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Journal Abstract Search

135 related items for PubMed ID: 31322035

  • 1. The pharmacologic characterization of allosteric molecules: Gq protein activation.
    Bdioui S, Verdi J, Pierre N, Trinquet E, Roux T, Kenakin T.
    J Recept Signal Transduct Res; 2019 Apr; 39(2):106-113. PubMed ID: 31322035
    [Abstract] [Full Text] [Related]

  • 2. Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor.
    Mistry SN, Valant C, Sexton PM, Capuano B, Christopoulos A, Scammells PJ.
    J Med Chem; 2013 Jun 27; 56(12):5151-72. PubMed ID: 23718562
    [Abstract] [Full Text] [Related]

  • 3. Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor.
    Khajehali E, Valant C, Jörg M, Tobin AB, Conn PJ, Lindsley CW, Sexton PM, Scammells PJ, Christopoulos A.
    Biochem Pharmacol; 2018 Aug 27; 154():243-254. PubMed ID: 29777683
    [Abstract] [Full Text] [Related]

  • 4. 4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor.
    Mistry SN, Jörg M, Lim H, Vinh NB, Sexton PM, Capuano B, Christopoulos A, Lane JR, Scammells PJ.
    J Med Chem; 2016 Jan 14; 59(1):388-409. PubMed ID: 26624844
    [Abstract] [Full Text] [Related]

  • 5. Allosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking.
    Yeatman HR, Lane JR, Choy KH, Lambert NA, Sexton PM, Christopoulos A, Canals M.
    J Biol Chem; 2014 May 30; 289(22):15856-66. PubMed ID: 24753247
    [Abstract] [Full Text] [Related]

  • 6. An Approach to Discovering Novel Muscarinic M1 Receptor Positive Allosteric Modulators with Potent Cognitive Improvement and Minimized Gastrointestinal Dysfunction.
    Kurimoto E, Matsuda S, Shimizu Y, Sako Y, Mandai T, Sugimoto T, Sakamoto H, Kimura H.
    J Pharmacol Exp Ther; 2018 Jan 30; 364(1):28-37. PubMed ID: 29025977
    [Abstract] [Full Text] [Related]

  • 7. Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor.
    Abdul-Ridha A, Lane JR, Mistry SN, López L, Sexton PM, Scammells PJ, Christopoulos A, Canals M.
    J Biol Chem; 2014 Nov 28; 289(48):33701-11. PubMed ID: 25326383
    [Abstract] [Full Text] [Related]

  • 8. Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M1 Muscarinic Acetylcholine Receptors.
    van der Westhuizen ET, Spathis A, Khajehali E, Jörg M, Mistry SN, Capuano B, Tobin AB, Sexton PM, Scammells PJ, Valant C, Christopoulos A.
    Mol Pharmacol; 2018 Jul 28; 94(1):770-783. PubMed ID: 29691279
    [Abstract] [Full Text] [Related]

  • 9. 6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity.
    Jörg M, van der Westhuizen ET, Khajehali E, Burger WAC, White JM, Choy KHC, Tobin AB, Sexton PM, Valant C, Capuano B, Christopoulos A, Scammells PJ.
    ACS Chem Neurosci; 2019 Mar 20; 10(3):1099-1114. PubMed ID: 30547573
    [Abstract] [Full Text] [Related]

  • 10. Novel Fused Arylpyrimidinone Based Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor.
    Mistry SN, Lim H, Jörg M, Capuano B, Christopoulos A, Lane JR, Scammells PJ.
    ACS Chem Neurosci; 2016 May 18; 7(5):647-61. PubMed ID: 26891194
    [Abstract] [Full Text] [Related]

  • 11. Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles.
    Dallagnol JCC, Khajehali E, van der Westhuizen ET, Jörg M, Valant C, Gonçalves AG, Capuano B, Christopoulos A, Scammells PJ.
    J Med Chem; 2018 Apr 12; 61(7):2875-2894. PubMed ID: 29544056
    [Abstract] [Full Text] [Related]

