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Journal Abstract Search

286 related items for PubMed ID: 30212196

  • 1. Two Decades under the Influence of the Rule of Five and the Changing Properties of Approved Oral Drugs.
    Shultz MD.
    J Med Chem; 2019 Feb 28; 62(4):1701-1714. PubMed ID: 30212196
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  • 2. Molecular inflation, attrition and the rule of five.
    Leeson PD.
    Adv Drug Deliv Rev; 2016 Jun 01; 101():22-33. PubMed ID: 26836397
    [Abstract] [Full Text] [Related]

  • 3. Oral druggable space beyond the rule of 5: insights from drugs and clinical candidates.
    Doak BC, Over B, Giordanetto F, Kihlberg J.
    Chem Biol; 2014 Sep 18; 21(9):1115-42. PubMed ID: 25237858
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  • 5. Trends in oral small-molecule drug discovery and product development based on product launches before and after the Rule of Five.
    Stegemann S, Moreton C, Svanbäck S, Box K, Motte G, Paudel A.
    Drug Discov Today; 2023 Feb 18; 28(2):103344. PubMed ID: 36442594
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  • 6. Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions.
    Lipinski CA.
    Adv Drug Deliv Rev; 2016 Jun 01; 101():34-41. PubMed ID: 27154268
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  • 7. The evolution of synthetic oral drug properties.
    Proudfoot JR.
    Bioorg Med Chem Lett; 2005 Feb 15; 15(4):1087-90. PubMed ID: 15686918
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  • 8. Facts, Patterns, and Principles in Drug Discovery: Appraising the Rule of 5 with Measured Physicochemical Data.
    Tinworth CP, Young RJ.
    J Med Chem; 2020 Sep 24; 63(18):10091-10108. PubMed ID: 32324397
    [Abstract] [Full Text] [Related]

  • 9. Property distribution of drug-related chemical databases.
    Oprea TI.
    J Comput Aided Mol Des; 2000 Mar 24; 14(3):251-64. PubMed ID: 10756480
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  • 15. Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety.
    Meanwell NA.
    Chem Res Toxicol; 2011 Sep 19; 24(9):1420-56. PubMed ID: 21790149
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  • 16. Improving Drug Design: An Update on Recent Applications of Efficiency Metrics, Strategies for Replacing Problematic Elements, and Compounds in Nontraditional Drug Space.
    Meanwell NA.
    Chem Res Toxicol; 2016 Apr 18; 29(4):564-616. PubMed ID: 26974882
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  • 17. The influence of drug-like concepts on decision-making in medicinal chemistry.
    Leeson PD, Springthorpe B.
    Nat Rev Drug Discov; 2007 Nov 18; 6(11):881-90. PubMed ID: 17971784
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  • 18. The impact of physicochemical and molecular properties in drug design: navigation in the "drug-like" chemical space.
    Vallianatou T, Giaginis C, Tsantili-Kakoulidou A.
    Adv Exp Med Biol; 2015 Nov 18; 822():187-94. PubMed ID: 25416989
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  • 19. Absorption matters: A closer look at popular oral bioavailability rules for drug approvals.
    Caminero Gomes Soares A, Marques Sousa GH, Calil RL, Goulart Trossini GH.
    Mol Inform; 2023 Nov 18; 42(11):e202300115. PubMed ID: 37550251
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