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152 related items for PubMed ID: 30143707

  • 1. Mapping discontinuous epitopes for MRK-16, UIC2 and 4E3 antibodies to extracellular loops 1 and 4 of human P-glycoprotein.
    Vahedi S, Lusvarghi S, Pluchino K, Shafrir Y, Durell SR, Gottesman MM, Ambudkar SV.
    Sci Rep; 2018 Aug 24; 8(1):12716. PubMed ID: 30143707
    [Abstract] [Full Text] [Related]

  • 2. The extracellular loop between TM5 and TM6 of P-glycoprotein is required for reactivity with monoclonal antibody UIC2.
    Zhou Y, Gottesman MM, Pastan I.
    Arch Biochem Biophys; 1999 Jul 01; 367(1):74-80. PubMed ID: 10375401
    [Abstract] [Full Text] [Related]

  • 3. Topology of P-glycoprotein as determined by epitope mapping of MRK-16 monoclonal antibody.
    Georges E, Tsuruo T, Ling V.
    J Biol Chem; 1993 Jan 25; 268(3):1792-8. PubMed ID: 7678410
    [Abstract] [Full Text] [Related]

  • 4. Use of a peptide mimotope to guide the humanization of MRK-16, an anti-P-glycoprotein monoclonal antibody.
    Tang Y, Beuerlein G, Pecht G, Chilton T, Huse WD, Watkins JD.
    J Biol Chem; 1999 Sep 24; 274(39):27371-8. PubMed ID: 10488067
    [Abstract] [Full Text] [Related]

  • 5. Mode of binding of anti-P-glycoprotein antibody MRK-16 to its antigen. A crystallographic and molecular modeling study.
    Vasudevan S, Tsuruo T, Rose DR.
    J Biol Chem; 1998 Sep 25; 273(39):25413-9. PubMed ID: 9738009
    [Abstract] [Full Text] [Related]

  • 6. Crystal structure of the antigen-binding fragment of a monoclonal antibody specific for the multidrug-resistance-linked ABC transporter human P-glycoprotein.
    Esser L, Shukla S, Zhou F, Ambudkar SV, Xia D.
    Acta Crystallogr F Struct Biol Commun; 2016 Aug 25; 72(Pt 8):636-41. PubMed ID: 27487928
    [Abstract] [Full Text] [Related]

  • 7. Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1).
    Sajid A, Lusvarghi S, Chufan EE, Ambudkar SV.
    PLoS One; 2018 Aug 25; 13(9):e0204693. PubMed ID: 30265721
    [Abstract] [Full Text] [Related]

  • 8. Conformational heterogeneity of P-glycoprotein.
    Goda K, Nagy H, Bene L, Balázs M, Arceci R, Mechetner E, Szabó G.
    Cancer Detect Prev; 2000 Aug 25; 24(5):415-21. PubMed ID: 11129983
    [Abstract] [Full Text] [Related]

  • 9. Binding properties of monoclonal antibodies recognizing external epitopes of the human MDR1 P-glycoprotein.
    Schinkel AH, Arceci RJ, Smit JJ, Wagenaar E, Baas F, Dollé M, Tsuruo T, Mechetner EB, Roninson IB, Borst P.
    Int J Cancer; 1993 Sep 30; 55(3):478-84. PubMed ID: 8104165
    [Abstract] [Full Text] [Related]

  • 10. Functional characterization of glycosylation-deficient human P-glycoprotein using a vaccinia virus expression system.
    Gribar JJ, Ramachandra M, Hrycyna CA, Dey S, Ambudkar SV.
    J Membr Biol; 2000 Feb 01; 173(3):203-14. PubMed ID: 10667916
    [Abstract] [Full Text] [Related]

