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Journal Abstract Search

157 related items for PubMed ID: 30638876

  • 1. Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity.
    Varano F, Catarzi D, Falsini M, Dal Ben D, Buccioni M, Marucci G, Volpini R, Colotta V.
    Bioorg Med Chem Lett; 2019 Feb 15; 29(4):563-569. PubMed ID: 30638876
    [Abstract] [Full Text] [Related]

  • 2. Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human A1 and A2A adenosine receptor antagonists/inverse agonists.
    Varano F, Catarzi D, Falsini M, Vincenzi F, Pasquini S, Varani K, Colotta V.
    Bioorg Med Chem; 2018 Jul 23; 26(12):3688-3695. PubMed ID: 29880250
    [Abstract] [Full Text] [Related]

  • 3. Exploring the 7-oxo-thiazolo[5,4-d]pyrimidine core for the design of new human adenosine A3 receptor antagonists. Synthesis, molecular modeling studies and pharmacological evaluation.
    Varano F, Catarzi D, Squarcialupi L, Betti M, Vincenzi F, Ravani A, Varani K, Dal Ben D, Thomas A, Volpini R, Colotta V.
    Eur J Med Chem; 2015 Jul 23; 96():105-21. PubMed ID: 25874336
    [Abstract] [Full Text] [Related]

  • 4. Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors.
    Squarcialupi L, Falsini M, Catarzi D, Varano F, Betti M, Varani K, Vincenzi F, Dal Ben D, Lambertucci C, Volpini R, Colotta V.
    Bioorg Med Chem; 2016 Jun 15; 24(12):2794-808. PubMed ID: 27161878
    [Abstract] [Full Text] [Related]

  • 5. The Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives.
    Federico S, Redenti S, Sturlese M, Ciancetta A, Kachler S, Klotz KN, Cacciari B, Moro S, Spalluto G.
    PLoS One; 2015 Jun 15; 10(12):e0143504. PubMed ID: 26625265
    [Abstract] [Full Text] [Related]

  • 6. [1,2,4]Triazolo[1,5-c]pyrimidines as adenosine receptor antagonists: Modifications at the 8 position to reach selectivity towards A3 adenosine receptor subtype.
    Federico S, Margiotta E, Salmaso V, Pastorin G, Kachler S, Klotz KN, Moro S, Spalluto G.
    Eur J Med Chem; 2018 Sep 05; 157():837-851. PubMed ID: 30144700
    [Abstract] [Full Text] [Related]

  • 7. Structure-activity relationship studies and pharmacological characterization of N5-heteroarylalkyl-substituted-2-(2-furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine-based derivatives as inverse agonists at human A2A adenosine receptor.
    Varano F, Catarzi D, Vincenzi F, Falsini M, Pasquini S, Borea PA, Colotta V, Varani K.
    Eur J Med Chem; 2018 Jul 15; 155():552-561. PubMed ID: 29909340
    [Abstract] [Full Text] [Related]

  • 8. Substituted 4-phenylthiazoles: Development of potent and selective A1, A3 and dual A1/A3 adenosine receptor antagonists.
    Abdelrahman A, Yerande SG, Namasivayam V, Klapschinski TA, Alnouri MW, El-Tayeb A, Müller CE.
    Eur J Med Chem; 2020 Jan 15; 186():111879. PubMed ID: 31780082
    [Abstract] [Full Text] [Related]

  • 9. 7-Substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists: a study on the importance of modifications at the side chain on the activity and solubility.
    Baraldi PG, Cacciari B, Romagnoli R, Spalluto G, Monopoli A, Ongini E, Varani K, Borea PA.
    J Med Chem; 2002 Jan 03; 45(1):115-26. PubMed ID: 11754583
    [Abstract] [Full Text] [Related]

  • 10. The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A2A Receptor Subtype.
    Falsini M, Squarcialupi L, Catarzi D, Varano F, Betti M, Dal Ben D, Marucci G, Buccioni M, Volpini R, De Vita T, Cavalli A, Colotta V.
    J Med Chem; 2017 Jul 13; 60(13):5772-5790. PubMed ID: 28590753
    [Abstract] [Full Text] [Related]

  • 11. Discovery of simplified N²-substituted pyrazolo[3,4-d]pyrimidine derivatives as novel adenosine receptor antagonists: efficient synthetic approaches, biological evaluations and molecular docking studies.
    Venkatesan G, Paira P, Cheong SL, Vamsikrishna K, Federico S, Klotz KN, Spalluto G, Pastorin G.
    Bioorg Med Chem; 2014 Mar 01; 22(5):1751-65. PubMed ID: 24518296
    [Abstract] [Full Text] [Related]

  • 12. Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines and Structurally Simplified Analogs. Chemistry and SAR Profile as Adenosine Receptor Antagonists.
    Redenti S, Ciancetta A, Pastorin G, Cacciari B, Moro S, Spalluto G, Federico S.
    Curr Top Med Chem; 2016 Mar 01; 16(28):3224-3257. PubMed ID: 27150365
    [Abstract] [Full Text] [Related]

  • 13. Chalcone-based derivatives as new scaffolds for hA3 adenosine receptor antagonists.
    Vazquez-Rodriguez S, Matos MJ, Santana L, Uriarte E, Borges F, Kachler S, Klotz KN.
    J Pharm Pharmacol; 2013 May 01; 65(5):697-703. PubMed ID: 23600387
    [Abstract] [Full Text] [Related]

  • 14. Synthesis of novel 7-imino-2-thioxo-3,7-dihydro-2H-thiazolo [4,5-d] pyrimidine derivatives as adenosine A2A receptor antagonists.
    Luthra PM, Mishra CB, Jha PK, Barodia SK.
    Bioorg Med Chem Lett; 2010 Feb 01; 20(3):1214-8. PubMed ID: 20018509
    [Abstract] [Full Text] [Related]

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  • 16. 7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: structural investigations at the 5-position to target human A₁ and A(2A) adenosine receptors. Molecular modeling and pharmacological studies.
    Squarcialupi L, Colotta V, Catarzi D, Varano F, Betti M, Varani K, Vincenzi F, Borea PA, Porta N, Ciancetta A, Moro S.
    Eur J Med Chem; 2014 Sep 12; 84():614-27. PubMed ID: 25063944
    [Abstract] [Full Text] [Related]

  • 17. Novel 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as potent human adenosine A1 and A2A receptor antagonists. Evaluation of their protective effect against β-amyloid-induced neurotoxicity in SH-SY5Y cells.
    Falsini M, Catarzi D, Varano F, Dal Ben D, Marucci G, Buccioni M, Volpini R, Di Cesare Mannelli L, Ghelardini C, Colotta V.
    Bioorg Chem; 2019 Jun 12; 87():380-394. PubMed ID: 30913470
    [Abstract] [Full Text] [Related]

  • 18. 2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists: The 6-Morpholino Derivatives.
    Areias F, Correia C, Rocha A, Teixeira S, Castro M, Brea J, Hu H, Carlsson J, Loza MI, Proença MF, Carvalho MA.
    Molecules; 2024 May 28; 29(11):. PubMed ID: 38893418
    [Abstract] [Full Text] [Related]

  • 19. New substituted 9-alkylpurines as adenosine receptor ligands.
    Camaioni E, Costanzi S, Vittori S, Volpini R, Klotz KN, Cristalli G.
    Bioorg Med Chem; 1998 May 28; 6(5):523-33. PubMed ID: 9629466
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