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170 related items for PubMed ID: 30965668

  • 1. KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO⁻cGMP⁻MAPK Signaling Pathways.
    Lee ML, Sulistyowati E, Hsu JH, Huang BY, Dai ZK, Wu BN, Chao YY, Yeh JL.
    Molecules; 2019 Apr 08; 24(7):. PubMed ID: 30965668
    [Abstract] [Full Text] [Related]

  • 2. Inhibition of proinflammatory tumor necrosis factor-{alpha}-induced inducible nitric-oxide synthase by xanthine-based 7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1, 3-dimethylxanthine (KMUP-3) in rat trachea: The involvement of soluble guanylate cyclase and protein kinase G.
    Wu BN, Chen CW, Liou SF, Yeh JL, Chung HH, Chen IJ.
    Mol Pharmacol; 2006 Sep 08; 70(3):977-85. PubMed ID: 16754782
    [Abstract] [Full Text] [Related]

  • 3. KMUP-1 inhibits H441 lung epithelial cell growth, migration and proinflammation via increased NO/CGMP and inhibited RHO kinase/VEGF signaling pathways.
    Wu BN, Chen HY, Liu CP, Hsu LY, Chen IJ.
    Int J Immunopathol Pharmacol; 2011 Sep 08; 24(4):925-39. PubMed ID: 22230399
    [Abstract] [Full Text] [Related]

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  • 5. KMUP-1 attenuates isoprenaline-induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways.
    Yeh JL, Hsu JH, Wu PJ, Liou SF, Liu CP, Chen IJ, Wu BN, Dai ZK, Wu JR.
    Br J Pharmacol; 2010 Mar 08; 159(5):1151-60. PubMed ID: 20132211
    [Abstract] [Full Text] [Related]

  • 6. Cyclic guanosine monophosphate-enhancing reduces androgenic extracellular regulated protein kinases-phosphorylation/Rho kinase II-activation in benign prostate hyperplasia.
    Liu CM, Fan YC, Lo YC, Wu BN, Yeh JL, Chen IJ.
    Int J Urol; 2014 Jan 08; 21(1):87-92. PubMed ID: 23692571
    [Abstract] [Full Text] [Related]

  • 7. NO donor KMUP-1 improves hepatic ischemia-reperfusion and hypoxic cell injury by inhibiting oxidative stress and pro-inflammatory signaling.
    Kuo KK, Wu BN, Chiu EY, Tseng CJ, Yeh JL, Liu CP, Chai CY, Chen IJ.
    Int J Immunopathol Pharmacol; 2013 Jan 08; 26(1):93-106. PubMed ID: 23527712
    [Abstract] [Full Text] [Related]

  • 8. KMUP-1 attenuates serum deprivation-induced neurotoxicity in SH-SY5Y cells: roles of PKG, PI3K/Akt and Bcl-2/Bax pathways.
    Hsu YY, Liu CM, Tsai HH, Jong YJ, Chen IJ, Lo YC.
    Toxicology; 2010 Jan 31; 268(1-2):46-54. PubMed ID: 19962417
    [Abstract] [Full Text] [Related]

  • 9. A xanthine-based epithelium-dependent airway relaxant KMUP-3 (7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine) increases respiratory performance and protects against tumor necrosis factor-alpha-induced tracheal contraction, involving nitric oxide release and expression of cGMP and protein kinase G.
    Lin RJ, Wu BN, Lo YC, An LM, Dai ZK, Lin YT, Tang CS, Chen IJ.
    J Pharmacol Exp Ther; 2006 Feb 31; 316(2):709-17. PubMed ID: 16234412
    [Abstract] [Full Text] [Related]

  • 10. KMUP-1 regulates the vascular calcification in chronic renal failure by mediating NO/cGMP/PKG signaling pathway.
    Ren LS, Zhang L, Zhu D, Li T, Wang Q, Yuan XY, Hao LR.
    Life Sci; 2020 Jul 15; 253():117683. PubMed ID: 32315727
    [Abstract] [Full Text] [Related]

