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115 related items for PubMed ID: 29692266

  • 1. Insights into the Biological Evaluation of Pterocarpanquinones and Carbapterocarpans with Anti-tumor Activity against MDR Leukemias.
    Rumjanek VM, Maia RC, Salustiano EJ, Costa PRR.
    Anticancer Agents Med Chem; 2019; 19(1):29-37. PubMed ID: 29692266
    [Abstract] [Full Text] [Related]

  • 2. The therapeutical potential of a novel pterocarpanquinone LQB-118 to target inhibitor of apoptosis proteins in acute myeloid leukemia cells.
    de Souza Reis FR, de Faria FC, Castro CP, de Souza PS, da Cunha Vasconcelos F, Bello RD, da Silva AJ, Costa PR, Maia RC.
    Anticancer Agents Med Chem; 2013 Feb; 13(2):341-51. PubMed ID: 22721384
    [Abstract] [Full Text] [Related]

  • 3. 11a-N-Tosyl-5-deoxi-pterocarpan (LQB-223), a promising prototype for targeting MDR leukemia cell lines.
    Buarque CD, Salustiano EJ, Fraga KC, Alves BR, Costa PR.
    Eur J Med Chem; 2014 May 06; 78():190-7. PubMed ID: 24681983
    [Abstract] [Full Text] [Related]

  • 4. The pterocarpanquinone LQB 118 induces apoptosis in tumor cells through the intrinsic pathway and the endoplasmic reticulum stress pathway.
    de Sá Bacelar T, da Silva AJ, Costa PR, Rumjanek VM.
    Anticancer Drugs; 2013 Jan 06; 24(1):73-83. PubMed ID: 22960938
    [Abstract] [Full Text] [Related]

  • 5. LQB-118, a pterocarpanquinone structurally related to lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone]: a novel class of agent with high apoptotic effect in chronic myeloid leukemia cells.
    Maia RC, Vasconcelos FC, de Sá Bacelar T, Salustiano EJ, da Silva LF, Pereira DL, Moellman-Coelho A, Netto CD, da Silva AJ, Rumjanek VM, Costa PR.
    Invest New Drugs; 2011 Dec 06; 29(6):1143-55. PubMed ID: 20499132
    [Abstract] [Full Text] [Related]

  • 6. The LQB-223 Compound Modulates Antiapoptotic Proteins and Impairs Breast Cancer Cell Growth and Migration.
    Lemos LGT, Longo GMDC, Mendonça BDS, Robaina MC, Brum MCM, Cirilo CA, Gimba ERP, Costa PRR, Buarque CD, Nestal de Moraes G, Maia RC.
    Int J Mol Sci; 2019 Oct 12; 20(20):. PubMed ID: 31614718
    [Abstract] [Full Text] [Related]

  • 7. The orally active pterocarpanquinone LQB-118 exhibits cytotoxicity in prostate cancer cell and tumor models through cellular redox stress.
    Martino T, Kudrolli TA, Kumar B, Salviano I, Mencalha A, Coelho MGP, Justo G, Costa PRR, Sabino KCC, Lupold SE.
    Prostate; 2018 Feb 12; 78(2):140-151. PubMed ID: 29105806
    [Abstract] [Full Text] [Related]

  • 8. 11a-N-tosyl-5-carbapterocarpans: Synthesis, antineoplastic evaluation and in silico prediction of ADMETox properties.
    Mendes JA, Salustiano EJ, Pires CS, Oliveira T, Barcellos JCF, Cifuentes JMC, Costa PRR, Rennó MN, Buarque CD.
    Bioorg Chem; 2018 Oct 12; 80():585-590. PubMed ID: 30036814
    [Abstract] [Full Text] [Related]

  • 9. Pterocarpanquinones, aza-pterocarpanquinone and derivatives: synthesis, antineoplasic activity on human malignant cell lines and antileishmanial activity on Leishmania amazonensis.
    Buarque CD, Militão GC, Lima DJ, Costa-Lotufo LV, Pessoa C, de Moraes MO, Cunha-Junior EF, Torres-Santos EC, Netto CD, Costa PR.
    Bioorg Med Chem; 2011 Nov 15; 19(22):6885-91. PubMed ID: 22000949
    [Abstract] [Full Text] [Related]

  • 10. 11a-N-Tosyl-5-deoxi-pterocarpan, LQB-223, a novel compound with potent antineoplastic activity toward breast cancer cells with different phenotypes.
    Lemos LG, Nestal de Moraes G, Delbue D, Vasconcelos Fda C, Bernardo PS, Lam EW, Buarque CD, Costa PR, Maia RC.
    J Cancer Res Clin Oncol; 2016 Oct 15; 142(10):2119-30. PubMed ID: 27520309
    [Abstract] [Full Text] [Related]

