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Journal Abstract Search

459 related items for PubMed ID: 30337688

  • 1.
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  • 2. AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy.
    Astle MV, Hannan KM, Ng PY, Lee RS, George AJ, Hsu AK, Haupt Y, Hannan RD, Pearson RB.
    Oncogene; 2012 Apr 12; 31(15):1949-62. PubMed ID: 21909130
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  • 3. Discrete signaling mechanisms of mTORC1 and mTORC2: Connected yet apart in cellular and molecular aspects.
    Jhanwar-Uniyal M, Amin AG, Cooper JB, Das K, Schmidt MH, Murali R.
    Adv Biol Regul; 2017 May 12; 64():39-48. PubMed ID: 28189457
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  • 5. Fisetin-induced PTEN expression reverses cellular senescence by inhibiting the mTORC2-Akt Ser473 phosphorylation pathway in vascular smooth muscle cells.
    Kim SG, Sung JY, Kim JR, Choi HC.
    Exp Gerontol; 2021 Dec 12; 156():111598. PubMed ID: 34695518
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  • 8. PI3K/mTOR signaling regulates prostatic branching morphogenesis.
    Ghosh S, Lau H, Simons BW, Powell JD, Meyers DJ, De Marzo AM, Berman DM, Lotan TL.
    Dev Biol; 2011 Dec 15; 360(2):329-42. PubMed ID: 22015718
    [Abstract] [Full Text] [Related]

  • 9. Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways.
    Huang WR, Chiu HC, Liao TL, Chuang KP, Shih WL, Liu HJ.
    PLoS One; 2015 Dec 15; 10(8):e0133699. PubMed ID: 26244501
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  • 10. Cooperation between p21 and Akt is required for p53-dependent cellular senescence.
    Kim YY, Jee HJ, Um JH, Kim YM, Bae SS, Yun J.
    Aging Cell; 2017 Oct 15; 16(5):1094-1103. PubMed ID: 28691365
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  • 11. MicroRNA501-5p induces p53 proteasome degradation through the activation of the mTOR/MDM2 pathway in ADPKD cells.
    de Stephanis L, Mangolini A, Servello M, Harris PC, Dell'Atti L, Pinton P, Aguiari G.
    J Cell Physiol; 2018 Sep 15; 233(9):6911-6924. PubMed ID: 29323708
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  • 12. RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes.
    Weinberg MA.
    Anticancer Drugs; 2016 Jul 15; 27(6):475-87. PubMed ID: 26918392
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  • 13. PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo.
    Parisotto M, Grelet E, El Bizri R, Dai Y, Terzic J, Eckert D, Gargowitsch L, Bornert JM, Metzger D.
    J Exp Med; 2018 Jun 04; 215(6):1749-1763. PubMed ID: 29743291
    [Abstract] [Full Text] [Related]

  • 14. The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt.
    Tooley AS, Kazyken D, Bodur C, Gonzalez IE, Fingar DC.
    J Biol Chem; 2021 Aug 04; 297(2):100942. PubMed ID: 34245780
    [Abstract] [Full Text] [Related]

  • 15. Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth.
    Wang L, Xiong H, Wu F, Zhang Y, Wang J, Zhao L, Guo X, Chang LJ, Zhang Y, You MJ, Koochekpour S, Saleem M, Huang H, Lu J, Deng Y.
    Cell Rep; 2014 Sep 11; 8(5):1461-74. PubMed ID: 25176644
    [Abstract] [Full Text] [Related]

  • 16. Mammalian target of rapamycin is a therapeutic target for murine ovarian endometrioid adenocarcinomas with dysregulated Wnt/β-catenin and PTEN.
    Tanwar PS, Zhang L, Kaneko-Tarui T, Curley MD, Taketo MM, Rani P, Roberts DJ, Teixeira JM.
    PLoS One; 2011 Sep 11; 6(6):e20715. PubMed ID: 21695255
    [Abstract] [Full Text] [Related]

  • 17. Keratoacanthoma of the Lip: Activation of the mTOR Pathway, Tumor Suppressor Proteins, and Tumor Senescence.
    Dillenburg CS, Martins MD, Meurer L, Castilho RM, Squarize CH.
    Medicine (Baltimore); 2015 Sep 11; 94(38):e1552. PubMed ID: 26402814
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  • 18. The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
    Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
    Cancer Res; 2007 Apr 01; 67(7):3043-53. PubMed ID: 17409411
    [Abstract] [Full Text] [Related]

  • 19. [Role of MEK/ERK pathway in the regulation of HDACI-induced senescence of transformed rat embryo fibroblasts].
    Kochetkova EIu, Bykova TV, Zubova SG, Pospelova TV.
    Tsitologiia; 2014 Apr 01; 56(8):581-90. PubMed ID: 25697003
    [Abstract] [Full Text] [Related]

  • 20. ATP-site binding inhibitor effectively targets mTORC1 and mTORC2 complexes in glioblastoma.
    Neil J, Shannon C, Mohan A, Laurent D, Murali R, Jhanwar-Uniyal M.
    Int J Oncol; 2016 Mar 01; 48(3):1045-52. PubMed ID: 26719046
    [Abstract] [Full Text] [Related]

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