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Journal Abstract Search

1034 related items for PubMed ID: 31051400

  • 1. Design, synthesis and anticancer evaluation of thieno[2,3-d]pyrimidine derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers.
    Elmetwally SA, Saied KF, Eissa IH, Elkaeed EB.
    Bioorg Chem; 2019 Jul; 88():102944. PubMed ID: 31051400
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis and anticancer evaluation of 1H-pyrazolo[3,4-d]pyrimidine derivatives as potent EGFRWT and EGFRT790M inhibitors and apoptosis inducers.
    Gaber AA, Bayoumi AH, El-Morsy AM, Sherbiny FF, Mehany ABM, Eissa IH.
    Bioorg Chem; 2018 Oct; 80():375-395. PubMed ID: 29986185
    [Abstract] [Full Text] [Related]

  • 3. New thieno[3,2-d]pyrimidine-based derivatives: Design, synthesis and biological evaluation as antiproliferative agents, EGFR and ARO inhibitors inducing apoptosis in breast cancer cells.
    Farghaly AM, AboulWafa OM, Baghdadi HH, Abd El Razik HA, Sedra SMY, Shamaa MM.
    Bioorg Chem; 2021 Oct; 115():105208. PubMed ID: 34365057
    [Abstract] [Full Text] [Related]

  • 4. Pyrazolo[3,4-d]pyrimidine-based dual EGFR T790M/HER2 inhibitors: Design, synthesis, structure-activity relationship and biological activity as potential antitumor and anticonvulsant agents.
    Lamie PF, El-Kalaawy AM, Abdel Latif NS, Rashed LA, Philoppes JN.
    Eur J Med Chem; 2021 Mar 15; 214():113222. PubMed ID: 33545637
    [Abstract] [Full Text] [Related]

  • 5. Design, Synthesis, biological Evaluation, and molecular docking studies of novel Pyrazolo[3,4-d]Pyrimidine derivative scaffolds as potent EGFR inhibitors and cell apoptosis inducers.
    Sherbiny FF, Bayoumi AH, El-Morsy AM, Sobhy M, Hagras M.
    Bioorg Chem; 2021 Nov 15; 116():105325. PubMed ID: 34507234
    [Abstract] [Full Text] [Related]

  • 6. Novel pyrazolo[3,4-d]pyrimidines: design, synthesis, anticancer activity, dual EGFR/ErbB2 receptor tyrosine kinases inhibitory activity, effects on cell cycle profile and caspase-3-mediated apoptosis.
    Maher M, Kassab AE, Zaher AF, Mahmoud Z.
    J Enzyme Inhib Med Chem; 2019 Dec 15; 34(1):532-546. PubMed ID: 30688116
    [Abstract] [Full Text] [Related]

  • 7. Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFRWT and EGFRT790M.
    Nasser AA, Eissa IH, Oun MR, El-Zahabi MA, Taghour MS, Belal A, Saleh AM, Mehany ABM, Luesch H, Mostafa AE, Afifi WM, Rocca JR, Mahdy HA.
    Org Biomol Chem; 2020 Oct 07; 18(38):7608-7634. PubMed ID: 32959865
    [Abstract] [Full Text] [Related]

  • 8. Design, synthesis and anticancer evaluation of new 4-anilinoquinoline-3-carbonitrile derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers.
    Zou M, Li J, Jin B, Wang M, Chen H, Zhang Z, Zhang C, Zhao Z, Zheng L.
    Bioorg Chem; 2021 Sep 07; 114():105200. PubMed ID: 34375195
    [Abstract] [Full Text] [Related]

  • 9. Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors.
    Sever B, Altıntop MD, Radwan MO, Özdemir A, Otsuka M, Fujita M, Ciftci HI.
    Eur J Med Chem; 2019 Nov 15; 182():111648. PubMed ID: 31493743
    [Abstract] [Full Text] [Related]

  • 10. Novel thienopyrimidine derivatives as dual EGFR and VEGFR-2 inhibitors: design, synthesis, anticancer activity and effect on cell cycle profile.
    Mghwary AE, Gedawy EM, Kamal AM, Abuel-Maaty SM.
    J Enzyme Inhib Med Chem; 2019 Dec 15; 34(1):838-852. PubMed ID: 30919701
    [Abstract] [Full Text] [Related]

