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Journal Abstract Search

249 related items for PubMed ID: 31030415

  • 1. In Vitro Metabolism by Aldehyde Oxidase Leads to Poor Pharmacokinetic Profile in Rats for c-Met Inhibitor MET401.
    Zhang JW, Deng HB, Zhang CY, Dai JQ, Li Q, Zheng QG, Wan HX, Yu HP, He F, Xu YC, Zhao S, Zhang JYJ.
    Eur J Drug Metab Pharmacokinet; 2019 Oct; 44(5):669-680. PubMed ID: 31030415
    [Abstract] [Full Text] [Related]

  • 2. Metabolism of c-Met Kinase Inhibitors Containing Quinoline by Aldehyde Oxidase, Electron Donating, and Steric Hindrance Effect.
    Zhang JW, Xiao W, Gao ZT, Yu ZT, Zhang JYJ.
    Drug Metab Dispos; 2018 Dec; 46(12):1847-1855. PubMed ID: 30209037
    [Abstract] [Full Text] [Related]

  • 3. Case report of extensive metabolism by aldehyde oxidase in humans: pharmacokinetics and metabolite profile of FK3453 in rats, dogs, and humans.
    Akabane T, Tanaka K, Irie M, Terashita S, Teramura T.
    Xenobiotica; 2011 May; 41(5):372-84. PubMed ID: 21385103
    [Abstract] [Full Text] [Related]

  • 4. Cynomolgus monkey as a surrogate for human aldehyde oxidase metabolism of the EGFR inhibitor BIBX1382.
    Hutzler JM, Cerny MA, Yang YS, Asher C, Wong D, Frederick K, Gilpin K.
    Drug Metab Dispos; 2014 Oct; 42(10):1751-60. PubMed ID: 25035284
    [Abstract] [Full Text] [Related]

  • 5. Species-Specific Involvement of Aldehyde Oxidase and Xanthine Oxidase in the Metabolism of the Pyrimidine-Containing mGlu5-Negative Allosteric Modulator VU0424238 (Auglurant).
    Crouch RD, Blobaum AL, Felts AS, Conn PJ, Lindsley CW.
    Drug Metab Dispos; 2017 Dec; 45(12):1245-1259. PubMed ID: 28939686
    [Abstract] [Full Text] [Related]

  • 6. The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5.
    Morrison RD, Blobaum AL, Byers FW, Santomango TS, Bridges TM, Stec D, Brewer KA, Sanchez-Ponce R, Corlew MM, Rush R, Felts AS, Manka J, Bates BS, Venable DF, Rodriguez AL, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Emmitte KA, Daniels JS.
    Drug Metab Dispos; 2012 Sep; 40(9):1834-45. PubMed ID: 22711749
    [Abstract] [Full Text] [Related]

  • 7. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
    Kalgutkar AS, Hatch HL, Kosea F, Nguyen HT, Choo EF, McClure KF, Taylor TJ, Henne KR, Kuperman AV, Dombroski MA, Letavic MA.
    Biopharm Drug Dispos; 2006 Nov; 27(8):371-86. PubMed ID: 16944451
    [Abstract] [Full Text] [Related]

  • 8. Evaluation of Carbazeran 4-Oxidation and O 6-Benzylguanine 8-Oxidation as Catalytic Markers of Human Aldehyde Oxidase: Impact of Cytosolic Contamination of Liver Microsomes.
    Xie J, Saburulla NF, Chen S, Wong SY, Yap ZP, Zhang LH, Lau AJ.
    Drug Metab Dispos; 2019 Jan; 47(1):26-37. PubMed ID: 30337443
    [Abstract] [Full Text] [Related]

  • 9. Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach.
    Adusumalli S, Jamwal R, Obach RS, Ryder TF, Leggio L, Akhlaghi F.
    Drug Metab Dispos; 2019 Aug; 47(8):874-882. PubMed ID: 31182423
    [Abstract] [Full Text] [Related]

