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Journal Abstract Search

464 related items for PubMed ID: 30117728

  • 1. Targeted Structure-Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc1 and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis.
    McConnell EV, Bruzual I, Pou S, Winter R, Dodean RA, Smilkstein MJ, Krollenbrock A, Nilsen A, Zakharov LN, Riscoe MK, Doggett JS.
    ACS Infect Dis; 2018 Nov 09; 4(11):1574-1584. PubMed ID: 30117728
    [Abstract] [Full Text] [Related]

  • 2. Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum.
    Stickles AM, de Almeida MJ, Morrisey JM, Sheridan KA, Forquer IP, Nilsen A, Winter RW, Burrows JN, Fidock DA, Vaidya AB, Riscoe MK.
    Antimicrob Agents Chemother; 2015 Apr 09; 59(4):1977-82. PubMed ID: 25605352
    [Abstract] [Full Text] [Related]

  • 3. Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria.
    Stickles AM, Smilkstein MJ, Morrisey JM, Li Y, Forquer IP, Kelly JX, Pou S, Winter RW, Nilsen A, Vaidya AB, Riscoe MK.
    Antimicrob Agents Chemother; 2016 Aug 09; 60(8):4853-9. PubMed ID: 27270285
    [Abstract] [Full Text] [Related]

  • 4. Genetic Evidence for Cytochrome b Qi Site Inhibition by 4(1H)-Quinolone-3-Diarylethers and Antimycin in Toxoplasma gondii.
    Alday PH, Bruzual I, Nilsen A, Pou S, Winter R, Ben Mamoun C, Riscoe MK, Doggett JS.
    Antimicrob Agents Chemother; 2017 Feb 09; 61(2):. PubMed ID: 27919897
    [Abstract] [Full Text] [Related]

  • 5. Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis.
    Doggett JS, Nilsen A, Forquer I, Wegmann KW, Jones-Brando L, Yolken RH, Bordón C, Charman SA, Katneni K, Schultz T, Burrows JN, Hinrichs DJ, Meunier B, Carruthers VB, Riscoe MK.
    Proc Natl Acad Sci U S A; 2012 Sep 25; 109(39):15936-41. PubMed ID: 23019377
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  • 6. Growth inhibition of Toxoplasma gondii and Plasmodium falciparum by nanomolar concentrations of 1-hydroxy-2-dodecyl-4(1H)quinolone, a high-affinity inhibitor of alternative (type II) NADH dehydrogenases.
    Saleh A, Friesen J, Baumeister S, Gross U, Bohne W.
    Antimicrob Agents Chemother; 2007 Apr 25; 51(4):1217-22. PubMed ID: 17242151
    [Abstract] [Full Text] [Related]

  • 7. Structure-activity relationships of Toxoplasma gondii cytochrome bc1 inhibitors.
    Alday PH, Nilsen A, Doggett JS.
    Expert Opin Drug Discov; 2022 Sep 25; 17(9):997-1011. PubMed ID: 35772172
    [Abstract] [Full Text] [Related]

  • 8. The antimalarial compound ELQ-400 is an unusual inhibitor of the bc1 complex, targeting both Qo and Qi sites.
    Song Z, Iorga BI, Mounkoro P, Fisher N, Meunier B.
    FEBS Lett; 2018 Apr 25; 592(8):1346-1356. PubMed ID: 29574797
    [Abstract] [Full Text] [Related]

  • 9. New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections.
    McPhillie M, Zhou Y, El Bissati K, Dubey J, Lorenzi H, Capper M, Lukens AK, Hickman M, Muench S, Verma SK, Weber CR, Wheeler K, Gordon J, Sanders J, Moulton H, Wang K, Kim TK, He Y, Santos T, Woods S, Lee P, Donkin D, Kim E, Fraczek L, Lykins J, Esaa F, Alibana-Clouser F, Dovgin S, Weiss L, Brasseur G, Wirth D, Kent M, Hood L, Meunieur B, Roberts CW, Hasnain SS, Antonyuk SV, Fishwick C, McLeod R.
    Sci Rep; 2016 Jul 14; 6():29179. PubMed ID: 27412848
    [Abstract] [Full Text] [Related]

  • 10. Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy.
    Stickles AM, Ting LM, Morrisey JM, Li Y, Mather MW, Meermeier E, Pershing AM, Forquer IP, Miley GP, Pou S, Winter RW, Hinrichs DJ, Kelly JX, Kim K, Vaidya AB, Riscoe MK, Nilsen A.
    Am J Trop Med Hyg; 2015 Jun 14; 92(6):1195-201. PubMed ID: 25918204
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  • 13. Orally Bioavailable Endochin-Like Quinolone Carbonate Ester Prodrug Reduces Toxoplasma gondii Brain Cysts.
    Doggett JS, Schultz T, Miller AJ, Bruzual I, Pou S, Winter R, Dodean R, Zakharov LN, Nilsen A, Riscoe MK, Carruthers VB.
    Antimicrob Agents Chemother; 2020 Aug 20; 64(9):. PubMed ID: 32540978
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  • 19. Targeted Phenotypic Screening in Plasmodium falciparum and Toxoplasma gondii Reveals Novel Modes of Action of Medicines for Malaria Venture Malaria Box Molecules.
    Subramanian G, Belekar MA, Shukla A, Tong JX, Sinha A, Chu TTT, Kulkarni AS, Preiser PR, Reddy DS, Tan KSW, Shanmugam D, Chandramohanadas R.
    mSphere; 2018 Aug 20; 3(1):. PubMed ID: 29359192
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