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Journal Abstract Search

1048 related items for PubMed ID: 30081353

  • 1. 1,2,3-triazole tethered Indole-3-glyoxamide derivatives as multiple inhibitors of 5-LOX, COX-2 & tubulin: Their anti-proliferative & anti-inflammatory activity.
    Naaz F, Preeti Pallavi MC, Shafi S, Mulakayala N, Shahar Yar M, Sampath Kumar HM.
    Bioorg Chem; 2018 Dec; 81():1-20. PubMed ID: 30081353
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis, biological evaluation and docking study of novel indole-2-amide as anti-inflammatory agents with dual inhibition of COX and 5-LOX.
    Huang Y, Zhang B, Li J, Liu H, Zhang Y, Yang Z, Liu W.
    Eur J Med Chem; 2019 Oct 15; 180():41-50. PubMed ID: 31299586
    [Abstract] [Full Text] [Related]

  • 3. Synthesis and Preclinical Evaluation of Indole Triazole Conjugates as Microtubule Targeting Agents that are Effective against MCF-7 Breast Cancer Cell Lines.
    Yele V, Pindiprolu SKSS, Sana S, Ramamurty DSVNM, Madasi JRK, Vadlamani S.
    Anticancer Agents Med Chem; 2021 Oct 15; 21(8):1047-1055. PubMed ID: 32981511
    [Abstract] [Full Text] [Related]

  • 4. Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy.
    Cai H, Huang X, Xu S, Shen H, Zhang P, Huang Y, Jiang J, Sun Y, Jiang B, Wu X, Yao H, Xu J.
    Eur J Med Chem; 2016 Jan 27; 108():89-103. PubMed ID: 26638042
    [Abstract] [Full Text] [Related]

  • 5. New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study.
    El-Miligy MMM, Hazzaa AA, El-Messmary H, Nassra RA, El-Hawash SAM.
    Bioorg Chem; 2017 Jun 27; 72():102-115. PubMed ID: 28390993
    [Abstract] [Full Text] [Related]

  • 6. New 1,2,4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studies.
    Fadaly WAA, Elshaier YAMM, Hassanein EHM, Abdellatif KRA.
    Bioorg Chem; 2020 May 27; 98():103752. PubMed ID: 32197148
    [Abstract] [Full Text] [Related]

  • 7. Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study.
    Lamie PF, Ali WAM, Bazgier V, Rárová L.
    Eur J Med Chem; 2016 Nov 10; 123():803-813. PubMed ID: 27541263
    [Abstract] [Full Text] [Related]

  • 8. Synthesis, anti-inflammatory screening, molecular docking, and COX-1,2/-5-LOX inhibition profile of some novel quinoline derivatives.
    Chaaban I, Rizk OH, Ibrahim TM, Henen SS, El-Khawass EM, Bayad AE, El-Ashmawy IM, Nematalla HA.
    Bioorg Chem; 2018 Aug 10; 78():220-235. PubMed ID: 29602046
    [Abstract] [Full Text] [Related]

  • 9. Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids.
    Abdu-Allah HHM, Abdelmoez AAB, Tarazi H, El-Shorbagi AA, El-Awady R.
    Bioorg Chem; 2020 Jan 10; 94():103378. PubMed ID: 31677858
    [Abstract] [Full Text] [Related]

  • 10. Design and synthesis of newer 1,3,4-oxadiazole and 1,2,4-triazole based Topsentin analogues as anti-proliferative agent targeting tubulin.
    Naaz F, Ahmad F, Lone BA, Pokharel YR, Fuloria NK, Fuloria S, Ravichandran M, Pattabhiraman L, Shafi S, Shahar Yar M.
    Bioorg Chem; 2020 Jan 10; 95():103519. PubMed ID: 31884140
    [Abstract] [Full Text] [Related]

  • 11. Pyrazole-hydrazone derivatives as anti-inflammatory agents: Design, synthesis, biological evaluation, COX-1,2/5-LOX inhibition and docking study.
    Abdelgawad MA, Labib MB, Abdel-Latif M.
    Bioorg Chem; 2017 Oct 10; 74():212-220. PubMed ID: 28865292
    [Abstract] [Full Text] [Related]

