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117 related items for PubMed ID: 29679549

  • 1. CHM-1, a novel microtubule-destabilizing agent exhibits antitumor activity via inducing the expression of SIRT2 in human breast cancer cells.
    Liu CW, Lin YC, Hung CM, Liu BL, Kuo SC, Ho CT, Way TD, Hung CH.
    Chem Biol Interact; 2018 Jun 01; 289():98-108. PubMed ID: 29679549
    [Abstract] [Full Text] [Related]

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  • 3. CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells.
    Lee JC, Chou LC, Huang CH, Chung JG, Huang LJ, Lee KH, Hung MC, Way TD, Kuo SC.
    Eur J Pharmacol; 2011 Nov 16; 670(1):96-104. PubMed ID: 21907193
    [Abstract] [Full Text] [Related]

  • 4. SIRT2 inactivation reveals a subset of hyperacetylated perinuclear microtubules inaccessible to HDAC6.
    Skoge RH, Ziegler M.
    J Cell Sci; 2016 Aug 01; 129(15):2972-82. PubMed ID: 27311481
    [Abstract] [Full Text] [Related]

  • 5. CWF-145, a novel synthetic quinolone derivative exerts potent antimitotic activity against human prostate cancer: Rapamycin enhances antimitotic drug-induced apoptosis through the inhibition of Akt/mTOR pathway.
    Hung CM, Lin YC, Liu LC, Kuo SC, Ho CT, Way TD.
    Chem Biol Interact; 2016 Dec 25; 260():1-12. PubMed ID: 27769712
    [Abstract] [Full Text] [Related]

  • 6. Modulation Of Microtubule Acetylation By The Interplay Of TPPP/p25, SIRT2 And New Anticancer Agents With Anti-SIRT2 Potency.
    Szabó A, Oláh J, Szunyogh S, Lehotzky A, Szénási T, Csaplár M, Schiedel M, Lőw P, Jung M, Ovádi J.
    Sci Rep; 2017 Dec 06; 7(1):17070. PubMed ID: 29213065
    [Abstract] [Full Text] [Related]

  • 7. YSL-12, a novel microtubule-destabilizing agent, exerts potent anti-tumor activity against colon cancer in vitro and in vivo.
    Cai D, Qiu Z, Yao W, Liu Y, Huang H, Liao S, Luo Q, Xie L, Lin Z.
    Cancer Chemother Pharmacol; 2016 Jun 06; 77(6):1217-29. PubMed ID: 27107592
    [Abstract] [Full Text] [Related]

  • 8. Inhibition of the insulin-like growth factor 1 receptor by CHM-1 blocks proliferation of glioblastoma multiforme cells.
    Lin YC, Hou SC, Hung CM, Lin JN, Chen WC, Ho CT, Kuo SC, Way TD.
    Chem Biol Interact; 2015 Apr 25; 231():119-26. PubMed ID: 25643584
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents.
    Conesa-Milián L, Falomir E, Murga J, Carda M, Meyen E, Liekens S, Alberto Marco J.
    Eur J Med Chem; 2018 Mar 10; 147():183-193. PubMed ID: 29432949
    [Abstract] [Full Text] [Related]

  • 10. CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation.
    Tsai AC, Pan SL, Sun HL, Wang CY, Peng CY, Wang SW, Chang YL, Kuo SC, Lee KH, Teng CM.
    J Biol Chem; 2010 Feb 19; 285(8):5497-506. PubMed ID: 20007968
    [Abstract] [Full Text] [Related]

  • 11. Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors.
    Yang L, Ma X, Yuan C, He Y, Li L, Fang S, Xia W, He T, Qian S, Xu Z, Li G, Wang Z.
    Eur J Med Chem; 2017 Jul 07; 134():230-241. PubMed ID: 28415012
    [Abstract] [Full Text] [Related]

  • 12. Leiodermatolide, a novel marine natural product, has potent cytotoxic and antimitotic activity against cancer cells, appears to affect microtubule dynamics, and exhibits antitumor activity.
    Guzmán EA, Xu Q, Pitts TP, Mitsuhashi KO, Baker C, Linley PA, Oestreicher J, Tendyke K, Winder PL, Suh EM, Wright AE.
    Int J Cancer; 2016 Nov 01; 139(9):2116-26. PubMed ID: 27376928
    [Abstract] [Full Text] [Related]

  • 13. Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin.
    Nahhas F, Dryden SC, Abrams J, Tainsky MA.
    Mol Cell Biochem; 2007 Sep 01; 303(1-2):221-30. PubMed ID: 17516032
    [Abstract] [Full Text] [Related]

  • 14. Antimitotic activities of 2-phenylindole-3-carbaldehydes in human breast cancer cells.
    Kaufmann D, Pojarová M, Vogel S, Liebl R, Gastpar R, Gross D, Nishino T, Pfaller T, von Angerer E.
    Bioorg Med Chem; 2007 Aug 01; 15(15):5122-36. PubMed ID: 17533132
    [Abstract] [Full Text] [Related]

  • 15. The quinolone derivative CHM-1 inhibits murine WEHI-3 leukemia in BALB/c mice in vivo.
    Lai TY, Yang JS, Wu PP, Huang WW, Kuo SC, Ma CY, Gibson Wood W, Chung JG.
    Leuk Lymphoma; 2010 Nov 01; 51(11):2098-102. PubMed ID: 20846096
    [Abstract] [Full Text] [Related]

  • 16. Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies.
    Chowdhury S, Sripathy S, Webster A, Park A, Lao U, Hsu JH, Loe T, Bedalov A, Simon JA.
    Molecules; 2020 Jan 21; 25(3):. PubMed ID: 31973227
    [Abstract] [Full Text] [Related]

  • 17. 2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol (SQ0814061), a novel microtubule inhibitor, evokes G2/M cell cycle arrest and apoptosis in human breast cancer cells.
    Xu J, Zuo D, Qi H, Shen Q, Bai Z, Han M, Li Z, Zhang W, Wu Y.
    Biomed Pharmacother; 2016 Mar 21; 78():308-321. PubMed ID: 26898456
    [Abstract] [Full Text] [Related]

  • 18. Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents.
    Devkota L, Lin CM, Strecker TE, Wang Y, Tidmore JK, Chen Z, Guddneppanavar R, Jelinek CJ, Lopez R, Liu L, Hamel E, Mason RP, Chaplin DJ, Trawick ML, Pinney KG.
    Bioorg Med Chem; 2016 Mar 01; 24(5):938-956. PubMed ID: 26852340
    [Abstract] [Full Text] [Related]

  • 19. Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo.
    HuangFu WC, Chao MW, Cheng CC, Wei YC, Wu YW, Liou JP, Hsiao G, Lee YC, Yang CR.
    Sci Rep; 2017 Feb 09; 7():42291. PubMed ID: 28181578
    [Abstract] [Full Text] [Related]

  • 20. Cytotoxic activity of the histone deacetylase inhibitor panobinostat (LBH589) in anaplastic thyroid cancer in vitro and in vivo.
    Catalano MG, Pugliese M, Gargantini E, Grange C, Bussolati B, Asioli S, Bosco O, Poli R, Compagnone A, Bandino A, Mainini F, Fortunati N, Boccuzzi G.
    Int J Cancer; 2012 Feb 01; 130(3):694-704. PubMed ID: 21400508
    [Abstract] [Full Text] [Related]

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