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Journal Abstract Search

227 related items for PubMed ID: 30885958

  • 1. Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.
    Thilakasiri P, Huynh J, Poh AR, Tan CW, Nero TL, Tran K, Parslow AC, Afshar-Sterle S, Baloyan D, Hannan NJ, Buchert M, Scott AM, Griffin MD, Hollande F, Parker MW, Putoczki TL, Ernst M, Chand AL.
    EMBO Mol Med; 2019 Apr; 11(4):. PubMed ID: 30885958
    [Abstract] [Full Text] [Related]

  • 2. Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy.
    Wu X, Cao Y, Xiao H, Li C, Lin J.
    Mol Cancer Ther; 2016 Nov; 15(11):2609-2619. PubMed ID: 27535971
    [Abstract] [Full Text] [Related]

  • 3. Bazedoxifene as a novel GP130 inhibitor for Colon Cancer therapy.
    Wei J, Ma L, Lai YH, Zhang R, Li H, Li C, Lin J.
    J Exp Clin Cancer Res; 2019 Feb 08; 38(1):63. PubMed ID: 30736824
    [Abstract] [Full Text] [Related]

  • 4. Down-regulating IL-6/GP130 targets improved the anti-tumor effects of 5-fluorouracil in colon cancer.
    Li S, Tian J, Zhang H, Zhou S, Wang X, Zhang L, Yang J, Zhang Z, Ji Z.
    Apoptosis; 2018 Jun 08; 23(5-6):356-374. PubMed ID: 29777330
    [Abstract] [Full Text] [Related]

  • 5. Repositioning Bazedoxifene as a novel IL-6/GP130 signaling antagonist for human rhabdomyosarcoma therapy.
    Xiao H, Bid HK, Chen X, Wu X, Wei J, Bian Y, Zhao C, Li H, Li C, Lin J.
    PLoS One; 2017 Jun 08; 12(7):e0180297. PubMed ID: 28672024
    [Abstract] [Full Text] [Related]

  • 6. Inhibition of GP130/STAT3 and EMT by combined bazedoxifene and paclitaxel treatment in ovarian cancer.
    Park SA, Kim LK, Park HM, Kim HJ, Heo TH.
    Oncol Rep; 2022 Mar 08; 47(3):. PubMed ID: 35029286
    [Abstract] [Full Text] [Related]

  • 7. Bazedoxifene is a novel IL-6/GP130 inhibitor for treating triple-negative breast cancer.
    Tian J, Chen X, Fu S, Zhang R, Pan L, Cao Y, Wu X, Xiao H, Lin HJ, Lo HW, Zhang Y, Lin J.
    Breast Cancer Res Treat; 2019 Jun 08; 175(3):553-566. PubMed ID: 30852762
    [Abstract] [Full Text] [Related]

  • 8. Bazedoxifene, a GP130 Inhibitor, Modulates EMT Signaling and Exhibits Antitumor Effects in HPV-Positive Cervical Cancer.
    Kim L, Park SA, Park H, Kim H, Heo TH.
    Int J Mol Sci; 2021 Aug 13; 22(16):. PubMed ID: 34445405
    [Abstract] [Full Text] [Related]

  • 9. Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.
    Phesse TJ, Buchert M, Stuart E, Flanagan DJ, Faux M, Afshar-Sterle S, Walker F, Zhang HH, Nowell CJ, Jorissen R, Tan CW, Hirokawa Y, Eissmann MF, Poh AR, Malaterre J, Pearson HB, Kirsch DG, Provero P, Poli V, Ramsay RG, Sieber O, Burgess AW, Huszar D, Vincan E, Ernst M.
    Sci Signal; 2014 Sep 30; 7(345):ra92. PubMed ID: 25270258
    [Abstract] [Full Text] [Related]

  • 10. Blocking IL-6/GP130 Signaling Inhibits Cell Viability/Proliferation, Glycolysis, and Colony Forming Activity in Human Pancreatic Cancer Cells.
    Chen X, Tian J, Su GH, Lin J.
    Curr Cancer Drug Targets; 2019 Sep 30; 19(5):417-427. PubMed ID: 29714141
    [Abstract] [Full Text] [Related]

