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Journal Abstract Search

343 related items for PubMed ID: 30824542

  • 1. A novel triazole, NMK-T-057, induces autophagic cell death in breast cancer cells by inhibiting γ-secretase-mediated activation of Notch signaling.
    Das A, Narayanam MK, Paul S, Mukhnerjee P, Ghosh S, Dastidar DG, Chakrabarty S, Ganguli A, Basu B, Pal M, Chatterji U, Banerjee SK, Karmakar P, Kumar D, Chakrabarti G.
    J Biol Chem; 2019 Apr 26; 294(17):6733-6750. PubMed ID: 30824542
    [Abstract] [Full Text] [Related]

  • 2. Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design.
    Wei P, Walls M, Qiu M, Ding R, Denlinger RH, Wong A, Tsaparikos K, Jani JP, Hosea N, Sands M, Randolph S, Smeal T.
    Mol Cancer Ther; 2010 Jun 26; 9(6):1618-28. PubMed ID: 20530712
    [Abstract] [Full Text] [Related]

  • 3. The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition.
    Han J, Ma I, Hendzel MJ, Allalunis-Turner J.
    Breast Cancer Res; 2009 Jun 26; 11(4):R57. PubMed ID: 19660128
    [Abstract] [Full Text] [Related]

  • 4. Cimigenoside functions as a novel γ-secretase inhibitor and inhibits the proliferation or metastasis of human breast cancer cells by γ-secretase/Notch axis.
    Jia H, Liu M, Wang X, Jiang Q, Wang S, Santhanam RK, Lv C, Zhao Q, Lu J.
    Pharmacol Res; 2021 Jul 26; 169():105686. PubMed ID: 34022397
    [Abstract] [Full Text] [Related]

  • 5. Function of Integrin-Linked Kinase in Modulating the Stemness of IL-6-Abundant Breast Cancer Cells by Regulating γ-Secretase-Mediated Notch1 Activation in Caveolae.
    Hsu EC, Kulp SK, Huang HL, Tu HJ, Salunke SB, Sullivan NJ, Sun D, Wicha MS, Shapiro CL, Chen CS.
    Neoplasia; 2015 Jun 26; 17(6):497-508. PubMed ID: 26152358
    [Abstract] [Full Text] [Related]

  • 6. Bulbine frutescens phytochemical inhibits notch signaling pathway and induces apoptosis in triple negative and luminal breast cancer cells.
    Kushwaha PP, Vardhan PS, Kapewangolo P, Shuaib M, Prajapati SK, Singh AK, Kumar S.
    Life Sci; 2019 Oct 01; 234():116783. PubMed ID: 31442552
    [Abstract] [Full Text] [Related]

  • 7. Evidence that gamma-secretase-mediated Notch signaling induces neuronal cell death via the nuclear factor-kappaB-Bcl-2-interacting mediator of cell death pathway in ischemic stroke.
    Arumugam TV, Cheng YL, Choi Y, Choi YH, Yang S, Yun YK, Park JS, Yang DK, Thundyil J, Gelderblom M, Karamyan VT, Tang SC, Chan SL, Magnus T, Sobey CG, Jo DG.
    Mol Pharmacol; 2011 Jul 01; 80(1):23-31. PubMed ID: 21450930
    [Abstract] [Full Text] [Related]

  • 8. Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.
    Efferson CL, Winkelmann CT, Ware C, Sullivan T, Giampaoli S, Tammam J, Patel S, Mesiti G, Reilly JF, Gibson RE, Buser C, Yeatman T, Coppola D, Winter C, Clark EA, Draetta GF, Strack PR, Majumder PK.
    Cancer Res; 2010 Mar 15; 70(6):2476-84. PubMed ID: 20197467
    [Abstract] [Full Text] [Related]

  • 9. Notch Signaling in Breast Cancer: A Role in Drug Resistance.
    BeLow M, Osipo C.
    Cells; 2020 Sep 29; 9(10):. PubMed ID: 33003540
    [Abstract] [Full Text] [Related]

