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Journal Abstract Search

272 related items for PubMed ID: 30395703

  • 1. Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility.
    Naylor MR, Ly AM, Handford MJ, Ramos DP, Pye CR, Furukawa A, Klein VG, Noland RP, Edmondson Q, Turmon AC, Hewitt WM, Schwochert J, Townsend CE, Kelly CN, Blanco MJ, Lokey RS.
    J Med Chem; 2018 Dec 27; 61(24):11169-11182. PubMed ID: 30395703
    [Abstract] [Full Text] [Related]

  • 2. Optimization of Cyclic Peptide Property Using Chromatographic Capacity Factor on Permeability of Passive Cell Membrane and Human Induced Pluripotent Stem Cell-Derived Intestinal Membrane.
    Watanabe A, Uehara S, Akazawa T, Fujiu M.
    J Pharm Sci; 2022 Jul 27; 111(7):1879-1886. PubMed ID: 35385719
    [Abstract] [Full Text] [Related]

  • 3. Lipophilic and electrostatic forces encoded in IAM-HPLC indexes of basic drugs: their role in membrane partition and their relationships with BBB passage data.
    Grumetto L, Carpentiero C, Barbato F.
    Eur J Pharm Sci; 2012 Apr 11; 45(5):685-92. PubMed ID: 22306648
    [Abstract] [Full Text] [Related]

  • 4. Facts, Patterns, and Principles in Drug Discovery: Appraising the Rule of 5 with Measured Physicochemical Data.
    Tinworth CP, Young RJ.
    J Med Chem; 2020 Sep 24; 63(18):10091-10108. PubMed ID: 32324397
    [Abstract] [Full Text] [Related]

  • 5. Lipophilicity of amphoteric and zwitterionic compounds: A comparative study of determination methods.
    Ràfols C, Subirats X, Rubio J, Rosés M, Bosch E.
    Talanta; 2017 Jan 01; 162():293-299. PubMed ID: 27837832
    [Abstract] [Full Text] [Related]

  • 6. Physicochemical profiling (solubility, permeability and charge state).
    Avdeef A.
    Curr Top Med Chem; 2001 Sep 01; 1(4):277-351. PubMed ID: 11899112
    [Abstract] [Full Text] [Related]

  • 7. Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight.
    Camenisch G, Alsenz J, van de Waterbeemd H, Folkers G.
    Eur J Pharm Sci; 1998 Oct 01; 6(4):317-24. PubMed ID: 9795088
    [Abstract] [Full Text] [Related]

  • 8. Molecular inflation, attrition and the rule of five.
    Leeson PD.
    Adv Drug Deliv Rev; 2016 Jun 01; 101():22-33. PubMed ID: 26836397
    [Abstract] [Full Text] [Related]

  • 9. Setup and validation of shake-flask procedures for the determination of partition coefficients (logD) from low drug amounts.
    Andrés A, Rosés M, Ràfols C, Bosch E, Espinosa S, Segarra V, Huerta JM.
    Eur J Pharm Sci; 2015 Aug 30; 76():181-91. PubMed ID: 25968358
    [Abstract] [Full Text] [Related]

  • 10. Effect of Flexibility, Lipophilicity, and the Location of Polar Residues on the Passive Membrane Permeability of a Series of Cyclic Decapeptides.
    Wang S, König G, Roth HJ, Fouché M, Rodde S, Riniker S.
    J Med Chem; 2021 Sep 09; 64(17):12761-12773. PubMed ID: 34406766
    [Abstract] [Full Text] [Related]

  • 11. Getting physical in drug discovery: a contemporary perspective on solubility and hydrophobicity.
    Hill AP, Young RJ.
    Drug Discov Today; 2010 Aug 09; 15(15-16):648-55. PubMed ID: 20570751
    [Abstract] [Full Text] [Related]

  • 12. Measurement of diffusion coefficients of parabens and steroids in water and 1-octanol.
    Seki T, Mochida J, Okamoto M, Hosoya O, Juni K, Morimoto K.
    Chem Pharm Bull (Tokyo); 2003 Jun 09; 51(6):734-6. PubMed ID: 12808257
    [Abstract] [Full Text] [Related]

  • 13. High lipophilicity of perfluoroalkyl carboxylate and sulfonate: implications for their membrane permeability.
    Jing P, Rodgers PJ, Amemiya S.
    J Am Chem Soc; 2009 Feb 18; 131(6):2290-6. PubMed ID: 19170492
    [Abstract] [Full Text] [Related]

  • 14. Lipophilicity assessment of basic drugs (log P(o/w) determination) by a chromatographic method.
    Pallicer JM, Sales J, Rosés M, Ràfols C, Bosch E.
    J Chromatogr A; 2011 Sep 16; 1218(37):6356-68. PubMed ID: 21820118
    [Abstract] [Full Text] [Related]

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  • 16. Lipophilic and polar interaction forces between acidic drugs and membrane phospholipids encoded in IAM-HPLC indexes: their role in membrane partition and relationships with BBB permeation data.
    Grumetto L, Carpentiero C, Di Vaio P, Frecentese F, Barbato F.
    J Pharm Biomed Anal; 2013 Mar 05; 75():165-72. PubMed ID: 23261809
    [Abstract] [Full Text] [Related]

  • 17.
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  • 18. Prediction of pH-Dependent Hydrophobic Profiles of Small Molecules from Miertus-Scrocco-Tomasi Continuum Solvation Calculations.
    Zamora WJ, Curutchet C, Campanera JM, Luque FJ.
    J Phys Chem B; 2017 Oct 26; 121(42):9868-9880. PubMed ID: 28957625
    [Abstract] [Full Text] [Related]

  • 19. Comparison between immobilized artificial membrane (IAM) HPLC data and lipophilicity in n-octanol for quinolone antibacterial agents.
    Barbato F, Cirocco V, Grumetto L, Immacolata La Rotonda M.
    Eur J Pharm Sci; 2007 Aug 26; 31(5):288-97. PubMed ID: 17540545
    [Abstract] [Full Text] [Related]

  • 20. Quasi-equilibrium analysis of the ion-pair mediated membrane transport of low-permeability drugs.
    Miller JM, Dahan A, Gupta D, Varghese S, Amidon GL.
    J Control Release; 2009 Jul 01; 137(1):31-7. PubMed ID: 19264104
    [Abstract] [Full Text] [Related]

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