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304 related items for PubMed ID: 29760186

  • 1. Hypertrophic cardiomyopathy mutations increase myofilament Ca2+ buffering, alter intracellular Ca2+ handling, and stimulate Ca2+-dependent signaling.
    Robinson P, Liu X, Sparrow A, Patel S, Zhang YH, Casadei B, Watkins H, Redwood C.
    J Biol Chem; 2018 Jul 06; 293(27):10487-10499. PubMed ID: 29760186
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  • 2. Dilated cardiomyopathy mutations in thin-filament regulatory proteins reduce contractility, suppress systolic Ca2+, and activate NFAT and Akt signaling.
    Robinson P, Sparrow AJ, Patel S, Malinowska M, Reilly SN, Zhang YH, Casadei B, Watkins H, Redwood C.
    Am J Physiol Heart Circ Physiol; 2020 Aug 01; 319(2):H306-H319. PubMed ID: 32618513
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  • 3. Genotype-Dependent and -Independent Calcium Signaling Dysregulation in Human Hypertrophic Cardiomyopathy.
    Helms AS, Alvarado FJ, Yob J, Tang VT, Pagani F, Russell MW, Valdivia HH, Day SM.
    Circulation; 2016 Nov 29; 134(22):1738-1748. PubMed ID: 27688314
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  • 4. Desensitization of myofilaments to Ca2+ as a therapeutic target for hypertrophic cardiomyopathy with mutations in thin filament proteins.
    Alves ML, Dias FAL, Gaffin RD, Simon JN, Montminy EM, Biesiadecki BJ, Hinken AC, Warren CM, Utter MS, Davis RT, Sakthivel S, Robbins J, Wieczorek DF, Solaro RJ, Wolska BM.
    Circ Cardiovasc Genet; 2014 Apr 29; 7(2):132-143. PubMed ID: 24585742
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  • 5. Mavacamten rescues increased myofilament calcium sensitivity and dysregulation of Ca2+ flux caused by thin filament hypertrophic cardiomyopathy mutations.
    Sparrow AJ, Watkins H, Daniels MJ, Redwood C, Robinson P.
    Am J Physiol Heart Circ Physiol; 2020 Mar 01; 318(3):H715-H722. PubMed ID: 32083971
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  • 6. Pathogenesis of Hypertrophic Cardiomyopathy is Mutation Rather Than Disease Specific: A Comparison of the Cardiac Troponin T E163R and R92Q Mouse Models.
    Ferrantini C, Coppini R, Pioner JM, Gentile F, Tosi B, Mazzoni L, Scellini B, Piroddi N, Laurino A, Santini L, Spinelli V, Sacconi L, De Tombe P, Moore R, Tardiff J, Mugelli A, Olivotto I, Cerbai E, Tesi C, Poggesi C.
    J Am Heart Assoc; 2017 Jul 22; 6(7):. PubMed ID: 28735292
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  • 8. Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations.
    Sparrow AJ, Sievert K, Patel S, Chang YF, Broyles CN, Brook FA, Watkins H, Geeves MA, Redwood CS, Robinson P, Daniels MJ.
    Circ Res; 2019 Apr 12; 124(8):1228-1239. PubMed ID: 30732532
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  • 11. Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca²⁺ sensitivity.
    Memo M, Leung MC, Ward DG, dos Remedios C, Morimoto S, Zhang L, Ravenscroft G, McNamara E, Nowak KJ, Marston SB, Messer AE.
    Cardiovasc Res; 2013 Jul 01; 99(1):65-73. PubMed ID: 23539503
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  • 13. Mutation location of HCM-causing troponin T mutations defines the degree of myofilament dysfunction in human cardiomyocytes.
    Schuldt M, Johnston JR, He H, Huurman R, Pei J, Harakalova M, Poggesi C, Michels M, Kuster DWD, Pinto JR, van der Velden J.
    J Mol Cell Cardiol; 2021 Jan 01; 150():77-90. PubMed ID: 33148509
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  • 14. Hypertrophic cardiomyopathy mutation in cardiac troponin T (R95H) attenuates length-dependent activation in guinea pig cardiac muscle fibers.
    Mickelson AV, Chandra M.
    Am J Physiol Heart Circ Physiol; 2017 Dec 01; 313(6):H1180-H1189. PubMed ID: 28842439
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  • 17. Temporal and mutation-specific alterations in Ca2+ homeostasis differentially determine the progression of cTnT-related cardiomyopathies in murine models.
    Guinto PJ, Haim TE, Dowell-Martino CC, Sibinga N, Tardiff JC.
    Am J Physiol Heart Circ Physiol; 2009 Aug 01; 297(2):H614-26. PubMed ID: 19502551
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