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352 related items for PubMed ID: 29718973

  • 1. Abrogation of transforming growth factor-β-induced tissue fibrosis in TBRIcaCol1a2Cre transgenic mice by the second generation tyrosine kinase inhibitor SKI-606 (Bosutinib).
    Wermuth PJ, Jimenez SA.
    PLoS One; 2018; 13(5):e0196559. PubMed ID: 29718973
    [Abstract] [Full Text] [Related]

  • 2. Simultaneous inhibition of c-Abl and Src kinases abrogates the exaggerated expression of profibrotic genes in cultured systemic sclerosis dermal fibroblasts.
    Piera-Velazquez S, Jimenez SA.
    Clin Exp Rheumatol; 2018; 36 Suppl 113(4):36-44. PubMed ID: 30277861
    [Abstract] [Full Text] [Related]

  • 3. Novel Src/Abl tyrosine kinase inhibitor bosutinib suppresses neuroblastoma growth via inhibiting Src/Abl signaling.
    Bieerkehazhi S, Chen Z, Zhao Y, Yu Y, Zhang H, Vasudevan SA, Woodfield SE, Tao L, Yi JS, Muscal JA, Pang JC, Guan S, Zhang H, Nuchtern JG, Li H, Li H, Yang J.
    Oncotarget; 2017 Jan 03; 8(1):1469-1480. PubMed ID: 27903968
    [Abstract] [Full Text] [Related]

  • 4. Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells.
    Remsing Rix LL, Rix U, Colinge J, Hantschel O, Bennett KL, Stranzl T, Müller A, Baumgartner C, Valent P, Augustin M, Till JH, Superti-Furga G.
    Leukemia; 2009 Mar 03; 23(3):477-85. PubMed ID: 19039322
    [Abstract] [Full Text] [Related]

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  • 6. A Src/Abl kinase inhibitor, SKI-606, blocks breast cancer invasion, growth, and metastasis in vitro and in vivo.
    Jallal H, Valentino ML, Chen G, Boschelli F, Ali S, Rabbani SA.
    Cancer Res; 2007 Feb 15; 67(4):1580-8. PubMed ID: 17308097
    [Abstract] [Full Text] [Related]

  • 7. Second-generation Src/Abl inhibitor bosutinib effectively induces apoptosis in human esophageal squamous cell carcinoma (ESCC) cells via inhibiting Src/Abl signaling.
    Ha YNE, Dai Y, Wufuer D, Pidayi M, Anasihan G, Chen L.
    Neoplasma; 2020 Jan 15; 67(1):54-60. PubMed ID: 31777258
    [Abstract] [Full Text] [Related]

  • 8. The transcription factor GLI2 as a downstream mediator of transforming growth factor-β-induced fibroblast activation in SSc.
    Liang R, Šumová B, Cordazzo C, Mallano T, Zhang Y, Wohlfahrt T, Dees C, Ramming A, Krasowska D, Michalska-Jakubus M, Distler O, Schett G, Šenolt L, Distler JH.
    Ann Rheum Dis; 2017 Apr 15; 76(4):756-764. PubMed ID: 27793816
    [Abstract] [Full Text] [Related]

  • 9. Intracellular TGF-beta receptor blockade abrogates Smad-dependent fibroblast activation in vitro and in vivo.
    Ishida W, Mori Y, Lakos G, Sun L, Shan F, Bowes S, Josiah S, Lee WC, Singh J, Ling LE, Varga J.
    J Invest Dermatol; 2006 Aug 15; 126(8):1733-44. PubMed ID: 16741519
    [Abstract] [Full Text] [Related]

  • 10. Abrogation of transforming growth factor-β-induced tissue fibrosis in mice with a global genetic deletion of Nox4.
    Wermuth PJ, Mendoza FA, Jimenez SA.
    Lab Invest; 2019 Apr 15; 99(4):470-482. PubMed ID: 30470772
    [Abstract] [Full Text] [Related]