  • 12. Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases.
    Elzahhar PA, Abd El Wahab SM, Elagawany M, Daabees H, Belal ASF, El-Yazbi AF, Eid AH, Alaaeddine R, Hegazy RR, Allam RM, Helmy MW, Bahaa Elgendy, Angeli A, El-Hawash SA, Supuran CT.
    Eur J Med Chem; 2020 Aug 15; 200():112439. PubMed ID: 32485532
    [Abstract] [Full Text] [Related]

  • 13. Novel N-substituted 5-aminosalicylamides as dual inhibitors of cyclooxygenase and 5-lipoxygenase enzymes: Synthesis, biological evaluation and docking study.
    El-Nagar MKS, Abdu-Allah HHM, Salem OIA, Kafafy AN, Farghaly HSM.
    Bioorg Chem; 2018 Aug 15; 78():80-93. PubMed ID: 29550533
    [Abstract] [Full Text] [Related]

  • 14. Design, synthesis, and biological evaluation of novel 1,2-diaryl-4-substituted-benzylidene-5(4H)-imidazolone derivatives as cytotoxic agents and COX-2/LOX inhibitors.
    Lamie PF, Philoppes JN, Rárová L.
    Arch Pharm (Weinheim); 2018 Apr 15; 351(3-4):e1700311. PubMed ID: 29400411
    [Abstract] [Full Text] [Related]

  • 15. Discovery of potential anti-inflammatory drugs: diaryl-1,2,4-triazoles bearing N-hydroxyurea moiety as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase.
    Jiang B, Huang X, Yao H, Jiang J, Wu X, Jiang S, Wang Q, Lu T, Xu J.
    Org Biomol Chem; 2014 Apr 07; 12(13):2114-27. PubMed ID: 24562695
    [Abstract] [Full Text] [Related]

  • 16. Discovery of small molecule acting as multitarget inhibitor of colorectal cancer by simultaneous blocking of the key COX-2, 5-LOX and PIM-1 kinase enzymes.
    El-Miligy MMM, Al-Kubeisi AK, El-Zemity SR, Nassra RA, Abu-Serie MM, Hazzaa AA.
    Bioorg Chem; 2021 Oct 07; 115():105171. PubMed ID: 34303896
    [Abstract] [Full Text] [Related]

  • 17. Novel click modifiable thioquinazolinones as anti-inflammatory agents: Design, synthesis, biological evaluation and docking study.
    Moussa G, Alaaeddine R, Alaeddine LM, Nassra R, Belal ASF, Ismail A, El-Yazbi AF, Abdel-Ghany YS, Hazzaa A.
    Eur J Med Chem; 2018 Jan 20; 144():635-650. PubMed ID: 29289887
    [Abstract] [Full Text] [Related]

  • 18. Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents.
    Jan MS, Ahmad S, Hussain F, Ahmad A, Mahmood F, Rashid U, Abid OU, Ullah F, Ayaz M, Sadiq A.
    Eur J Med Chem; 2020 Jan 15; 186():111863. PubMed ID: 31740050
    [Abstract] [Full Text] [Related]

  • 19. Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities.
    Ghatak S, Vyas A, Misra S, O'Brien P, Zambre A, Fresco VM, Markwald RR, Swamy KV, Afrasiabi Z, Choudhury A, Khetmalas M, Padhye S.
    Bioorg Med Chem Lett; 2014 Jan 01; 24(1):317-24. PubMed ID: 24295787
    [Abstract] [Full Text] [Related]

  • 20. Design, synthesis and evaluation of novel diaryl-1,5-diazoles derivatives bearing morpholine as potent dual COX-2/5-LOX inhibitors and antitumor agents.
    Li Z, Wang ZC, Li X, Abbas M, Wu SY, Ren SZ, Liu QX, Liu Y, Chen PW, Duan YT, Lv PC, Zhu HL.
    Eur J Med Chem; 2019 May 01; 169():168-184. PubMed ID: 30877972
    [Abstract] [Full Text] [Related]

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