  • 11. Growth-suppressive activity of raloxifene on liver cancer cells by targeting IL-6/GP130 signaling.
    Wang Y, Ma H, Zhao C, Liu T, Yan D, Jou D, Li H, Zhang C, Lü J, Li C, Lin J, Li S, Lin L.
    Oncotarget; 2017 May 16; 8(20):33683-33693. PubMed ID: 28430601
    [Abstract] [Full Text] [Related]

  • 12. Bazedoxifene exhibits growth suppressive activity by targeting interleukin-6/glycoprotein 130/signal transducer and activator of transcription 3 signaling in hepatocellular carcinoma.
    Ma H, Yan D, Wang Y, Shi W, Liu T, Zhao C, Huo S, Duan J, Tao J, Zhai M, Luo P, Guo J, Tian L, Mageta L, Jou D, Zhang C, Li C, Lin J, Lv J, Li S, Lin L.
    Cancer Sci; 2019 Mar 16; 110(3):950-961. PubMed ID: 30648776
    [Abstract] [Full Text] [Related]

  • 13. Overexpression of IL-11 promotes premalignant gastric epithelial hyperplasia in isolation from germline gp130-JAK-STAT driver mutations.
    Buzzelli JN, O'Connor L, Scurr M, Chung Nien Chin S, Catubig A, Ng GZ, Oshima M, Oshima H, Giraud AS, Sutton P, Judd LM, Menheniott TR.
    Am J Physiol Gastrointest Liver Physiol; 2019 Feb 01; 316(2):G251-G262. PubMed ID: 30520693
    [Abstract] [Full Text] [Related]

  • 14. STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.
    Ernst M, Najdovska M, Grail D, Lundgren-May T, Buchert M, Tye H, Matthews VB, Armes J, Bhathal PS, Hughes NR, Marcusson EG, Karras JG, Na S, Sedgwick JD, Hertzog PJ, Jenkins BJ.
    J Clin Invest; 2008 May 01; 118(5):1727-38. PubMed ID: 18431520
    [Abstract] [Full Text] [Related]

  • 15. Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis.
    Jenkins BJ, Roberts AW, Greenhill CJ, Najdovska M, Lundgren-May T, Robb L, Grail D, Ernst M.
    Blood; 2007 Mar 15; 109(6):2380-8. PubMed ID: 17082315
    [Abstract] [Full Text] [Related]

  • 16. Epithelial gp130/Stat3 functions: an intestinal signaling node in health and disease.
    Ernst M, Thiem S, Nguyen PM, Eissmann M, Putoczki TL.
    Semin Immunol; 2014 Feb 15; 26(1):29-37. PubMed ID: 24434062
    [Abstract] [Full Text] [Related]

  • 17. Drug design targeting protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning: discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6/GP130 interface.
    Li H, Xiao H, Lin L, Jou D, Kumari V, Lin J, Li C.
    J Med Chem; 2014 Feb 13; 57(3):632-41. PubMed ID: 24456369
    [Abstract] [Full Text] [Related]

  • 18. Raloxifene inhibits pancreatic adenocarcinoma growth by interfering with ERβ and IL-6/gp130/STAT3 signaling.
    Pozios I, Seel NN, Hering NA, Hartmann L, Liu V, Camaj P, Müller MH, Lee LD, Bruns CJ, Kreis ME, Seeliger H.
    Cell Oncol (Dordr); 2021 Feb 13; 44(1):167-177. PubMed ID: 32940862
    [Abstract] [Full Text] [Related]

  • 19. Molecular pathways: IL11 as a tumor-promoting cytokine-translational implications for cancers.
    Ernst M, Putoczki TL.
    Clin Cancer Res; 2014 Nov 15; 20(22):5579-88. PubMed ID: 25074610
    [Abstract] [Full Text] [Related]

  • 20. Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.
    Jenkins BJ, Grail D, Nheu T, Najdovska M, Wang B, Waring P, Inglese M, McLoughlin RM, Jones SA, Topley N, Baumann H, Judd LM, Giraud AS, Boussioutas A, Zhu HJ, Ernst M.
    Nat Med; 2005 Aug 15; 11(8):845-52. PubMed ID: 16041381
    [Abstract] [Full Text] [Related]

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