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158 related items for PubMed ID: 31243960

  • 21. The architecture of hydrogen and sulfur σ-hole interactions explain differences in the inhibitory potency of C-β-d-glucopyranosyl thiazoles, imidazoles and an N-β-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design.
    Kyriakis E, Karra AG, Papaioannou O, Solovou T, Skamnaki VT, Liggri PGV, Zographos SE, Szennyes E, Bokor É, Kun S, Psarra AG, Somsák L, Leonidas DD.
    Bioorg Med Chem; 2020 Jan 01; 28(1):115196. PubMed ID: 31767404
    [Abstract] [Full Text] [Related]

  • 22. Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site.
    Hampson LJ, Arden C, Agius L, Ganotidis M, Kosmopoulou MN, Tiraidis C, Elemes Y, Sakarellos C, Leonidas DD, Oikonomakos NG.
    Bioorg Med Chem; 2006 Dec 01; 14(23):7835-45. PubMed ID: 16908161
    [Abstract] [Full Text] [Related]

  • 23. C-Glucopyranosyl-1,2,4-triazol-5-ones: synthesis and inhibition of glycogen phosphorylase.
    Bokor É, Széles Z, Docsa T, Gergely P, Somsák L.
    Carbohydr Res; 2016 Jun 24; 429():128-34. PubMed ID: 26818133
    [Abstract] [Full Text] [Related]

  • 24. Synthesis of substituted 2-(β-D-glucopyranosyl)-benzimidazoles and their evaluation as inhibitors of glycogen phosphorylase.
    Bokor É, Szilágyi E, Docsa T, Gergely P, Somsák L.
    Carbohydr Res; 2013 Nov 15; 381():179-86. PubMed ID: 23419607
    [Abstract] [Full Text] [Related]

  • 25. Glucose-based spiro-oxathiazoles as in vivo anti-hyperglycemic agents through glycogen phosphorylase inhibition.
    Goyard D, Kónya B, Czifrák K, Larini P, Demontrond F, Leroy J, Balzarin S, Tournier M, Tousch D, Petit P, Duret C, Maurel P, Docsa T, Gergely P, Somsák L, Praly JP, Azay-Milhau J, Vidal S.
    Org Biomol Chem; 2020 Feb 07; 18(5):931-940. PubMed ID: 31922157
    [Abstract] [Full Text] [Related]

  • 26. N-(4-Substituted-benzoyl)-N'-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.
    Nagy V, Felföldi N, Kónya B, Praly JP, Docsa T, Gergely P, Chrysina ED, Tiraidis C, Kosmopoulou MN, Alexacou KM, Konstantakaki M, Leonidas DD, Zographos SE, Oikonomakos NG, Kozmon S, Tvaroška I, Somsák L.
    Bioorg Med Chem; 2012 Mar 01; 20(5):1801-16. PubMed ID: 22325154
    [Abstract] [Full Text] [Related]

  • 27. Synthesis, Kinetic and Conformational Studies of 2-Substituted-5-(β-d-glucopyranosyl)-pyrimidin-4-ones as Potential Inhibitors of Glycogen Phosphorylase.
    Mavreas KF, Neofytos DD, Chrysina ED, Venturini A, Gimisis T.
    Molecules; 2020 Nov 22; 25(22):. PubMed ID: 33266408
    [Abstract] [Full Text] [Related]

  • 28. Glycogen phosphorylase as a molecular target for type 2 diabetes therapy.
    Oikonomakos NG.
    Curr Protein Pept Sci; 2002 Dec 22; 3(6):561-86. PubMed ID: 12470212
    [Abstract] [Full Text] [Related]

  • 29. Synthesis of heterocyclic N-(β-D-glucopyranosyl)carboxamides for inhibition of glycogen phosphorylase.
    Kónya B, Docsa T, Gergely P, Somsák L.
    Carbohydr Res; 2012 Apr 01; 351():56-63. PubMed ID: 22365837
    [Abstract] [Full Text] [Related]