  • 12. Positive Allosteric Modulation of the Muscarinic M1 Receptor Improves Efficacy of Antipsychotics in Mouse Glutamatergic Deficit Models of Behavior.
    Choy KH, Shackleford DM, Malone DT, Mistry SN, Patil RT, Scammells PJ, Langmead CJ, Pantelis C, Sexton PM, Lane JR, Christopoulos A.
    J Pharmacol Exp Ther; 2016 Nov 12; 359(2):354-365. PubMed ID: 27630144
    [Abstract] [Full Text] [Related]

  • 13. A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation.
    Canals M, Lane JR, Wen A, Scammells PJ, Sexton PM, Christopoulos A.
    J Biol Chem; 2012 Jan 02; 287(1):650-659. PubMed ID: 22086918
    [Abstract] [Full Text] [Related]

  • 14. Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation.
    Ma L, Seager MA, Wittmann M, Jacobson M, Bickel D, Burno M, Jones K, Graufelds VK, Xu G, Pearson M, McCampbell A, Gaspar R, Shughrue P, Danziger A, Regan C, Flick R, Pascarella D, Garson S, Doran S, Kreatsoulas C, Veng L, Lindsley CW, Shipe W, Kuduk S, Sur C, Kinney G, Seabrook GR, Ray WJ.
    Proc Natl Acad Sci U S A; 2009 Sep 15; 106(37):15950-5. PubMed ID: 19717450
    [Abstract] [Full Text] [Related]

  • 15. Restoring Agonist Function at a Chemogenetically Modified M1 Muscarinic Acetylcholine Receptor.
    Khajehali E, Bradley S, van der Westhuizen ET, Molloy C, Valant C, Finlayson L, Lindsley CW, Sexton PM, Tobin AB, Christopoulos A.
    ACS Chem Neurosci; 2020 Dec 16; 11(24):4270-4279. PubMed ID: 33196174
    [Abstract] [Full Text] [Related]

  • 16. Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity.
    Marlo JE, Niswender CM, Days EL, Bridges TM, Xiang Y, Rodriguez AL, Shirey JK, Brady AE, Nalywajko T, Luo Q, Austin CA, Williams MB, Kim K, Williams R, Orton D, Brown HA, Lindsley CW, Weaver CD, Conn PJ.
    Mol Pharmacol; 2009 Mar 16; 75(3):577-88. PubMed ID: 19047481
    [Abstract] [Full Text] [Related]

  • 17. G protein coupling and signaling pathway activation by m1 muscarinic acetylcholine receptor orthosteric and allosteric agonists.
    Thomas RL, Mistry R, Langmead CJ, Wood MD, Challiss RA.
    J Pharmacol Exp Ther; 2008 Nov 16; 327(2):365-74. PubMed ID: 18664591
    [Abstract] [Full Text] [Related]

  • 18. Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor.
    Abdul-Ridha A, López L, Keov P, Thal DM, Mistry SN, Sexton PM, Lane JR, Canals M, Christopoulos A.
    J Biol Chem; 2014 Feb 28; 289(9):6067-79. PubMed ID: 24443568
    [Abstract] [Full Text] [Related]

  • 19. The allosteric site regulates the voltage sensitivity of muscarinic receptors.
    Hoppe A, Marti-Solano M, Drabek M, Bünemann M, Kolb P, Rinne A.
    Cell Signal; 2018 Jan 28; 42():114-126. PubMed ID: 29056499
    [Abstract] [Full Text] [Related]

  • 20. SAR studies on carboxylic acid series M(1) selective positive allosteric modulators (PAMs).
    Kuduk SD, Beshore DC.
    Curr Top Med Chem; 2014 Jan 28; 14(15):1738-54. PubMed ID: 25176125
    [Abstract] [Full Text] [Related]

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