  • 11. The pterocarpanquinone LQB-118 induces apoptosis in acute myeloid leukemia cells of distinct molecular subtypes and targets FoxO3a and FoxM1 transcription factors.
    Nestal de Moraes G, Castro CP, Salustiano EJ, Dumas ML, Costas F, Lam EW, Costa PR, Maia RC.
    Int J Oncol; 2014 Nov 15; 45(5):1949-58. PubMed ID: 25174716
    [Abstract] [Full Text] [Related]

  • 12. In vitro and in vivo antineoplastic and immunological effects of pterocarpanquinone LQB-118.
    Salustiano EJ, Dumas ML, Silva-Santos GG, Netto CD, Costa PR, Rumjanek VM.
    Invest New Drugs; 2016 Oct 15; 34(5):541-51. PubMed ID: 27189479
    [Abstract] [Full Text] [Related]

  • 13. NFκB pathway and microRNA-9 and -21 are involved in sensitivity to the pterocarpanquinone LQB-118 in different CML cell lines.
    de Faria FC, Leal ME, Bernardo PS, Costa PR, Maia RC.
    Anticancer Agents Med Chem; 2015 Oct 15; 15(3):345-52. PubMed ID: 25964959
    [Abstract] [Full Text] [Related]

  • 14. The pterocarpanquinone LQB-118 inhibits tumor cell proliferation by downregulation of c-Myc and cyclins D1 and B1 mRNA and upregulation of p21 cell cycle inhibitor expression.
    Martino T, Magalhães FC, Justo GA, Coelho MG, Netto CD, Costa PR, Sabino KC.
    Bioorg Med Chem; 2014 Jun 15; 22(12):3115-22. PubMed ID: 24794748
    [Abstract] [Full Text] [Related]

  • 15. Anti-inflammatory properties of pterocarpanquinone LQB-118 in mice.
    Riça IG, Netto CD, Rennó MN, Abreu PA, Costa PRR, da Silva AJM, Cavalcante MCM.
    Bioorg Med Chem; 2016 Sep 15; 24(18):4415-4423. PubMed ID: 27492193
    [Abstract] [Full Text] [Related]

  • 16. Medicarpin and millepurpan, two flavonoids isolated from Medicago sativa, induce apoptosis and overcome multidrug resistance in leukemia P388 cells.
    Gatouillat G, Magid AA, Bertin E, El btaouri H, Morjani H, Lavaud C, Madoulet C.
    Phytomedicine; 2015 Dec 01; 22(13):1186-94. PubMed ID: 26598918
    [Abstract] [Full Text] [Related]

  • 17. A newly synthesized nickel chelate can selectively target and overcome multidrug resistance in cancer through redox imbalance both in vivo and in vitro.
    Banerjee K, Biswas MK, Choudhuri SK.
    J Biol Inorg Chem; 2017 Dec 01; 22(8):1223-1249. PubMed ID: 29063196
    [Abstract] [Full Text] [Related]

  • 18. New pterocarpanquinones: synthesis, antineoplasic activity on cultured human malignant cell lines and TNF-alpha modulation in human PBMC cells.
    Netto CD, da Silva AJ, Salustiano EJ, Bacelar TS, Riça IG, Cavalcante MC, Rumjanek VM, Costa PR.
    Bioorg Med Chem; 2010 Feb 15; 18(4):1610-6. PubMed ID: 20117936
    [Abstract] [Full Text] [Related]

  • 19. LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis.
    Ribeiro GA, Cunha-Júnior EF, Pinheiro RO, da-Silva SA, Canto-Cavalheiro MM, da Silva AJ, Costa PR, Netto CD, Melo RC, Almeida-Amaral EE, Torres-Santos EC.
    J Antimicrob Chemother; 2013 Apr 15; 68(4):789-99. PubMed ID: 23288404
    [Abstract] [Full Text] [Related]

  • 20. H1, a derivative of Tetrandrine, exerts anti-MDR activity by initiating intrinsic apoptosis pathway and inhibiting the activation of Erk1/2 and Akt1/2.
    Wei N, Liu GT, Chen XG, Liu Q, Wang FP, Sun H.
    Biochem Pharmacol; 2011 Dec 01; 82(11):1593-603. PubMed ID: 21864508
    [Abstract] [Full Text] [Related]

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