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164 related items for PubMed ID: 30361333

  • 1. Constitutive androstane receptor 1 is constitutively bound to chromatin and 'primed' for transactivation in hepatocytes.
    McMahon M, Ding S, Jimenez LA, Terranova R, Gerard MA, Vitobello A, Moggs J, Henderson CJ, Wolf CR.
    Mol Pharmacol; 2019 Jan; 95(1):97-105. PubMed ID: 30361333
    [Abstract] [Full Text] [Related]

  • 2. Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver.
    Guo D, Sarkar J, Ahmed MR, Viswakarma N, Jia Y, Yu S, Sambasiva Rao M, Reddy JK.
    Biochem Biophys Res Commun; 2006 Aug 25; 347(2):485-95. PubMed ID: 16828057
    [Abstract] [Full Text] [Related]

  • 3. Multi-species analyses of direct activators of the constitutive androstane receptor.
    Omiecinski CJ, Coslo DM, Chen T, Laurenzana EM, Peffer RC.
    Toxicol Sci; 2011 Oct 25; 123(2):550-62. PubMed ID: 21778469
    [Abstract] [Full Text] [Related]

  • 4. Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes.
    Haines C, Elcombe BM, Chatham LR, Vardy A, Higgins LG, Elcombe CR, Lake BG.
    Toxicology; 2018 Mar 01; 396-397():23-32. PubMed ID: 29425889
    [Abstract] [Full Text] [Related]

  • 5. Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivo.
    Min G, Kemper JK, Kemper B.
    J Biol Chem; 2002 Jul 19; 277(29):26356-63. PubMed ID: 12000748
    [Abstract] [Full Text] [Related]

  • 6. Extracellular signal-regulated kinase is an endogenous signal retaining the nuclear constitutive active/androstane receptor (CAR) in the cytoplasm of mouse primary hepatocytes.
    Koike C, Moore R, Negishi M.
    Mol Pharmacol; 2007 May 19; 71(5):1217-21. PubMed ID: 17314319
    [Abstract] [Full Text] [Related]

  • 7. Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.
    Shizu R, Benoki S, Numakura Y, Kodama S, Miyata M, Yamazoe Y, Yoshinari K.
    PLoS One; 2013 May 19; 8(4):e61802. PubMed ID: 23626729
    [Abstract] [Full Text] [Related]

  • 8. Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2.
    DeKeyser JG, Stagliano MC, Auerbach SS, Prabhu KS, Jones AD, Omiecinski CJ.
    Mol Pharmacol; 2009 May 19; 75(5):1005-13. PubMed ID: 19211671
    [Abstract] [Full Text] [Related]

  • 9. Comparative studies on the effects of sodium phenobarbital and two other constitutive androstane receptor (CAR) activators on induction of cytochrome P450 enzymes and replicative DNA synthesis in cultured hepatocytes from wild type and CAR knockout rats.
    Goettel M, Fegert I, Honarvar N, Vardy A, Haines C, Chatham LR, Lake BG.
    Toxicology; 2020 Mar 30; 433-434():152394. PubMed ID: 32027962
    [Abstract] [Full Text] [Related]

  • 10. Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation.
    Pascussi JM, Gerbal-Chaloin S, Fabre JM, Maurel P, Vilarem MJ.
    Mol Pharmacol; 2000 Dec 30; 58(6):1441-50. PubMed ID: 11093784
    [Abstract] [Full Text] [Related]

  • 11. Chromatin assembly enhances binding to the CYP2B1 phenobarbital-responsive unit (PBRU) of nuclear factor-1, which binds simultaneously with constitutive androstane receptor (CAR)/retinoid X receptor (RXR) and enhances CAR/RXR-mediated activation of the PBRU.
    Kim J, Min G, Kemper B.
    J Biol Chem; 2001 Mar 09; 276(10):7559-67. PubMed ID: 11113125
    [Abstract] [Full Text] [Related]

  • 12. Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling.
    Mutoh S, Sobhany M, Moore R, Perera L, Pedersen L, Sueyoshi T, Negishi M.
    Sci Signal; 2013 May 07; 6(274):ra31. PubMed ID: 23652203
    [Abstract] [Full Text] [Related]

  • 13. Indirect activation of constitutive androstane receptor in three-dimensionally cultured HepG2 cells.
    Yokobori K, Azuma I, Chiba K, Akita H, Furihata T, Kobayashi K.
    Biochem Pharmacol; 2019 Oct 07; 168():26-37. PubMed ID: 31202736
    [Abstract] [Full Text] [Related]

  • 14. Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression.
    Roth A, Looser R, Kaufmann M, Blättler SM, Rencurel F, Huang W, Moore DD, Meyer UA.
    Mol Pharmacol; 2008 Apr 07; 73(4):1282-9. PubMed ID: 18187584
    [Abstract] [Full Text] [Related]

  • 15. Identification of novel agonists by high-throughput screening and molecular modelling of human constitutive androstane receptor isoform 3.
    Keminer O, Windshügel B, Essmann F, Lee SML, Schiergens TS, Schwab M, Burk O.
    Arch Toxicol; 2019 Aug 07; 93(8):2247-2264. PubMed ID: 31312845
    [Abstract] [Full Text] [Related]

  • 16. Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid.
    Abe T, Takahashi M, Kano M, Amaike Y, Ishii C, Maeda K, Kudoh Y, Morishita T, Hosaka T, Sasaki T, Kodama S, Matsuzawa A, Kojima H, Yoshinari K.
    Arch Toxicol; 2017 Jun 07; 91(6):2365-2374. PubMed ID: 27832320
    [Abstract] [Full Text] [Related]

  • 17. Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors.
    Paul KB, Thompson JT, Simmons SO, Vanden Heuvel JP, Crofton KM.
    Toxicol In Vitro; 2013 Oct 07; 27(7):2049-60. PubMed ID: 23899473
    [Abstract] [Full Text] [Related]

  • 18. Antiepileptic Drug-Activated Constitutive Androstane Receptor Inhibits Peroxisome Proliferator-Activated Receptor α and Peroxisome Proliferator-Activated Receptor γ Coactivator 1α-Dependent Gene Expression to Increase Blood Triglyceride Levels.
    Shizu R, Otsuka Y, Ezaki K, Ishii C, Arakawa S, Amaike Y, Abe T, Hosaka T, Sasaki T, Kanno Y, Miyata M, Yamazoe Y, Yoshinari K.
    Mol Pharmacol; 2020 Nov 07; 98(5):634-647. PubMed ID: 32892155
    [Abstract] [Full Text] [Related]

  • 19. Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR).
    Yamada T, Cohen SM, Lake BG.
    Crit Rev Toxicol; 2021 May 07; 51(5):373-394. PubMed ID: 34264181
    [Abstract] [Full Text] [Related]

  • 20. Transcriptional activation of PPARalpha by phenobarbital in the absence of CAR and PXR.
    Tamasi V, Juvan P, Beer M, Rozman D, Meyer UA.
    Mol Pharm; 2009 May 07; 6(5):1573-81. PubMed ID: 19708687
    [Abstract] [Full Text] [Related]

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