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Journal Abstract Search

359 related items for PubMed ID: 29957526

  • 1. X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
    Yang LL, Wang HL, Zhong L, Yuan C, Liu SY, Yu ZJ, Liu S, Yan YH, Wu C, Wang Y, Wang Z, Yu Y, Chen Q, Li GB.
    Eur J Med Chem; 2018 Jul 15; 155():806-823. PubMed ID: 29957526
    [Abstract] [Full Text] [Related]

  • 2. Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors.
    Yang L, Ma X, Yuan C, He Y, Li L, Fang S, Xia W, He T, Qian S, Xu Z, Li G, Wang Z.
    Eur J Med Chem; 2017 Jul 07; 134():230-241. PubMed ID: 28415012
    [Abstract] [Full Text] [Related]

  • 3. Direct Comparison of SIRT2 Inhibitors: Potency, Specificity, Activity-Dependent Inhibition, and On-Target Anticancer Activities.
    Spiegelman NA, Price IR, Jing H, Wang M, Yang M, Cao J, Hong JY, Zhang X, Aramsangtienchai P, Sadhukhan S, Lin H.
    ChemMedChem; 2018 Sep 19; 13(18):1890-1894. PubMed ID: 30058233
    [Abstract] [Full Text] [Related]

  • 4. Discovery of New SIRT2 Inhibitors by Utilizing a Consensus Docking/Scoring Strategy and Structure-Activity Relationship Analysis.
    Huang S, Song C, Wang X, Zhang G, Wang Y, Jiang X, Sun Q, Huang L, Xiang R, Hu Y, Li L, Yang S.
    J Chem Inf Model; 2017 Apr 24; 57(4):669-679. PubMed ID: 28301150
    [Abstract] [Full Text] [Related]

  • 5. A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer.
    Hoffmann G, Breitenbücher F, Schuler M, Ehrenhofer-Murray AE.
    J Biol Chem; 2014 Feb 21; 289(8):5208-16. PubMed ID: 24379401
    [Abstract] [Full Text] [Related]

  • 6. Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors.
    Khalil NA, Ahmed EM, Zaher AF, El-Zoghbi MS, Sobh EA.
    Eur J Med Chem; 2020 Feb 01; 187():111926. PubMed ID: 31812033
    [Abstract] [Full Text] [Related]

  • 7. Hit-to-lead optimization on aryloxybenzamide derivative virtual screening hit against SIRT.
    Yagci S, Gozelle M, Kaya SG, Ozkan Y, Aksel AB, Bakar-Ates F, Dundar Y, Eren G.
    Bioorg Med Chem; 2021 Jan 15; 30():115961. PubMed ID: 33360574
    [Abstract] [Full Text] [Related]

  • 8. Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition.
    Radwan MO, Ciftci HI, Ali TFS, Koga R, Tateishi H, Nakata A, Ito A, Yoshida M, Fujita M, Otsuka M.
    Bioorg Med Chem Lett; 2020 Oct 01; 30(19):127458. PubMed ID: 32755678
    [Abstract] [Full Text] [Related]

  • 9. Identification of a Selective SIRT2 Inhibitor and Its Anti-breast Cancer Activity.
    Shah AA, Ito A, Nakata A, Yoshida M.
    Biol Pharm Bull; 2016 Oct 01; 39(10):1739-1742. PubMed ID: 27725455
    [Abstract] [Full Text] [Related]

  • 10. A Glycoconjugated SIRT2 Inhibitor with Aqueous Solubility Allows Structure-Based Design of SIRT2 Inhibitors.
    Hong JY, Price IR, Bai JJ, Lin H.
    ACS Chem Biol; 2019 Aug 16; 14(8):1802-1810. PubMed ID: 31373792
    [Abstract] [Full Text] [Related]

  • 11. Pharmacophore modeling and virtual screening studies to identify novel selective SIRT2 inhibitors.
    Eren G, Bruno A, Guntekin-Ergun S, Cetin-Atalay R, Ozgencil F, Ozkan Y, Gozelle M, Kaya SG, Costantino G.
    J Mol Graph Model; 2019 Jun 16; 89():60-73. PubMed ID: 30870650
    [Abstract] [Full Text] [Related]

  • 12. Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines.
    Kozako T, Mellini P, Ohsugi T, Aikawa A, Uchida YI, Honda SI, Suzuki T.
    BMC Cancer; 2018 Aug 06; 18(1):791. PubMed ID: 30081901
    [Abstract] [Full Text] [Related]

  • 13. Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.
    Moniot S, Forgione M, Lucidi A, Hailu GS, Nebbioso A, Carafa V, Baratta F, Altucci L, Giacché N, Passeri D, Pellicciari R, Mai A, Steegborn C, Rotili D.
    J Med Chem; 2017 Mar 23; 60(6):2344-2360. PubMed ID: 28240897
    [Abstract] [Full Text] [Related]

  • 14. Selective SIRT2 inhibitors as promising anticancer therapeutics: An update from 2016 to 2020.
    Roshdy E, Mustafa M, Shaltout AE, Radwan MO, Ibrahim MAA, Soliman ME, Fujita M, Otsuka M, Ali TFS.
    Eur J Med Chem; 2021 Nov 15; 224():113709. PubMed ID: 34303869
    [Abstract] [Full Text] [Related]

  • 15. Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies.
    Chowdhury S, Sripathy S, Webster A, Park A, Lao U, Hsu JH, Loe T, Bedalov A, Simon JA.
    Molecules; 2020 Jan 21; 25(3):. PubMed ID: 31973227
    [Abstract] [Full Text] [Related]

  • 16. New SIRT2 inhibitors: Histidine-based bleomycin spin-off.
    Ali TFS, Ciftci HI, Radwan MO, Koga R, Ohsugi T, Okiyama Y, Honma T, Nakata A, Ito A, Yoshida M, Fujita M, Otsuka M.
    Bioorg Med Chem; 2019 May 01; 27(9):1767-1775. PubMed ID: 30885568
    [Abstract] [Full Text] [Related]

  • 17. Exploring the newer oxadiazoles as real inhibitors of human SIRT2 in hepatocellular cancer cells.
    Dukanya, Shanmugam MK, Rangappa S, Metri PK, Mohan S, Basappa, Rangappa KS.
    Bioorg Med Chem Lett; 2020 Aug 15; 30(16):127330. PubMed ID: 32631535
    [Abstract] [Full Text] [Related]

  • 18. The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.
    Di Fruscia P, Zacharioudakis E, Liu C, Moniot S, Laohasinnarong S, Khongkow M, Harrison IF, Koltsida K, Reynolds CR, Schmidtkunz K, Jung M, Chapman KL, Steegborn C, Dexter DT, Sternberg MJ, Lam EW, Fuchter MJ.
    ChemMedChem; 2015 Jan 15; 10(1):69-82. PubMed ID: 25395356
    [Abstract] [Full Text] [Related]

  • 19. Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach.
    Cui H, Kamal Z, Ai T, Xu Y, More SS, Wilson DJ, Chen L.
    J Med Chem; 2014 Oct 23; 57(20):8340-57. PubMed ID: 25275824
    [Abstract] [Full Text] [Related]

  • 20. Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton.
    Sakai T, Matsumoto Y, Ishikawa M, Sugita K, Hashimoto Y, Wakai N, Kitao A, Morishita E, Toyoshima C, Hayashi T, Akiyama T.
    Bioorg Med Chem; 2015 Jan 15; 23(2):328-39. PubMed ID: 25515955
    [Abstract] [Full Text] [Related]

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