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Journal Abstract Search

183 related items for PubMed ID: 30243240

  • 1. Identification of human, rat and mouse hydrolyzing enzymes bioconverting amino acid ester prodrug of ketoprofen.
    Huttunen KM.
    Bioorg Chem; 2018 Dec; 81():494-503. PubMed ID: 30243240
    [Abstract] [Full Text] [Related]

  • 2. L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery.
    Puris E, Gynther M, Huttunen J, Auriola S, Huttunen KM.
    Eur J Pharm Sci; 2019 Mar 01; 129():99-109. PubMed ID: 30625368
    [Abstract] [Full Text] [Related]

  • 3. L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs.
    Puris E, Gynther M, Huttunen J, Petsalo A, Huttunen KM.
    J Control Release; 2017 Sep 10; 261():93-104. PubMed ID: 28662899
    [Abstract] [Full Text] [Related]

  • 4. Aminopeptidase B can bioconvert L-type amino acid transporter 1 (LAT1)-utilizing amide prodrugs in the brain.
    Hugele A, Löffler S, Molina BH, Guillon M, Montaser AB, Auriola S, Huttunen KM.
    Front Pharmacol; 2022 Sep 10; 13():1034964. PubMed ID: 36339537
    [Abstract] [Full Text] [Related]

  • 5. Identification of carboxylesterases expressed in rat intestine and effects of their hydrolyzing activity in predicting first-pass metabolism of ester prodrugs.
    Liu D, Gao J, Zhang C, Ren X, Liu Y, Xu Y.
    Pharmazie; 2011 Nov 10; 66(11):888-93. PubMed ID: 22204136
    [Abstract] [Full Text] [Related]

  • 6. Mechanistic Study on the Use of the l-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets.
    Puris E, Gynther M, de Lange ECM, Auriola S, Hammarlund-Udenaes M, Huttunen KM, Loryan I.
    Mol Pharm; 2019 Jul 01; 16(7):3261-3274. PubMed ID: 31180686
    [Abstract] [Full Text] [Related]

  • 7. Biotransformation Capacity of Carboxylesterase in Skin and Keratinocytes for the Penta-Ethyl Ester Prodrug of DTPA.
    Fu J, Sadgrove M, Marson L, Jay M.
    Drug Metab Dispos; 2016 Aug 01; 44(8):1313-8. PubMed ID: 27130352
    [Abstract] [Full Text] [Related]

  • 8. Nucleoside ester prodrug substrate specificity of liver carboxylesterase.
    Landowski CP, Lorenzi PL, Song X, Amidon GL.
    J Pharmacol Exp Ther; 2006 Feb 01; 316(2):572-80. PubMed ID: 16223870
    [Abstract] [Full Text] [Related]

  • 9. Interspecies Differences in the Metabolism of a Multiester Prodrug by Carboxylesterases.
    Fu J, Pacyniak E, Leed MGD, Sadgrove MP, Marson L, Jay M.
    J Pharm Sci; 2016 Feb 01; 105(2):989-995. PubMed ID: 26344572
    [Abstract] [Full Text] [Related]

  • 10. [Stereoselectivity of skin carboxylesterase metabolism].
    Zhu QG, Hu JH, Zeng HW.
    Yao Xue Xue Bao; 2005 Apr 01; 40(4):322-6. PubMed ID: 16011259
    [Abstract] [Full Text] [Related]

  • 11. Hepatic, intestinal, renal, and plasma hydrolysis of prodrugs in human, cynomolgus monkey, dog, and rat: implications for in vitro-in vivo extrapolation of clearance of prodrugs.
    Nishimuta H, Houston JB, Galetin A.
    Drug Metab Dispos; 2014 Sep 01; 42(9):1522-31. PubMed ID: 24994071
    [Abstract] [Full Text] [Related]

  • 12. Identification of carboxylesterase-dependent dabigatran etexilate hydrolysis.
    Laizure SC, Parker RB, Herring VL, Hu ZY.
    Drug Metab Dispos; 2014 Feb 01; 42(2):201-6. PubMed ID: 24212379
    [Abstract] [Full Text] [Related]

  • 13. [Hydrolysis by carboxylesterase and disposition of prodrug with ester moiety].
    Imai T.
    Yakugaku Zasshi; 2007 Apr 01; 127(4):611-9. PubMed ID: 17409690
    [Abstract] [Full Text] [Related]

  • 14. Stability of oxymethyl-modified coumarinic acid cyclic prodrugs of diastereomeric opioid peptides in biological media from various animal species including human.
    Liederer BM, Borchardt RT.
    J Pharm Sci; 2005 Oct 01; 94(10):2198-206. PubMed ID: 16136552
    [Abstract] [Full Text] [Related]

  • 15. Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine.
    Saboulard D, Naesens L, Cahard D, Salgado A, Pathirana R, Velazquez S, McGuigan C, De Clercq E, Balzarini J.
    Mol Pharmacol; 1999 Oct 01; 56(4):693-704. PubMed ID: 10496951
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases.
    Mizoi K, Takahashi M, Haba M, Hosokawa M.
    Bioorg Med Chem Lett; 2016 Feb 01; 26(3):921-923. PubMed ID: 26750256
    [Abstract] [Full Text] [Related]

  • 17. L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood-Brain Barrier and into Human and Mouse Brain Parenchymal Cells.
    Montaser AB, Järvinen J, Löffler S, Huttunen J, Auriola S, Lehtonen M, Jalkanen A, Huttunen KM.
    ACS Chem Neurosci; 2020 Dec 16; 11(24):4301-4315. PubMed ID: 33228353
    [Abstract] [Full Text] [Related]

  • 18. Substrate-Competitive Activity-Based Profiling of Ester Prodrug Activating Enzymes.
    Xu H, Majmudar JD, Davda D, Ghanakota P, Kim KH, Carlson HA, Showalter HD, Martin BR, Amidon GL.
    Mol Pharm; 2015 Sep 08; 12(9):3399-407. PubMed ID: 26262434
    [Abstract] [Full Text] [Related]

  • 19. Preclinical Metabolism and Disposition of TP0473292, a Novel Oral Prodrug of the Potent Metabotropic Glutamate 2/3 Receptor Antagonist TP0178894 for the Treatment of Depression.
    Inatani S, Ochi M, Kinoshita K, Yamaguchi JI, Endo H.
    Drug Metab Dispos; 2023 May 08; 51(5):572-582. PubMed ID: 36754836
    [Abstract] [Full Text] [Related]

  • 20. In vitro and in vivo evaluation of the metabolism and bioavailability of ester prodrugs of mgs0039 (3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid), a potent metabotropic glutamate receptor antagonist.
    Nakamura M, Kawakita Y, Yasuhara A, Fukasawa Y, Yoshida K, Sakagami K, Nakazato A.
    Drug Metab Dispos; 2006 Mar 08; 34(3):369-74. PubMed ID: 16326817
    [Abstract] [Full Text] [Related]

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