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Journal Abstract Search

468 related items for PubMed ID: 31332069

  • 1.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 2. Identification of New MmpL3 Inhibitors by Untargeted and Targeted Mutant Screens Defines MmpL3 Domains with Differential Resistance.
    Williams JT, Haiderer ER, Coulson GB, Conner KN, Ellsworth E, Chen C, Alvarez-Cabrera N, Li W, Jackson M, Dick T, Abramovitch RB.
    Antimicrob Agents Chemother; 2019 Oct; 63(10):. PubMed ID: 31405862
    [Abstract] [Full Text] [Related]

  • 3. SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis.
    Tahlan K, Wilson R, Kastrinsky DB, Arora K, Nair V, Fischer E, Barnes SW, Walker JR, Alland D, Barry CE, Boshoff HI.
    Antimicrob Agents Chemother; 2012 Apr; 56(4):1797-809. PubMed ID: 22252828
    [Abstract] [Full Text] [Related]

  • 4. A piperidinol-containing molecule is active against Mycobacterium tuberculosis by inhibiting the mycolic acid flippase activity of MmpL3.
    Dupont C, Chen Y, Xu Z, Roquet-Banères F, Blaise M, Witt AK, Dubar F, Biot C, Guérardel Y, Maurer FP, Chng SS, Kremer L.
    J Biol Chem; 2019 Nov 15; 294(46):17512-17523. PubMed ID: 31562241
    [Abstract] [Full Text] [Related]

  • 5. The crystal structure of the mycobacterial trehalose monomycolate transport factor A, TtfA, reveals an atypical fold.
    Ung KL, Alsarraf HMAB, Kremer L, Blaise M.
    Proteins; 2020 Jun 15; 88(6):809-815. PubMed ID: 31833106
    [Abstract] [Full Text] [Related]

  • 6. Active Benzimidazole Derivatives Targeting the MmpL3 Transporter in Mycobacterium abscessus.
    Raynaud C, Daher W, Johansen MD, Roquet-Banères F, Blaise M, Onajole OK, Kozikowski AP, Herrmann JL, Dziadek J, Gobis K, Kremer L.
    ACS Infect Dis; 2020 Feb 14; 6(2):324-337. PubMed ID: 31860799
    [Abstract] [Full Text] [Related]

  • 7. MmpL3 inhibitors as antituberculosis drugs.
    Shao M, McNeil M, Cook GM, Lu X.
    Eur J Med Chem; 2020 Aug 15; 200():112390. PubMed ID: 32447196
    [Abstract] [Full Text] [Related]

  • 8. Allosteric coupling of substrate binding and proton translocation in MmpL3 transporter from Mycobacterium tuberculosis.
    Babii S, Li W, Yang L, Grzegorzewicz AE, Jackson M, Gumbart JC, Zgurskaya HI.
    mBio; 2024 Oct 16; 15(10):e0218324. PubMed ID: 39212407
    [Abstract] [Full Text] [Related]

  • 9. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane.
    Grzegorzewicz AE, Pham H, Gundi VA, Scherman MS, North EJ, Hess T, Jones V, Gruppo V, Born SE, Korduláková J, Chavadi SS, Morisseau C, Lenaerts AJ, Lee RE, McNeil MR, Jackson M.
    Nat Chem Biol; 2012 Feb 19; 8(4):334-41. PubMed ID: 22344175
    [Abstract] [Full Text] [Related]

  • 10. HC2091 Kills Mycobacterium tuberculosis by Targeting the MmpL3 Mycolic Acid Transporter.
    Zheng H, Williams JT, Coulson GB, Haiderer ER, Abramovitch RB.
    Antimicrob Agents Chemother; 2018 Jul 19; 62(7):. PubMed ID: 29661875
    [Abstract] [Full Text] [Related]

  • 11. Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis.
    Li W, Upadhyay A, Fontes FL, North EJ, Wang Y, Crans DC, Grzegorzewicz AE, Jones V, Franzblau SG, Lee RE, Crick DC, Jackson M.
    Antimicrob Agents Chemother; 2014 Nov 19; 58(11):6413-23. PubMed ID: 25136022
    [Abstract] [Full Text] [Related]

  • 12. Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors.
    McNeil MB, O'Malley T, Dennison D, Shelton CD, Sunde B, Parish T.
    mSphere; 2020 Oct 14; 5(5):. PubMed ID: 33055263
    [Abstract] [Full Text] [Related]

  • 13. Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3.
    Li W, Obregón-Henao A, Wallach JB, North EJ, Lee RE, Gonzalez-Juarrero M, Schnappinger D, Jackson M.
    Antimicrob Agents Chemother; 2016 Sep 14; 60(9):5198-207. PubMed ID: 27297488
    [Abstract] [Full Text] [Related]

  • 14. Lipid transport in Mycobacterium tuberculosis and its implications in virulence and drug development.
    Bailo R, Bhatt A, Aínsa JA.
    Biochem Pharmacol; 2015 Aug 01; 96(3):159-67. PubMed ID: 25986884
    [Abstract] [Full Text] [Related]

  • 15. Acetylation of trehalose mycolates is required for efficient MmpL-mediated membrane transport in Corynebacterineae.
    Yamaryo-Botte Y, Rainczuk AK, Lea-Smith DJ, Brammananth R, van der Peet PL, Meikle P, Ralton JE, Rupasinghe TW, Williams SJ, Coppel RL, Crellin PK, McConville MJ.
    ACS Chem Biol; 2015 Mar 20; 10(3):734-46. PubMed ID: 25427102
    [Abstract] [Full Text] [Related]

  • 16. Structure-Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis.
    Belardinelli JM, Yazidi A, Yang L, Fabre L, Li W, Jacques B, Angala SK, Rouiller I, Zgurskaya HI, Sygusch J, Jackson M.
    ACS Infect Dis; 2016 Oct 14; 2(10):702-713. PubMed ID: 27737557
    [Abstract] [Full Text] [Related]

  • 17. Essentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression.
    Degiacomi G, Benjak A, Madacki J, Boldrin F, Provvedi R, Palù G, Kordulakova J, Cole ST, Manganelli R.
    Sci Rep; 2017 Feb 27; 7():43495. PubMed ID: 28240248
    [Abstract] [Full Text] [Related]

  • 18. Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria.
    Fay A, Czudnochowski N, Rock JM, Johnson JR, Krogan NJ, Rosenberg O, Glickman MS.
    mBio; 2019 Jun 25; 10(3):. PubMed ID: 31239378
    [Abstract] [Full Text] [Related]

  • 19. Targeting MmpL3 for anti-tuberculosis drug development.
    Bolla JR.
    Biochem Soc Trans; 2020 Aug 28; 48(4):1463-1472. PubMed ID: 32662825
    [Abstract] [Full Text] [Related]

  • 20. Mycobacterial Membrane Protein Large 3 (MmpL3) Inhibitors: A Promising Approach to Combat Tuberculosis.
    Umare MD, Khedekar PB, Chikhale RV.
    ChemMedChem; 2021 Oct 15; 16(20):3136-3148. PubMed ID: 34288519
    [Abstract] [Full Text] [Related]

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