  • 30. Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase.
    Watson KA, Chrysina ED, Tsitsanou KE, Zographos SE, Archontis G, Fleet GW, Oikonomakos NG.
    Proteins; 2005 Dec 01; 61(4):966-83. PubMed ID: 16222658
    [Abstract] [Full Text] [Related]

  • 31. Glucose analog inhibitors of glycogen phosphorylases as potential antidiabetic agents: recent developments.
    Somsák L, Nagya V, Hadady Z, Docsa T, Gergely P.
    Curr Pharm Des; 2003 Dec 01; 9(15):1177-89. PubMed ID: 12769745
    [Abstract] [Full Text] [Related]

  • 32. Nanomolar Inhibitors of Glycogen Phosphorylase Based on β-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study.
    Bokor É, Kyriakis E, Solovou TGA, Koppány C, Kantsadi AL, Szabó KE, Szakács A, Stravodimos GA, Docsa T, Skamnaki VT, Zographos SE, Gergely P, Leonidas DD, Somsák L.
    J Med Chem; 2017 Nov 22; 60(22):9251-9262. PubMed ID: 28925695
    [Abstract] [Full Text] [Related]

  • 33. Inhibition of glycogen phosphorylase in the context of type 2 diabetes, with focus on recent inhibitors bound at the active site.
    Praly JP, Vidal S.
    Mini Rev Med Chem; 2010 Oct 22; 10(12):1102-26. PubMed ID: 20716051
    [Abstract] [Full Text] [Related]

  • 34. Binding of beta-D-glucopyranosyl bismethoxyphosphoramidate to glycogen phosphorylase b: kinetic and crystallographic studies.
    Chrysina ED, Kosmopoulou MN, Kardakaris R, Bischler N, Leonidas DD, Kannan T, Loganathan D, Oikonomakos NG.
    Bioorg Med Chem; 2005 Feb 01; 13(3):765-72. PubMed ID: 15653344
    [Abstract] [Full Text] [Related]

  • 35. van der Waals interactions govern C-β-d-glucopyranosyl triazoles' nM inhibitory potency in human liver glycogen phosphorylase.
    Kantsadi AL, Stravodimos GA, Kyriakis E, Chatzileontiadou DSM, Solovou TGA, Kun S, Bokor É, Somsák L, Leonidas DD.
    J Struct Biol; 2017 Jul 01; 199(1):57-67. PubMed ID: 28483603
    [Abstract] [Full Text] [Related]

  • 36. The binding of β-d-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: A new class of inhibitors.
    Alexacou KM, Tenchiu Deleanu AC, Chrysina ED, Charavgi MD, Kostas ID, Zographos SE, Oikonomakos NG, Leonidas DD.
    Bioorg Med Chem; 2010 Nov 15; 18(22):7911-22. PubMed ID: 20947361
    [Abstract] [Full Text] [Related]

  • 37. Synthesis, in vitro ADME profiling and in vivo pharmacological evaluation of novel glycogen phosphorylase inhibitors.
    Miao GX, Wang YD, Yan ZW, Zhang LY.
    Bioorg Med Chem Lett; 2020 Jul 15; 30(14):127117. PubMed ID: 32527535
    [Abstract] [Full Text] [Related]

  • 38. The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: synthesis, biochemical and biological assessment.
    Kantsadi AL, Manta S, Psarra AM, Dimopoulou A, Kiritsis C, Parmenopoulou V, Skamnaki VT, Zoumpoulakis P, Zographos SE, Leonidas DD, Komiotis D.
    Eur J Med Chem; 2012 Aug 15; 54():740-9. PubMed ID: 22770609
    [Abstract] [Full Text] [Related]

  • 39.
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  • 40. Multidisciplinary docking, kinetics and X-ray crystallography studies of baicalein acting as a glycogen phosphorylase inhibitor and determination of its' potential against glioblastoma in cellular models.
    Mathomes RT, Koulas SM, Tsialtas I, Stravodimos G, Welsby PJ, Psarra AG, Stasik I, Leonidas DD, Hayes JM.
    Chem Biol Interact; 2023 Sep 01; 382():110568. PubMed ID: 37277066
    [Abstract] [Full Text] [Related]

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