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103 related items for PubMed ID: 31255744

  • 1. Drug potency on inhibiting late Na+ current is sensitive to gating modifier and current region where drug effects were measured.
    Wu M, Tran PN, Sheng J, Randolph AL, Wu WW.
    J Pharmacol Toxicol Methods; 2019; 100():106605. PubMed ID: 31255744
    [Abstract] [Full Text] [Related]

  • 2. Contribution of the neuronal sodium channel NaV1.8 to sodium- and calcium-dependent cellular proarrhythmia.
    Bengel P, Ahmad S, Tirilomis P, Trum M, Dybkova N, Wagner S, Maier LS, Hasenfuß G, Sossalla S.
    J Mol Cell Cardiol; 2020 Jul; 144():35-46. PubMed ID: 32418916
    [Abstract] [Full Text] [Related]

  • 3. A multi-modal composition of the late Na+ current in human ventricular cardiomyocytes.
    Maltsev VA, Undrovinas AI.
    Cardiovasc Res; 2006 Jan; 69(1):116-27. PubMed ID: 16223473
    [Abstract] [Full Text] [Related]

  • 4. Recording of multiple ion current components and action potentials in human induced pluripotent stem cell-derived cardiomyocytes via automated patch-clamp.
    Mann SA, Heide J, Knott T, Airini R, Epureanu FB, Deftu AF, Deftu AT, Radu BM, Amuzescu B.
    J Pharmacol Toxicol Methods; 2019 Jan; 100():106599. PubMed ID: 31228558
    [Abstract] [Full Text] [Related]

  • 5. An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel.
    Crumb WJ, Vicente J, Johannesen L, Strauss DG.
    J Pharmacol Toxicol Methods; 2016 Jan; 81():251-62. PubMed ID: 27060526
    [Abstract] [Full Text] [Related]

  • 6. A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current.
    Yang PC, El-Bizri N, Romero L, Giles WR, Rajamani S, Belardinelli L, Clancy CE.
    J Mol Cell Cardiol; 2016 Oct; 99():151-161. PubMed ID: 27545042
    [Abstract] [Full Text] [Related]

  • 7. A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current.
    Yang PC, Song Y, Giles WR, Horvath B, Chen-Izu Y, Belardinelli L, Rajamani S, Clancy CE.
    J Physiol; 2015 Mar 15; 593(6):1429-42. PubMed ID: 25545172
    [Abstract] [Full Text] [Related]

  • 8. Contribution of sodium channel neuronal isoform Nav1.1 to late sodium current in ventricular myocytes from failing hearts.
    Mishra S, Reznikov V, Maltsev VA, Undrovinas NA, Sabbah HN, Undrovinas A.
    J Physiol; 2015 Mar 15; 593(6):1409-27. PubMed ID: 25772296
    [Abstract] [Full Text] [Related]

  • 9. Intracellular calcium attenuates late current conducted by mutant human cardiac sodium channels.
    Potet F, Beckermann TM, Kunic JD, George AL.
    Circ Arrhythm Electrophysiol; 2015 Aug 15; 8(4):933-41. PubMed ID: 26022185
    [Abstract] [Full Text] [Related]

  • 10. Gating of the late Na+ channel in normal and failing human myocardium.
    Undrovinas AI, Maltsev VA, Kyle JW, Silverman N, Sabbah HN.
    J Mol Cell Cardiol; 2002 Nov 15; 34(11):1477-89. PubMed ID: 12431447
    [Abstract] [Full Text] [Related]

  • 11. Evaluation of Possible Proarrhythmic Potency: Comparison of the Effect of Dofetilide, Cisapride, Sotalol, Terfenadine, and Verapamil on hERG and Native IKr Currents and on Cardiac Action Potential.
    Orvos P, Kohajda Z, Szlovák J, Gazdag P, Árpádffy-Lovas T, Tóth D, Geramipour A, Tálosi L, Jost N, Varró A, Virág L.
    Toxicol Sci; 2019 Apr 01; 168(2):365-380. PubMed ID: 30561737
    [Abstract] [Full Text] [Related]

  • 12. Chronic heart failure slows late sodium current in human and canine ventricular myocytes: implications for repolarization variability.
    Maltsev VA, Silverman N, Sabbah HN, Undrovinas AI.
    Eur J Heart Fail; 2007 Mar 01; 9(3):219-27. PubMed ID: 17067855
    [Abstract] [Full Text] [Related]

  • 13. Action potential changes associated with a slowed inactivation of cardiac voltage-gated sodium channels by KB130015.
    Macianskiene R, Bito V, Raeymaekers L, Brandts B, Sipido KR, Mubagwa K.
    Br J Pharmacol; 2003 Aug 01; 139(8):1469-79. PubMed ID: 12922934
    [Abstract] [Full Text] [Related]

  • 14. Assessing use-dependent inhibition of the cardiac Na(+/-) current (I(Na)) in the PatchXpress automated patch clamp.
    Penniman JR, Kim DC, Salata JJ, Imredy JP.
    J Pharmacol Toxicol Methods; 2010 Aug 01; 62(2):107-18. PubMed ID: 20601018
    [Abstract] [Full Text] [Related]

  • 15. Antiarrhythmic effect of IKr activation in a cellular model of LQT3.
    Diness JG, Hansen RS, Nissen JD, Jespersen T, Grunnet M.
    Heart Rhythm; 2009 Jan 01; 6(1):100-6. PubMed ID: 19121808
    [Abstract] [Full Text] [Related]

  • 16. Larger rate dependence of late sodium current in cardiac Purkinje cells: A potential link to arrhythmogenesis.
    Li W, Yu Y, Hou JW, Zhou ZW, Guo K, Zhang PP, Wang ZQ, Yan JH, Sun J, Zhou Q, Wang YP, Li YG.
    Heart Rhythm; 2017 Mar 01; 14(3):422-431. PubMed ID: 27915058
    [Abstract] [Full Text] [Related]

  • 17. Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease.
    Toischer K, Hartmann N, Wagner S, Fischer TH, Herting J, Danner BC, Sag CM, Hund TJ, Mohler PJ, Belardinelli L, Hasenfuss G, Maier LS, Sossalla S.
    J Mol Cell Cardiol; 2013 Aug 01; 61():111-22. PubMed ID: 23570977
    [Abstract] [Full Text] [Related]

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  • 20. Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes.
    Maltsev VA, Sabbah HN, Higgins RS, Silverman N, Lesch M, Undrovinas AI.
    Circulation; 1998 Dec 08; 98(23):2545-52. PubMed ID: 9843461
    [Abstract] [Full Text] [Related]

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