  • 11. Endothelial nitric oxide synthase-enhancing G-protein coupled receptor antagonist inhibits pulmonary artery hypertension by endothelin-1-dependent and endothelin-1-independent pathways in a monocrotaline model.
    Liu CP, Dai ZK, Huang CH, Yeh JL, Wu BN, Wu JR, Chen IJ.
    Kaohsiung J Med Sci; 2014 Jun 15; 30(6):267-78. PubMed ID: 24835346
    [Abstract] [Full Text] [Related]

  • 12. KMUP-1 Attenuates Endothelin-1-Induced Cardiomyocyte Hypertrophy through Activation of Heme Oxygenase-1 and Suppression of the Akt/GSK-3β, Calcineurin/NFATc4 and RhoA/ROCK Pathways.
    Liou SF, Hsu JH, Chen YT, Chen IJ, Yeh JL.
    Molecules; 2015 Jun 05; 20(6):10435-49. PubMed ID: 26056815
    [Abstract] [Full Text] [Related]

  • 13. Phosphodiesterase inhibitor KMUP-3 displays cardioprotection via protein kinase G and increases cardiac output via G-protein-coupled receptor agonist activity and Ca(2+) sensitization.
    Liu CP, Yeh JL, Liou SF, Wu BN, Chen IJ.
    Kaohsiung J Med Sci; 2016 Feb 05; 32(2):55-67. PubMed ID: 26944323
    [Abstract] [Full Text] [Related]

  • 14. Baicalein, an active component of Scutellaria baicalensis Georgi, prevents lysophosphatidylcholine-induced cardiac injury by reducing reactive oxygen species production, calcium overload and apoptosis via MAPK pathways.
    Chen HM, Hsu JH, Liou SF, Chen TJ, Chen LY, Chiu CC, Yeh JL.
    BMC Complement Altern Med; 2014 Jul 09; 14():233. PubMed ID: 25012390
    [Abstract] [Full Text] [Related]

  • 15. KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels.
    Wu BN, Lin RJ, Lo YC, Shen KP, Wang CC, Lin YT, Chen IJ.
    Br J Pharmacol; 2004 Aug 09; 142(7):1105-14. PubMed ID: 15237094
    [Abstract] [Full Text] [Related]

  • 16. The action of nitric oxide to enhance cell survival in chick cardiomyocytes is mediated through a cGMP and ERK1/2 pathway while p38 mitogen-activated protein kinase-dependent pathways do not alter cell death.
    Rabkin SW, Tsang MY.
    Exp Physiol; 2008 Jul 09; 93(7):834-42. PubMed ID: 18344257
    [Abstract] [Full Text] [Related]

  • 17. The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase.
    Chung HH, Dai ZK, Wu BN, Yeh JL, Chai CY, Chu KS, Liu CP, Chen IJ.
    Br J Pharmacol; 2010 Jun 09; 160(4):971-86. PubMed ID: 20590592
    [Abstract] [Full Text] [Related]

  • 18. cGMP-enhancing- and alpha1A/alpha1D-adrenoceptor blockade-derived inhibition of Rho-kinase by KMUP-1 provides optimal prostate relaxation and epithelial cell anti-proliferation efficacy.
    Liu CM, Lo YC, Wu BN, Wu WJ, Chou YH, Huang CH, An LM, Chen IJ.
    Prostate; 2007 Sep 15; 67(13):1397-410. PubMed ID: 17639498
    [Abstract] [Full Text] [Related]

  • 19. Inhaled KMUP-1 Prevents Allergic Pulmonary Vascular Inflammation and Remodeling via NO and Suppressed MMP-9 and ICAM-1/VCAM-1.
    Liu CP, Hsieh CH, Wu BN, Yeh JL, Dai ZK, Chai CY, Chen IJ.
    Inflamm Allergy Drug Targets; 2012 Aug 01; 11(4):251-61. PubMed ID: 22452605
    [Abstract] [Full Text] [Related]

  • 20. Geniposide Prevents Hypoxia/Reoxygenation-Induced Apoptosis in H9c2 Cells: Improvement of Mitochondrial Dysfunction and Activation of GLP-1R and the PI3K/AKT Signaling Pathway.
    Jiang YQ, Chang GL, Wang Y, Zhang DY, Cao L, Liu J.
    Cell Physiol Biochem; 2016 Aug 01; 39(1):407-21. PubMed ID: 27372651
    [Abstract] [Full Text] [Related]

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