  • 10. Monoamine oxidase B oxidizes a novel multikinase inhibitor KW-2449 to its iminium ion and aldehyde oxidase further converts it to the oxo-piperazine form in human.
    Hosogi J, Ohashi R, Maeda H, Tashiro S, Fuse E, Yamamoto Y, Kuwabara T.
    Drug Metab Pharmacokinet; 2017 Oct; 32(5):255-264. PubMed ID: 28751116
    [Abstract] [Full Text] [Related]

  • 11. Aldehyde oxidase-dependent species difference in hepatic metabolism of fasudil to hydroxyfasudil.
    Mao Z, Wu Y, Li Q, Wang X, Liu Y, Di X.
    Xenobiotica; 2018 Feb; 48(2):170-177. PubMed ID: 28166443
    [Abstract] [Full Text] [Related]

  • 12. Species-specific metabolism of SGX523 by aldehyde oxidase and the toxicological implications.
    Diamond S, Boer J, Maduskuie TP, Falahatpisheh N, Li Y, Yeleswaram S.
    Drug Metab Dispos; 2010 Aug; 38(8):1277-85. PubMed ID: 20421447
    [Abstract] [Full Text] [Related]

  • 13. The Role of Aldehyde Oxidase in the Metabolic Clearance of Substituted Benzothiazoles.
    Teffera Y, Liu J, Krolikowski P, Zhao Z.
    Drug Metab Lett; 2021 Aug; 14(2):126-136. PubMed ID: 34818997
    [Abstract] [Full Text] [Related]

  • 14. Absorption, Distribution, Metabolism, and Excretion of Capmatinib (INC280) in Healthy Male Volunteers and In Vitro Aldehyde Oxidase Phenotyping of the Major Metabolite.
    Glaenzel U, Jin Y, Hansen R, Schroer K, Rahmanzadeh G, Pfaar U, Jaap van Lier J, Borell H, Meissner A, Camenisch G, Zhao S.
    Drug Metab Dispos; 2020 Oct; 48(10):873-885. PubMed ID: 32665418
    [Abstract] [Full Text] [Related]

  • 15. Oxidative metabolic pathway of lenvatinib mediated by aldehyde oxidase.
    Inoue K, Mizuo H, Kawaguchi S, Fukuda K, Kusano K, Yoshimura T.
    Drug Metab Dispos; 2014 Aug; 42(8):1326-33. PubMed ID: 24914245
    [Abstract] [Full Text] [Related]

  • 16. Refinement of In Vitro Methods for Identification of Aldehyde Oxidase Substrates Reveals Metabolites of Kinase Inhibitors.
    Dick RA.
    Drug Metab Dispos; 2018 Jun; 46(6):846-859. PubMed ID: 29615437
    [Abstract] [Full Text] [Related]

  • 17. Evaluation of Deuterium-Labeled JNJ38877605: Pharmacokinetic, Metabolic, and in Vivo Antitumor Profiles.
    Zhan Z, Peng X, Sun Y, Ai J, Duan W.
    Chem Res Toxicol; 2018 Nov 19; 31(11):1213-1218. PubMed ID: 30284817
    [Abstract] [Full Text] [Related]

  • 18. Human Aldehyde Oxidase 1-Mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes.
    Uehara S, Yoneda N, Higuchi Y, Yamazaki H, Suemizu H.
    Drug Metab Dispos; 2020 Jul 19; 48(7):580-586. PubMed ID: 32357972
    [Abstract] [Full Text] [Related]

  • 19. Hydralazine as a selective probe inactivator of aldehyde oxidase in human hepatocytes: estimation of the contribution of aldehyde oxidase to metabolic clearance.
    Strelevitz TJ, Orozco CC, Obach RS.
    Drug Metab Dispos; 2012 Jul 19; 40(7):1441-8. PubMed ID: 22522748
    [Abstract] [Full Text] [Related]

  • 20. Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity.
    Crouch RD, Morrison RD, Byers FW, Lindsley CW, Emmitte KA, Daniels JS.
    Drug Metab Dispos; 2016 Aug 19; 44(8):1296-303. PubMed ID: 26936972
    [Abstract] [Full Text] [Related]

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