 36(10):3659-64. PubMed ID: 953990
    [Abstract] [Full Text] [Related]

  • 16. Biological activity and intracellular metabolism of ZD1694 in human leukemia cell lines with different resistance mechanisms to antifolate drugs.
    Takemura Y, Kobayashi H, Miyachi H, Gibson W, Kimbell R, Jackman AL.
    Jpn J Cancer Res; 1996 Jul 01; 87(7):773-80. PubMed ID: 8698629
    [Abstract] [Full Text] [Related]

  • 17. Endogenous thymidine and hypoxanthine are a source of error in evaluating methotrexate cytotoxicity by clonogenic assays using undialyzed fetal bovine serum.
    Sobrero AF, Bertino JR.
    Int J Cell Cloning; 1986 Jan 01; 4(1):51-62. PubMed ID: 2936838
    [Abstract] [Full Text] [Related]

  • 18. Circumvention of methotrexate resistance in childhood leukemia subtypes by rationally designed antifolates.
    Rots MG, Pieters R, Peters GJ, van Zantwijk CH, Mauritz R, Noordhuis P, Willey JC, Hählen K, Creutzig U, Janka-Schaub G, Kaspers GJ, Veerman AJ, Jansen G.
    Blood; 1999 Nov 01; 94(9):3121-8. PubMed ID: 10556198
    [Abstract] [Full Text] [Related]

  • 19. Establishment of methotrexate-resistant human acute lymphoblastic leukemia cells in culture and effects of folate antagonists.
    Ohnoshi T, Ohnuma T, Takahashi I, Scanlon K, Kamen BA, Holland JF.
    Cancer Res; 1982 May 01; 42(5):1655-60. PubMed ID: 6978176
    [Abstract] [Full Text] [Related]

  • 20. Biochemical and growth inhibition studies of methotrexate and aminopterin analogues containing a tetrazole ring in place of the gamma-carboxyl group.
    McGuire JJ, Russell CA, Bolanowska WE, Freitag CM, Jones CS, Kalman TI.
    Cancer Res; 1990 Mar 15; 50(6):1726-31. PubMed ID: 2306727
    [Abstract] [Full Text] [Related]

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