  • 11. Discovery of new thieno[3,2-d]pyrimidine derivatives targeting EGFRL858R/T790M NSCLCs by the conformation constrained strategy.
    Chen Y, Yang L, Qiao H, Cheng Z, Xie J, Zhou W, Huang X, Jiang Y, Yu B, Zhao W.
    Eur J Med Chem; 2020 Aug 01; 199():112388. PubMed ID: 32402937
    [Abstract] [Full Text] [Related]

  • 12. Synthesis of Novel Thieno[2,3-d]pyrimidine Derivatives and Evaluation of Their Cytotoxicity and EGFR Inhibitory Activity.
    Adly ME, Gedawy EM, El-Malah AA, El-Telbany FA.
    Anticancer Agents Med Chem; 2018 Aug 01; 18(5):747-756. PubMed ID: 29366427
    [Abstract] [Full Text] [Related]

  • 13. 2-Anilinopyrimidine derivatives: Design, synthesis, in vitro anti-proliferative activity, EGFR and ARO inhibitory activity, cell cycle analysis and molecular docking study.
    AboulWafa OM, Daabees HMG, Badawi WA.
    Bioorg Chem; 2020 Jun 01; 99():103798. PubMed ID: 32247112
    [Abstract] [Full Text] [Related]

  • 14. Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors.
    Milik SN, Abdel-Aziz AK, Lasheen DS, Serya RAT, Minucci S, Abouzid KAM.
    Eur J Med Chem; 2018 Jul 15; 155():316-336. PubMed ID: 29902719
    [Abstract] [Full Text] [Related]

  • 15. Design, synthesis and biological evaluation of new series of hexahydroquinoline and fused quinoline derivatives as potent inhibitors of wild-type EGFR and mutant EGFR (L858R and T790M).
    Shaheen MA, El-Emam AA, El-Gohary NS.
    Bioorg Chem; 2020 Dec 15; 105():104274. PubMed ID: 33339080
    [Abstract] [Full Text] [Related]

  • 16. Design, Synthesis, In Silico and In Vitro Evaluation of Novel Pyrimidine Derivatives as EGFR Inhibitors.
    Matada GSP, Abbas N, Dhiwar PS, Basu R, Devasahayam G.
    Anticancer Agents Med Chem; 2021 Dec 15; 21(4):451-461. PubMed ID: 32698735
    [Abstract] [Full Text] [Related]

  • 17. Synthesis, EGFR Inhibition and Anti-cancer Activity of New 3,6-dimethyl-1-phenyl-4-(substituted-methoxy)pyrazolo[3,4-d] pyrimidine Derivatives.
    Bakr RB, Mehany ABM, Abdellatif KRA.
    Anticancer Agents Med Chem; 2017 Dec 15; 17(10):1389-1400. PubMed ID: 28270084
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and in vitro antitumor evaluation of new thieno[2,3-d]pyrimidine derivatives as EGFR and DHFR inhibitors.
    Fouad MM, Ghabbour HA, Shehata IA, El-Ashmawy MB.
    Bioorg Chem; 2024 Jul 15; 148():107401. PubMed ID: 38749115
    [Abstract] [Full Text] [Related]

  • 19. New pyrimidine and pyrazole-based compounds as potential EGFR inhibitors: Synthesis, anticancer, antimicrobial evaluation and computational studies.
    Othman IMM, Alamshany ZM, Tashkandi NY, Gad-Elkareem MAM, Anwar MM, Nossier ES.
    Bioorg Chem; 2021 Sep 15; 114():105078. PubMed ID: 34161878
    [Abstract] [Full Text] [Related]

  • 20. Design, synthesis and biological evaluation of thieno[3,2-d]pyrimidine derivatives containing aroyl hydrazone or aryl hydrazide moieties for PI3K and mTOR dual inhibition.
    Han Y, Tian Y, Wang R, Fu S, Jiang J, Dong J, Qin M, Hou Y, Zhao Y.
    Bioorg Chem; 2020 Nov 15; 104():104197. PubMed ID: 32927132
    [Abstract] [Full Text] [Related]

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