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Journal Abstract Search

269 related items for PubMed ID: 30222362

  • 1. Evaluating the Utility of Canine Mdr1 Knockout Madin-Darby Canine Kidney I Cells in Permeability Screening and Efflux Substrate Determination.
    Chen EC, Broccatelli F, Plise E, Chen B, Liu L, Cheong J, Zhang S, Jorski J, Gaffney K, Umemoto KK, Salphati L.
    Mol Pharm; 2018 Nov 05; 15(11):5103-5113. PubMed ID: 30222362
    [Abstract] [Full Text] [Related]

  • 2. Characterization and Validation of Canine P-Glycoprotein-Deficient MDCK II Cell Lines for Efflux Substrate Screening.
    Ye D, Harder A, Fang Z, Weinheimer M, Laplanche L, Mezler M.
    Pharm Res; 2020 Sep 11; 37(10):194. PubMed ID: 32918191
    [Abstract] [Full Text] [Related]

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  • 4. A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.
    Karlgren M, Simoff I, Backlund M, Wegler C, Keiser M, Handin N, Müller J, Lundquist P, Jareborg AC, Oswald S, Artursson P.
    J Pharm Sci; 2017 Sep 11; 106(9):2909-2913. PubMed ID: 28450237
    [Abstract] [Full Text] [Related]

  • 5. Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1.
    Wegler C, Gazit M, Issa K, Subramaniam S, Artursson P, Karlgren M.
    J Pharm Sci; 2021 Jan 11; 110(1):388-396. PubMed ID: 33007277
    [Abstract] [Full Text] [Related]

  • 6. Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9.
    Simoff I, Karlgren M, Backlund M, Lindström AC, Gaugaz FZ, Matsson P, Artursson P.
    J Pharm Sci; 2016 Feb 11; 105(2):1017-1021. PubMed ID: 26869442
    [Abstract] [Full Text] [Related]

  • 7. Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of the coumarinic acid-based cyclic prodrug of the opioid peptide DADLE.
    Tang F, Borchardt RT.
    Pharm Res; 2002 Jun 11; 19(6):787-93. PubMed ID: 12134948
    [Abstract] [Full Text] [Related]

  • 8. Isolation of MDCK cells with low expression of mdr1 gene and their use in membrane permeability screening.
    Bokulić A, Padovan J, Stupin-Polančec D, Milić A.
    Acta Pharm; 2022 Jun 01; 72(2):275-288. PubMed ID: 36651516
    [Abstract] [Full Text] [Related]

  • 9. Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT).
    Guo A, Marinaro W, Hu P, Sinko PJ.
    Drug Metab Dispos; 2002 Apr 01; 30(4):457-63. PubMed ID: 11901101
    [Abstract] [Full Text] [Related]

  • 10. Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?
    Tang F, Horie K, Borchardt RT.
    Pharm Res; 2002 Jun 01; 19(6):765-72. PubMed ID: 12134945
    [Abstract] [Full Text] [Related]

  • 11. Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of an acyloxyalkoxy-based cyclic prodrug of the opioid peptide DADLE.
    Tang F, Borchardt RT.
    Pharm Res; 2002 Jun 01; 19(6):780-6. PubMed ID: 12134947
    [Abstract] [Full Text] [Related]

  • 12. Evaluation of P-glycoprotein-mediated renal drug interactions in an MDR1-MDCK model.
    Karyekar CS, Eddington ND, Garimella TS, Gubbins PO, Dowling TC.
    Pharmacotherapy; 2003 Apr 01; 23(4):436-42. PubMed ID: 12680473
    [Abstract] [Full Text] [Related]

  • 13. Utilizing a Dual Human Transporter MDCKII-MDR1-BCRP Cell Line to Assess Efflux at the Blood Brain Barrier.
    Colclough N, Alluri RV, Tucker JW, Gozalpour E, Li D, Du H, Li W, Harlfinger S, O'Neill DJ, Sproat GG, Chen K, Yan Y, McGinnity DF.
    Drug Metab Dispos; 2024 Jan 09; 52(2):95-105. PubMed ID: 38071533
    [Abstract] [Full Text] [Related]

  • 14. Investigation of MDR1-overexpressing cell lines to derive a quantitative prediction approach for brain disposition using in vitro efflux activities.
    Sato S, Tohyama K, Kosugi Y.
    Eur J Pharm Sci; 2020 Jan 15; 142():105119. PubMed ID: 31682973
    [Abstract] [Full Text] [Related]

  • 15. Evaluation of Drug Transport in MDCKII-Wild Type, MDCKII-MDR1, MDCKII-BCRP and Caco-2 Cell Lines.
    Mukkavilli R, Jadhav G, Vangala S.
    Curr Pharm Biotechnol; 2017 Jan 15; 18(14):1151-1158. PubMed ID: 29521222
    [Abstract] [Full Text] [Related]

  • 16. Validation of Human MDR1-MDCK and BCRP-MDCK Cell Lines to Improve the Prediction of Brain Penetration.
    Feng B, West M, Patel NC, Wager T, Hou X, Johnson J, Tremaine L, Liras J.
    J Pharm Sci; 2019 Jul 15; 108(7):2476-2483. PubMed ID: 30794795
    [Abstract] [Full Text] [Related]

  • 17. Comparison of MDCK-MDR1 and Caco-2 cell based permeability assays for anti-malarial drug screening and drug investigations.
    Jin X, Luong TL, Reese N, Gaona H, Collazo-Velez V, Vuong C, Potter B, Sousa JC, Olmeda R, Li Q, Xie L, Zhang J, Zhang P, Reichard G, Melendez V, Marcsisin SR, Pybus BS.
    J Pharmacol Toxicol Methods; 2014 Jul 15; 70(2):188-94. PubMed ID: 25150934
    [Abstract] [Full Text] [Related]

  • 18. Transfected MDCK cell line with enhanced expression of CYP3A4 and P-glycoprotein as a model to study their role in drug transport and metabolism.
    Kwatra D, Budda B, Vadlapudi AD, Vadlapatla RK, Pal D, Mitra AK.
    Mol Pharm; 2012 Jul 02; 9(7):1877-86. PubMed ID: 22676443
    [Abstract] [Full Text] [Related]

  • 19. Functional assessment of multiple P-glycoprotein (P-gp) probe substrates: influence of cell line and modulator concentration on P-gp activity.
    Taub ME, Podila L, Ely D, Almeida I.
    Drug Metab Dispos; 2005 Nov 02; 33(11):1679-87. PubMed ID: 16093365
    [Abstract] [Full Text] [Related]

  • 20. Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice.
    Ozgür B, Saaby L, Janfelt C, Langthaler K, Eneberg E, Jacobsen AM, Badolo L, Montanari D, Brodin B.
    Eur J Pharm Biopharm; 2021 Dec 02; 169():211-219. PubMed ID: 34756975
    [Abstract] [Full Text] [Related]

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