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Journal Abstract Search

267 related items for PubMed ID: 30576102

  • 1. Human CYP2A6, CYP2B6, AND CYP2E1 Atropselectively Metabolize Polychlorinated Biphenyls to Hydroxylated Metabolites.
    Uwimana E, Ruiz P, Li X, Lehmler HJ.
    Environ Sci Technol; 2019 Feb 19; 53(4):2114-2123. PubMed ID: 30576102
    [Abstract] [Full Text] [Related]

  • 2. Human Liver Microsomes Atropselectively Metabolize 2,2',3,4',6-Pentachlorobiphenyl (PCB 91) to a 1,2-Shift Product as the Major Metabolite.
    Uwimana E, Li X, Lehmler HJ.
    Environ Sci Technol; 2018 May 15; 52(10):6000-6008. PubMed ID: 29659268
    [Abstract] [Full Text] [Related]

  • 3. Atropselective Disposition of 2,2',3,4',6-Pentachlorobiphenyl (PCB 91) and Identification of Its Metabolites in Mice with Liver-Specific Deletion of Cytochrome P450 Reductase.
    Wu X, Zhai G, Schnoor JL, Lehmler HJ.
    Chem Res Toxicol; 2020 Jun 15; 33(6):1328-1338. PubMed ID: 31403789
    [Abstract] [Full Text] [Related]

  • 4. Metabolic activation of WHO-congeners PCB28, 52, and 101 by human CYP2A6: evidence from in vitro and in vivo experiments.
    Randerath I, Schettgen T, Müller JP, Rengelshausen J, Ziegler S, Quinete N, Bertram J, Laieb S, Schaeffeler E, Kaifie A, Just KS, Voigt A, Tremmel R, Schwab M, Stingl JC, Kraus T, Ziegler P.
    Arch Toxicol; 2024 Nov 15; 98(11):3739-3753. PubMed ID: 39136732
    [Abstract] [Full Text] [Related]

  • 5. Oxidation of polychlorinated biphenyls by liver tissue slices from phenobarbital-pretreated mice is congener-specific and atropselective.
    Wu X, Duffel M, Lehmler HJ.
    Chem Res Toxicol; 2013 Nov 18; 26(11):1642-51. PubMed ID: 24107130
    [Abstract] [Full Text] [Related]

  • 6. 2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) is enantioselectively oxidized to hydroxylated metabolites by rat liver microsomes.
    Wu X, Pramanik A, Duffel MW, Hrycay EG, Bandiera SM, Lehmler HJ, Kania-Korwel I.
    Chem Res Toxicol; 2011 Dec 19; 24(12):2249-57. PubMed ID: 22026639
    [Abstract] [Full Text] [Related]

  • 7. Chiral polychlorinated biphenyls are biotransformed enantioselectively by mammalian cytochrome P-450 isozymes to form hydroxylated metabolites.
    Warner NA, Martin JW, Wong CS.
    Environ Sci Technol; 2009 Jan 01; 43(1):114-21. PubMed ID: 19209593
    [Abstract] [Full Text] [Related]

  • 8. Probing the Role of CYP2 Enzymes in the Atropselective Metabolism of Polychlorinated Biphenyls Using Liver Microsomes from Transgenic Mouse Models.
    Lehmler HJ, Uwimana E, Dean LE, Kovalchuk N, Zhang QY, Ding X.
    Chem Res Toxicol; 2022 Dec 19; 35(12):2310-2323. PubMed ID: 36473170
    [Abstract] [Full Text] [Related]

  • 9. Microsomal oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) results in species-dependent chiral signatures of the hydroxylated metabolites.
    Wu X, Kammerer A, Lehmler HJ.
    Environ Sci Technol; 2014 Feb 18; 48(4):2436-44. PubMed ID: 24467194
    [Abstract] [Full Text] [Related]

