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145 related items for PubMed ID: 31074977

  • 1. Structural, Kinetic, and Mechanistic Analysis of an Asymmetric 4-Oxalocrotonate Tautomerase Trimer.
    Baas BJ, Medellin BP, LeVieux JA, de Ruijter M, Zhang YJ, Brown SD, Akiva E, Babbitt PC, Whitman CP.
    Biochemistry; 2019 Jun 04; 58(22):2617-2627. PubMed ID: 31074977
    [Abstract] [Full Text] [Related]

  • 2. Structural Basis for the Asymmetry of a 4-Oxalocrotonate Tautomerase Trimer.
    Medellin BP, Lancaster EB, Brown SD, Rakhade S, Babbitt PC, Whitman CP, Zhang YJ.
    Biochemistry; 2020 Apr 28; 59(16):1592-1603. PubMed ID: 32242662
    [Abstract] [Full Text] [Related]

  • 3. Kinetic and structural characterization of a heterohexamer 4-oxalocrotonate tautomerase from Chloroflexus aurantiacus J-10-fl: implications for functional and structural diversity in the tautomerase superfamily .
    Burks EA, Fleming CD, Mesecar AD, Whitman CP, Pegan SD.
    Biochemistry; 2010 Jun 22; 49(24):5016-27. PubMed ID: 20465238
    [Abstract] [Full Text] [Related]

  • 4. The 4-oxalocrotonate tautomerase family of enzymes: how nature makes new enzymes using a beta-alpha-beta structural motif.
    Whitman CP.
    Arch Biochem Biophys; 2002 Jun 01; 402(1):1-13. PubMed ID: 12051677
    [Abstract] [Full Text] [Related]

  • 5. Introduction of Asymmetry in the Fused 4-Oxalocrotonate Tautomerases.
    Erwin K, Moreno RY, Baas BJ, Zhang YJ, Whitman CP.
    Biochemistry; 2023 Aug 15; 62(16):2461-2471. PubMed ID: 37490761
    [Abstract] [Full Text] [Related]

  • 6. Evolution of enzymatic activity in the tautomerase superfamily: mechanistic and structural consequences of the L8R mutation in 4-oxalocrotonate tautomerase.
    Poelarends GJ, Almrud JJ, Serrano H, Darty JE, Johnson WH, Hackert ML, Whitman CP.
    Biochemistry; 2006 Jun 27; 45(25):7700-8. PubMed ID: 16784221
    [Abstract] [Full Text] [Related]

  • 7. Systematic screening for catalytic promiscuity in 4-oxalocrotonate tautomerase: enamine formation and aldolase activity.
    Zandvoort E, Baas BJ, Quax WJ, Poelarends GJ.
    Chembiochem; 2011 Mar 07; 12(4):602-9. PubMed ID: 21290551
    [Abstract] [Full Text] [Related]

  • 8. Kinetic and Structural Analysis of Two Linkers in the Tautomerase Superfamily: Analysis and Implications.
    Baas BJ, Medellin BP, LeVieux JA, Erwin K, Lancaster EB, Johnson WH, Kaoud TS, Moreno RY, de Ruijter M, Babbitt PC, Zhang YJ, Whitman CP.
    Biochemistry; 2021 Jun 08; 60(22):1776-1786. PubMed ID: 34019384
    [Abstract] [Full Text] [Related]

  • 9. Inactivation of 4-oxalocrotonate tautomerase by 2-oxo-3-pentynoate.
    Johnson WH, Czerwinski RM, Fitzgerald MC, Whitman CP.
    Biochemistry; 1997 Dec 16; 36(50):15724-32. PubMed ID: 9398301
    [Abstract] [Full Text] [Related]

  • 10. Crystal structure of 4-oxalocrotonate tautomerase inactivated by 2-oxo-3-pentynoate at 2.4 A resolution: analysis and implications for the mechanism of inactivation and catalysis.
    Taylor AB, Czerwinski RM, Johnson WH, Whitman CP, Hackert ML.
    Biochemistry; 1998 Oct 20; 37(42):14692-700. PubMed ID: 9778344
    [Abstract] [Full Text] [Related]

