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Journal Abstract Search

221 related items for PubMed ID: 30385225

  • 1. 1H-pyrrolo[2,3-b]pyridine: A new scaffold for human neutrophil elastase (HNE) inhibitors.
    Crocetti L, Giovannoni MP, Schepetkin IA, Quinn MT, Khlebnikov AI, Cantini N, Guerrini G, Iacovone A, Teodori E, Vergelli C.
    Bioorg Med Chem; 2018 Nov 15; 26(21):5583-5595. PubMed ID: 30385225
    [Abstract] [Full Text] [Related]

  • 2. Further modifications of 1H-pyrrolo[2,3-b]pyridine derivatives as inhibitors of human neutrophil elastase.
    Giovannoni MP, Cantini N, Crocetti L, Guerrini G, Iacovone A, Schepetkin IA, Vergelli C, Khlebnikov AI, Quinn MT.
    Drug Dev Res; 2019 Aug 15; 80(5):617-628. PubMed ID: 31002441
    [Abstract] [Full Text] [Related]

  • 3. Exploration of nitrogen heterocycle scaffolds for the development of potent human neutrophil elastase inhibitors.
    Cantini N, Khlebnikov AI, Crocetti L, Schepetkin IA, Floresta G, Guerrini G, Vergelli C, Bartolucci G, Quinn MT, Giovannoni MP.
    Bioorg Med Chem; 2021 Jan 01; 29():115836. PubMed ID: 33218895
    [Abstract] [Full Text] [Related]

  • 4. Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors.
    Vergelli C, Schepetkin IA, Crocetti L, Iacovone A, Giovannoni MP, Guerrini G, Khlebnikov AI, Ciattini S, Ciciani G, Quinn MT.
    J Enzyme Inhib Med Chem; 2017 Dec 01; 32(1):821-831. PubMed ID: 28612630
    [Abstract] [Full Text] [Related]

  • 5. 1,5,6,7-Tetrahydro-4H-indazol-4-ones as human neutrophil elastase (HNE) inhibitors.
    Cantini N, Crocetti L, Guerrini G, Vergelli C, Schepetkin IA, Pallecchi M, Bartolucci G, Quinn MT, Teodori E, Giovannoni MP.
    Bioorg Med Chem Lett; 2021 Nov 15; 52():128380. PubMed ID: 34563669
    [Abstract] [Full Text] [Related]

  • 6. Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase.
    Crocetti L, Schepetkin IA, Cilibrizzi A, Graziano A, Vergelli C, Giomi D, Khlebnikov AI, Quinn MT, Giovannoni MP.
    J Med Chem; 2013 Aug 08; 56(15):6259-72. PubMed ID: 23844670
    [Abstract] [Full Text] [Related]

  • 7. Cinnoline derivatives as human neutrophil elastase inhibitors.
    Giovannoni MP, Schepetkin IA, Crocetti L, Ciciani G, Cilibrizzi A, Guerrini G, Khlebnikov AI, Quinn MT, Vergelli C.
    J Enzyme Inhib Med Chem; 2016 Aug 08; 31(4):628-39. PubMed ID: 26194018
    [Abstract] [Full Text] [Related]

  • 8. Discovery of a series of 1H-pyrrolo[2,3-b]pyridine compounds as potent TNIK inhibitors.
    Yang B, Wu Q, Huan X, Wang Y, Sun Y, Yang Y, Liu T, Wang X, Chen L, Xiong B, Zhao D, Miao Z, Chen D.
    Bioorg Med Chem Lett; 2021 Feb 01; 33():127749. PubMed ID: 33340663
    [Abstract] [Full Text] [Related]

  • 9. Synthesis, biological evaluation, and docking studies of novel pyrrolo[2,3-b]pyridine derivatives as both ectonucleotide pyrophosphatase/phosphodiesterase inhibitors and antiproliferative agents.
    Ullah S, El-Gamal MI, El-Gamal R, Pelletier J, Sévigny J, Shehata MK, Anbar HS, Iqbal J.
    Eur J Med Chem; 2021 May 05; 217():113339. PubMed ID: 33744686
    [Abstract] [Full Text] [Related]