  • 10. Differences in Enantioselective Hydroxylation of 2,2',3,6-Tetrachlorobiphenyl (CB45) and 2,2',3,4',6-Pentachlorobiphenyl (CB91) by Human and Rat CYP2B Subfamilies.
    Inui H, Ito T, Miwa C, Haga Y, Kubo M, Itoh T, Yamamoto K, Miyaoka M, Mori T, Tsuzuki H, Mise S, Goto E, Matsumura C, Nakano T.
    Environ Sci Technol; 2022 Jul 19; 56(14):10204-10215. PubMed ID: 35801261
    [Abstract] [Full Text] [Related]

  • 11. Identification of a novel hydroxylated metabolite of 2,2',3,5',6-pentachlorobiphenyl formed in whole poplar plants.
    Ma C, Zhai G, Wu H, Kania-Korwel I, Lehmler HJ, Schnoor JL.
    Environ Sci Pollut Res Int; 2016 Feb 19; 23(3):2089-98. PubMed ID: 26676542
    [Abstract] [Full Text] [Related]

  • 12. Chiral polychlorinated biphenyls: absorption, metabolism and excretion--a review.
    Kania-Korwel I, Lehmler HJ.
    Environ Sci Pollut Res Int; 2016 Feb 19; 23(3):2042-57. PubMed ID: 25651810
    [Abstract] [Full Text] [Related]

  • 13. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) Is Atropselectively Metabolized to para-Hydroxylated Metabolites by Human Liver Microsomes.
    Uwimana E, Li X, Lehmler HJ.
    Chem Res Toxicol; 2016 Dec 19; 29(12):2108-2110. PubMed ID: 27989147
    [Abstract] [Full Text] [Related]

  • 14. Effects of thiol antioxidants on the atropselective oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) by rat liver microsomes.
    Wu X, Lehmler HJ.
    Environ Sci Pollut Res Int; 2016 Feb 19; 23(3):2081-8. PubMed ID: 26155892
    [Abstract] [Full Text] [Related]

  • 15. Atropselective Oxidation of 2,2',3,3',4,6'-Hexachlorobiphenyl (PCB 132) to Hydroxylated Metabolites by Human Liver Microsomes and Its Implications for PCB 132 Neurotoxicity.
    Uwimana E, Cagle B, Yeung C, Li X, Patterson EV, Doorn JA, Lehmler HJ.
    Toxicol Sci; 2019 Oct 01; 171(2):406-420. PubMed ID: 31268529
    [Abstract] [Full Text] [Related]

  • 16. Microsomal Metabolism of Prochiral Polychlorinated Biphenyls Results in the Enantioselective Formation of Chiral Metabolites.
    Uwimana E, Maiers A, Li X, Lehmler HJ.
    Environ Sci Technol; 2017 Feb 07; 51(3):1820-1829. PubMed ID: 28038482
    [Abstract] [Full Text] [Related]

  • 17. Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat.
    Stamou M, Uwimana E, Flannery BM, Kania-Korwel I, Lehmler HJ, Lein PJ.
    Toxicology; 2015 Dec 02; 338():59-68. PubMed ID: 26463278
    [Abstract] [Full Text] [Related]

  • 18. Gas chromatographic analysis with chiral cyclodextrin phases reveals the enantioselective formation of hydroxylated polychlorinated biphenyls by rat liver microsomes.
    Kania-Korwel I, Duffel MW, Lehmler HJ.
    Environ Sci Technol; 2011 Nov 15; 45(22):9590-6. PubMed ID: 21966948
    [Abstract] [Full Text] [Related]

  • 19. Stereoselective formation of mono- and dihydroxylated polychlorinated biphenyls by rat cytochrome P450 2B1.
    Lu Z, Kania-Korwel I, Lehmler HJ, Wong CS.
    Environ Sci Technol; 2013 Nov 15; 47(21):12184-92. PubMed ID: 24060104
    [Abstract] [Full Text] [Related]

  • 20. Editor's Highlight: Congener-Specific Disposition of Chiral Polychlorinated Biphenyls in Lactating Mice and Their Offspring: Implications for PCB Developmental Neurotoxicity.
    Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera S, Lein PJ, Lehmler HJ.
    Toxicol Sci; 2017 Jul 01; 158(1):101-115. PubMed ID: 28431184
    [Abstract] [Full Text] [Related]

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