  • 10. A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells.
    Saito N, Fu J, Zheng S, Yao J, Wang S, Liu DD, Yuan Y, Sulman EP, Lang FF, Colman H, Verhaak RG, Yung WK, Koul D.
    Stem Cells; 2014 Jan 29; 32(1):301-12. PubMed ID: 24038660
    [Abstract] [Full Text] [Related]

  • 11. Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers.
    Konishi J, Kawaguchi KS, Vo H, Haruki N, Gonzalez A, Carbone DP, Dang TP.
    Cancer Res; 2007 Sep 01; 67(17):8051-7. PubMed ID: 17804716
    [Abstract] [Full Text] [Related]

  • 12. NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications.
    Clementz AG, Rogowski A, Pandya K, Miele L, Osipo C.
    Breast Cancer Res; 2011 Jun 14; 13(3):R63. PubMed ID: 21679465
    [Abstract] [Full Text] [Related]

  • 13. Notch inhibition restores TRAIL-mediated apoptosis via AP1-dependent upregulation of DR4 and DR5 TRAIL receptors in MDA-MB-231 breast cancer cells.
    Portanova P, Notaro A, Pellerito O, Sabella S, Giuliano M, Calvaruso G.
    Int J Oncol; 2013 Jul 14; 43(1):121-30. PubMed ID: 23686163
    [Abstract] [Full Text] [Related]

  • 14. Alpha-secretase inhibition reduces human glioblastoma stem cell growth in vitro and in vivo by inhibiting Notch.
    Floyd DH, Kefas B, Seleverstov O, Mykhaylyk O, Dominguez C, Comeau L, Plank C, Purow B.
    Neuro Oncol; 2012 Oct 14; 14(10):1215-26. PubMed ID: 22962413
    [Abstract] [Full Text] [Related]

  • 15. Gamma-Secretase Inhibitor IX (GSI) Impairs Concomitant Activation of Notch and Wnt-Beta-Catenin Pathways in CD44+ Gastric Cancer Stem Cells.
    Barat S, Chen X, Cuong Bui K, Bozko P, Götze J, Christgen M, Krech T, Malek NP, Plentz RR.
    Stem Cells Transl Med; 2017 Mar 14; 6(3):819-829. PubMed ID: 28186678
    [Abstract] [Full Text] [Related]

  • 16. Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells.
    Rasul S, Balasubramanian R, Filipović A, Slade MJ, Yagüe E, Coombes RC.
    Br J Cancer; 2009 Jun 16; 100(12):1879-88. PubMed ID: 19513078
    [Abstract] [Full Text] [Related]

  • 17. Inhibition of γ-secretase/Notch pathway as a potential therapy for reversing cancer drug resistance.
    Feng M, Santhanam RK, Xing H, Zhou M, Jia H.
    Biochem Pharmacol; 2024 Feb 16; 220():115991. PubMed ID: 38135129
    [Abstract] [Full Text] [Related]

  • 18. Targeting Met and Notch in the Lfng-deficient, Met-amplified triple-negative breast cancer.
    Zhang S, Chung WC, Miele L, Xu K.
    Cancer Biol Ther; 2014 May 16; 15(5):633-42. PubMed ID: 24556651
    [Abstract] [Full Text] [Related]

  • 19. Combination therapy of RY10-4 with the γ-secretase inhibitor DAPT shows promise in treating HER2-amplified breast cancer.
    Su F, Zhu S, Ruan J, Muftuoglu Y, Zhang L, Yuan Q.
    Oncotarget; 2016 Jan 26; 7(4):4142-54. PubMed ID: 26716652
    [Abstract] [Full Text] [Related]

  • 20. Curcumin induces cell death in esophageal cancer cells through modulating Notch signaling.
    Subramaniam D, Ponnurangam S, Ramamoorthy P, Standing D, Battafarano RJ, Anant S, Sharma P.
    PLoS One; 2012 Jan 26; 7(2):e30590. PubMed ID: 22363450
    [Abstract] [Full Text] [Related]

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