  • 11. Spleen tyrosine kinase (Syk) inhibitor fostamatinib limits tissue damage and fibrosis in a bleomycin-induced scleroderma mouse model.
    Pamuk ON, Can G, Ayvaz S, Karaca T, Pamuk GE, Demirtas S, Tsokos GC.
    Clin Exp Rheumatol; 2015 Apr 15; 33(4 Suppl 91):S15-22. PubMed ID: 26148346
    [Abstract] [Full Text] [Related]

  • 12. Tribbles homologue 3 stimulates canonical TGF-β signalling to regulate fibroblast activation and tissue fibrosis.
    Tomcik M, Palumbo-Zerr K, Zerr P, Sumova B, Avouac J, Dees C, Distler A, Becvar R, Distler O, Schett G, Senolt L, Distler JH.
    Ann Rheum Dis; 2016 Mar 15; 75(3):609-16. PubMed ID: 25603829
    [Abstract] [Full Text] [Related]

  • 13. Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis.
    Akhmetshina A, Venalis P, Dees C, Busch N, Zwerina J, Schett G, Distler O, Distler JH.
    Arthritis Rheum; 2009 Jan 15; 60(1):219-24. PubMed ID: 19116940
    [Abstract] [Full Text] [Related]

  • 14. Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis.
    Tomcik M, Zerr P, Pitkowski J, Palumbo-Zerr K, Avouac J, Distler O, Becvar R, Senolt L, Schett G, Distler JH.
    Ann Rheum Dis; 2014 Jun 15; 73(6):1215-22. PubMed ID: 23661493
    [Abstract] [Full Text] [Related]

  • 15. In vivo investigations on anti-fibrotic potential of proteasome inhibition in lung and skin fibrosis.
    Fineschi S, Bongiovanni M, Donati Y, Djaafar S, Naso F, Goffin L, Argiroffo CB, Pache JC, Dayer JM, Ferrari-Lacraz S, Chizzolini C.
    Am J Respir Cell Mol Biol; 2008 Oct 15; 39(4):458-65. PubMed ID: 18458239
    [Abstract] [Full Text] [Related]

  • 16. Effects of thalidomide on Th17, Treg cells and TGF-β1/Smad3 pathway in a mouse model of systemic sclerosis.
    Lu Y, Zhao C, Lei L, Tao Z, Zheng L, Wen J, Li X.
    Int J Rheum Dis; 2020 Mar 15; 23(3):406-419. PubMed ID: 31840939
    [Abstract] [Full Text] [Related]

  • 17. SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice.
    Golas JM, Arndt K, Etienne C, Lucas J, Nardin D, Gibbons J, Frost P, Ye F, Boschelli DH, Boschelli F.
    Cancer Res; 2003 Jan 15; 63(2):375-81. PubMed ID: 12543790
    [Abstract] [Full Text] [Related]

  • 18. Src as a Therapeutic Target in Biliary Tract Cancer.
    Nam AR, Kim JW, Park JE, Bang JH, Jin MH, Lee KH, Kim TY, Han SW, Im SA, Kim TY, Oh DY, Bang YJ.
    Mol Cancer Ther; 2016 Jul 15; 15(7):1515-24. PubMed ID: 27196758
    [Abstract] [Full Text] [Related]

  • 19. Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma.
    Sonnylal S, Denton CP, Zheng B, Keene DR, He R, Adams HP, Vanpelt CS, Geng YJ, Deng JM, Behringer RR, de Crombrugghe B.
    Arthritis Rheum; 2007 Jan 15; 56(1):334-44. PubMed ID: 17195237
    [Abstract] [Full Text] [Related]

  • 20. Persistent Cdk2 inactivation drives growth arrest of BCR-ABL-expressing cells in response to dual inhibitor of SRC and ABL kinases SKI606.
    Mancini M, Brusa G, Zuffa E, Corrado P, Martinelli G, Grafone T, Barbieri E, Santucci MA.
    Leuk Res; 2007 Jul 15; 31(7):979-87. PubMed ID: 17129604
    [Abstract] [Full Text] [Related]

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