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280 related items for PubMed ID: 29758256

  • 1. Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model.
    Pérez Ortiz JM, Mollema N, Toker N, Adamski CJ, O'Callaghan B, Duvick L, Friedrich J, Walters MA, Strasser J, Hawkinson JE, Zoghbi HY, Henzler C, Orr HT, Lagalwar S.
    Neurobiol Dis; 2018 Aug; 116():93-105. PubMed ID: 29758256
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  • 2. Phosphorylation of ATXN1 at Ser776 in the cerebellum.
    Jorgensen ND, Andresen JM, Lagalwar S, Armstrong B, Stevens S, Byam CE, Duvick LA, Lai S, Jafar-Nejad P, Zoghbi HY, Clark HB, Orr HT.
    J Neurochem; 2009 Jul; 110(2):675-86. PubMed ID: 19500214
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  • 3. Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1.
    Nitschke L, Coffin SL, Xhako E, El-Najjar DB, Orengo JP, Alcala E, Dai Y, Wan YW, Liu Z, Orr HT, Zoghbi HY.
    JCI Insight; 2021 Feb 08; 6(3):. PubMed ID: 33554954
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  • 4. Dopamine D2 receptor signaling modulates mutant ataxin-1 S776 phosphorylation and aggregation.
    Hearst SM, Lopez ME, Shao Q, Liu Y, Vig PJ.
    J Neurochem; 2010 Aug 08; 114(3):706-16. PubMed ID: 20477910
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  • 8. Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways.
    Ingram M, Wozniak EAL, Duvick L, Yang R, Bergmann P, Carson R, O'Callaghan B, Zoghbi HY, Henzler C, Orr HT.
    Neuron; 2016 Mar 16; 89(6):1194-1207. PubMed ID: 26948890
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  • 9. The design and delivery of a PKA inhibitory polypeptide to treat SCA1.
    Hearst SM, Shao Q, Lopez M, Raucher D, Vig PJ.
    J Neurochem; 2014 Oct 16; 131(1):101-14. PubMed ID: 24903464
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  • 10. BDNF is altered in a brain-region specific manner and rescues deficits in Spinocerebellar Ataxia Type 1.
    Rosa JG, Hamel K, Soles A, Sheeler C, Borgenheimer E, Gilliat S, Sbrocco K, Ghanoum F, Handler HP, Forster C, Rainwater O, Cvetanovic M.
    Neurobiol Dis; 2023 Mar 16; 178():106023. PubMed ID: 36724861
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  • 12. Indirect Negative Effect of Mutant Ataxin-1 on Short- and Long-Term Synaptic Plasticity in Mouse Models of Spinocerebellar Ataxia Type 1.
    Shuvaev AN, Belozor OS, Mozhei OI, Shuvaev AN, Fritsler YV, Khilazheva ED, Mosyagina AI, Hirai H, Teschemacher AG, Kasparov S.
    Cells; 2022 Jul 20; 11(14):. PubMed ID: 35883691
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  • 13. BIIB021, a synthetic Hsp90 inhibitor, induces mutant ataxin-1 degradation through the activation of heat shock factor 1.
    Ding Y, Adachi H, Katsuno M, Sahashi K, Kondo N, Iida M, Tohnai G, Nakatsuji H, Sobue G.
    Neuroscience; 2016 Jul 07; 327():20-31. PubMed ID: 27058144
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  • 16. Pre-ataxic loss of intrinsic plasticity and motor learning in a mouse model of SCA1.
    Osório C, White JJ, Lu H, Beekhof GC, Fiocchi FR, Andriessen CA, Dijkhuizen S, Post L, Schonewille M.
    Brain; 2023 Jun 01; 146(6):2332-2345. PubMed ID: 36352508
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  • 17. Sphingolipid metabolism governs Purkinje cell patterned degeneration in Atxn1[82Q]/+ mice.
    Blot FGC, Krijnen WHJJ, Den Hoedt S, Osório C, White JJ, Mulder MT, Schonewille M.
    Proc Natl Acad Sci U S A; 2021 Sep 07; 118(36):. PubMed ID: 34479994
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  • 18. Purkinje cell ataxin-1 modulates climbing fiber synaptic input in developing and adult mouse cerebellum.
    Ebner BA, Ingram MA, Barnes JA, Duvick LA, Frisch JL, Clark HB, Zoghbi HY, Ebner TJ, Orr HT.
    J Neurosci; 2013 Mar 27; 33(13):5806-20. PubMed ID: 23536093
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  • 19. Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.
    Lee WS, Lavery L, Rousseaux MWC, Rutledge EB, Jang Y, Wan YW, Wu SR, Kim W, Al-Ramahi I, Rath S, Adamski CJ, Bondar VV, Tewari A, Soleimani S, Mota S, Yalamanchili HK, Orr HT, Liu Z, Botas J, Zoghbi HY.
    EMBO J; 2021 Apr 01; 40(7):e106106. PubMed ID: 33709453
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  • 20. Hsp70/Hsc70 regulates the effect phosphorylation has on stabilizing ataxin-1.
    Jorgensen ND, Andresen JM, Pitt JE, Swenson MA, Zoghbi HY, Orr HT.
    J Neurochem; 2007 Sep 01; 102(6):2040-2048. PubMed ID: 17540008
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