  • 11. Human-Mouse Chimeras with Normal Expression and Function Reveal That Major Domain Swapping Is Tolerated by P-Glycoprotein (ABCB1).
    Pluchino KM, Hall MD, Moen JK, Chufan EE, Fetsch PA, Shukla S, Gill DR, Hyde SC, Xia D, Ambudkar SV, Gottesman MM.
    Biochemistry; 2016 Feb 23; 55(7):1010-23. PubMed ID: 26820614
    [Abstract] [Full Text] [Related]

  • 12. Combined therapy with anti-P-glycoprotein antibody and macrophage colony-stimulating factor gene transduction for multiorgan metastases of multidrug-resistant human small cell lung cancer in NK cell-depleted SCID mice.
    Yano S, Hanibuchi M, Nishioka Y, Nokihara H, Nishimura N, Tsuruo T, Sone S.
    Int J Cancer; 1999 Jul 02; 82(1):105-11. PubMed ID: 10360828
    [Abstract] [Full Text] [Related]

  • 13. Global alteration of the drug-binding pocket of human P-glycoprotein (ABCB1) by substitution of fifteen conserved residues reveals a negative correlation between substrate size and transport efficiency.
    Vahedi S, Chufan EE, Ambudkar SV.
    Biochem Pharmacol; 2017 Nov 01; 143():53-64. PubMed ID: 28728917
    [Abstract] [Full Text] [Related]

  • 14. Possibility of the reversal of multidrug resistance and the avoidance of side effects by liposomes modified with MRK-16, a monoclonal antibody to P-glycoprotein.
    Matsuo H, Wakasugi M, Takanaga H, Ohtani H, Naito M, Tsuruo T, Sawada Y.
    J Control Release; 2001 Nov 09; 77(1-2):77-86. PubMed ID: 11689261
    [Abstract] [Full Text] [Related]

  • 15. Monoclonal antibody to an external epitope of the human mdr1 P-glycoprotein.
    Arceci RJ, Stieglitz K, Bras J, Schinkel A, Baas F, Croop J.
    Cancer Res; 1993 Jan 15; 53(2):310-7. PubMed ID: 7678072
    [Abstract] [Full Text] [Related]

  • 16. Drug-protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoprotein.
    Chufan EE, Kapoor K, Ambudkar SV.
    Biochem Pharmacol; 2016 Feb 01; 101():40-53. PubMed ID: 26686578
    [Abstract] [Full Text] [Related]

  • 17. Cholesterol-dependent conformational changes of P-glycoprotein are detected by the 15D3 monoclonal antibody.
    Gutay-Tóth Z, Fenyvesi F, Bársony O, Szente L, Goda K, Szabó G, Bacsó Z.
    Biochim Biophys Acta; 2016 Mar 01; 1861(3):188-95. PubMed ID: 26704667
    [Abstract] [Full Text] [Related]

  • 18. Reversal of drug resistance in a human colon cancer xenograft expressing MDR1 complementary DNA by in vivo administration of MRK-16 monoclonal antibody.
    Pearson JW, Fogler WE, Volker K, Usui N, Goldenberg SK, Gruys E, Riggs CW, Komschlies K, Wiltrout RH, Tsuruo T.
    J Natl Cancer Inst; 1991 Oct 02; 83(19):1386-91. PubMed ID: 1681110
    [Abstract] [Full Text] [Related]

  • 19. In vivo imaging and specific targeting of P-glycoprotein expression in multidrug resistant nude mice xenografts with [125I]MRK-16 monoclonal antibody.
    Scott AM, Rosa E, Mehta BM, Divgi CR, Finn RD, Biedler JL, Tsuruo T, Kalaigian H, Larson SM.
    Nucl Med Biol; 1995 May 02; 22(4):497-504. PubMed ID: 7550027
    [Abstract] [Full Text] [Related]

  • 20. P-glycoprotein-mediated colchicine resistance in different cell lines correlates with the effects of colchicine on P-glycoprotein conformation.
    Druley TE, Stein WD, Ruth A, Roninson IB.
    Biochemistry; 2001 Apr 10; 40(14):4323-31. PubMed ID: 11284688
    [Abstract] [Full Text] [Related]

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