  • 11. Kinetic, stereochemical, and structural effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase.
    Harris TK, Czerwinski RM, Johnson WH, Legler PM, Abeygunawardana C, Massiah MA, Stivers JT, Whitman CP, Mildvan AS.
    Biochemistry; 1999 Sep 21; 38(38):12343-57. PubMed ID: 10493802
    [Abstract] [Full Text] [Related]

  • 12. The structural basis for the perturbed pKa of the catalytic base in 4-oxalocrotonate tautomerase: kinetic and structural effects of mutations of Phe-50.
    Czerwinski RM, Harris TK, Massiah MA, Mildvan AS, Whitman CP.
    Biochemistry; 2001 Feb 20; 40(7):1984-95. PubMed ID: 11329265
    [Abstract] [Full Text] [Related]

  • 13. Inactivation of 4-Oxalocrotonate Tautomerase by 5-Halo-2-hydroxy-2,4-pentadienoates.
    Stack TMM, Li W, Johnson WH, Zhang YJ, Whitman CP.
    Biochemistry; 2018 Feb 13; 57(6):1012-1021. PubMed ID: 29303557
    [Abstract] [Full Text] [Related]

  • 14. Kinetic and structural characterization of a cis-3-Chloroacrylic acid dehalogenase homologue in Pseudomonas sp. UW4: A potential step between subgroups in the tautomerase superfamily.
    LeVieux JA, Baas BJ, Kaoud TS, Davidson R, Babbitt PC, Zhang YJ, Whitman CP.
    Arch Biochem Biophys; 2017 Dec 15; 636():50-56. PubMed ID: 29111295
    [Abstract] [Full Text] [Related]

  • 15. Cloning, expression, and characterization of a cis-3-chloroacrylic acid dehalogenase: insights into the mechanistic, structural, and evolutionary relationship between isomer-specific 3-chloroacrylic acid dehalogenases.
    Poelarends GJ, Serrano H, Person MD, Johnson WH, Murzin AG, Whitman CP.
    Biochemistry; 2004 Jan 27; 43(3):759-72. PubMed ID: 14730981
    [Abstract] [Full Text] [Related]

  • 16. Kinetic, crystallographic, and mechanistic characterization of TomN: elucidation of a function for a 4-oxalocrotonate tautomerase homologue in the tomaymycin biosynthetic pathway.
    Burks EA, Yan W, Johnson WH, Li W, Schroeder GK, Min C, Gerratana B, Zhang Y, Whitman CP.
    Biochemistry; 2011 Sep 06; 50(35):7600-11. PubMed ID: 21809870
    [Abstract] [Full Text] [Related]

  • 17. Effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase on the pKa values of active site residues and on the pH dependence of catalysis.
    Czerwinski RM, Harris TK, Johnson WH, Legler PM, Stivers JT, Mildvan AS, Whitman CP.
    Biochemistry; 1999 Sep 21; 38(38):12358-66. PubMed ID: 10493803
    [Abstract] [Full Text] [Related]

  • 18. Kinetic and structural characterization of DmpI from Helicobacter pylori and Archaeoglobus fulgidus, two 4-oxalocrotonate tautomerase family members.
    Almrud JJ, Dasgupta R, Czerwinski RM, Kern AD, Hackert ML, Whitman CP.
    Bioorg Chem; 2010 Dec 21; 38(6):252-9. PubMed ID: 20709352
    [Abstract] [Full Text] [Related]

  • 19. The crystal structure of YdcE, a 4-oxalocrotonate tautomerase homologue from Escherichia coli, confirms the structural basis for oligomer diversity.
    Almrud JJ, Kern AD, Wang SC, Czerwinski RM, Johnson WH, Murzin AG, Hackert ML, Whitman CP.
    Biochemistry; 2002 Oct 08; 41(40):12010-24. PubMed ID: 12356301
    [Abstract] [Full Text] [Related]

  • 20. Identification and characterization of new family members in the tautomerase superfamily: analysis and implications.
    Huddleston JP, Burks EA, Whitman CP.
    Arch Biochem Biophys; 2014 Dec 15; 564():189-96. PubMed ID: 25219626
    [Abstract] [Full Text] [Related]

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