  • 10. SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase.
    Zheng Q, Woehl JL, Kitamura S, Santos-Martins D, Smedley CJ, Li G, Forli S, Moses JE, Wolan DW, Sharpless KB.
    Proc Natl Acad Sci U S A; 2019 Sep 17; 116(38):18808-18814. PubMed ID: 31484779
    [Abstract] [Full Text] [Related]

  • 11. Ahp-Cyclodepsipeptides as tunable inhibitors of human neutrophil elastase and kallikrein 7: Total synthesis of tutuilamide A, serine protease selectivity profile and comparison with lyngbyastatin 7.
    Chen QY, Luo D, Seabra GM, Luesch H.
    Bioorg Med Chem; 2020 Dec 01; 28(23):115756. PubMed ID: 33002682
    [Abstract] [Full Text] [Related]

  • 12.
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  • 13. Design, synthesis, and in vitro evaluation of inhibitors of human leukocyte elastase based on a functionalized cyclic sulfamide scaffold.
    Zhong J, Gan X, Alliston KR, Groutas WC.
    Bioorg Med Chem; 2004 Feb 01; 12(3):589-93. PubMed ID: 14738969
    [Abstract] [Full Text] [Related]

  • 14. X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives.
    Huang W, Yamamoto Y, Li Y, Dou D, Alliston KR, Hanzlik RP, Williams TD, Groutas WC.
    J Med Chem; 2008 Apr 10; 51(7):2003-8. PubMed ID: 18318470
    [Abstract] [Full Text] [Related]

  • 15. Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151).
    Macdonald SJ, Dowle MD, Harrison LA, Clarke GD, Inglis GG, Johnson MR, Shah P, Smith RA, Amour A, Fleetwood G, Humphreys DC, Molloy CR, Dixon M, Godward RE, Wonacott AJ, Singh OM, Hodgson ST, Hardy GW.
    J Med Chem; 2002 Aug 29; 45(18):3878-90. PubMed ID: 12190311
    [Abstract] [Full Text] [Related]

  • 16. New 3-unsubstituted isoxazolones as potent human neutrophil elastase inhibitors: Synthesis and molecular dynamic simulation.
    Giovannoni MP, Crocetti L, Cantini N, Guerrini G, Vergelli C, Iacovone A, Teodori E, Schepetkin IA, Quinn MT, Ciattini S, Rossi P, Paoli P.
    Drug Dev Res; 2020 May 29; 81(3):338-349. PubMed ID: 31800122
    [Abstract] [Full Text] [Related]

  • 17.
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  • 18. Synthesis, and docking studies of phenylpyrimidine-carboxamide derivatives bearing 1H-pyrrolo[2,3-b]pyridine moiety as c-Met inhibitors.
    Zhu W, Wang W, Xu S, Wang J, Tang Q, Wu C, Zhao Y, Zheng P.
    Bioorg Med Chem; 2016 Apr 15; 24(8):1749-56. PubMed ID: 26964675
    [Abstract] [Full Text] [Related]

  • 19. Neutrophil elastase inhibitors: recent advances in the development of mechanism-based and nonelectrophilic inhibitors.
    Sjö P.
    Future Med Chem; 2012 Apr 15; 4(5):651-60. PubMed ID: 22458683
    [Abstract] [Full Text] [Related]

  • 20. Synthesis, molecular docking, antimycobacterial and antimicrobial evaluation of new pyrrolo[3,2-c]pyridine Mannich bases.
    Jose G, Suresha Kumara TH, Sowmya HBV, Sriram D, Guru Row TN, Hosamani AA, More SS, Janardhan B, Harish BG, Telkar S, Ravikumar YS.
    Eur J Med Chem; 2017 May 05; 131():275-288. PubMed ID: 28340368
    [Abstract] [Full Text] [Related]

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