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Journal Abstract Search

254 related items for PubMed ID: 31336309

  • 1. Rapid generation of novel benzoic acid-based xanthine derivatives as highly potent, selective and long acting DPP-4 inhibitors: Scaffold-hopping and prodrug study.
    Li Q, Meng L, Zhou S, Deng X, Wang N, Ji Y, Peng Y, Xing J, Yao G.
    Eur J Med Chem; 2019 Oct 15; 180():509-523. PubMed ID: 31336309
    [Abstract] [Full Text] [Related]

  • 2. Identification and structure-activity relationship exploration of uracil-based benzoic acid and ester derivatives as novel dipeptidyl Peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus.
    Li Q, Deng X, Jiang N, Meng L, Xing J, Jiang W, Xu Y.
    Eur J Med Chem; 2021 Dec 05; 225():113765. PubMed ID: 34399391
    [Abstract] [Full Text] [Related]

  • 3. Optimization of the benzamide fragment targeting the S2' site leads to potent dipeptidyl peptidase-IV inhibitors.
    Deng X, Wang N, Meng L, Zhou S, Huang J, Xing J, He L, Jiang W, Li Q.
    Bioorg Chem; 2020 Jan 05; 94():103366. PubMed ID: 31640932
    [Abstract] [Full Text] [Related]

  • 4. Design, synthesis and anti-diabetic activity of triazolotriazine derivatives as dipeptidyl peptidase-4 (DPP-4) inhibitors.
    Patel BD, Bhadada SV, Ghate MD.
    Bioorg Chem; 2017 Jun 05; 72():345-358. PubMed ID: 28302310
    [Abstract] [Full Text] [Related]

  • 5. The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119.
    Li G, Meng B, Yuan B, Huan Y, Zhou T, Jiang Q, Lei L, Sheng L, Wang W, Gong N, Lu Y, Ma C, Li Y, Shen Z, Huang H.
    Eur J Med Chem; 2020 Feb 15; 188():112017. PubMed ID: 31926470
    [Abstract] [Full Text] [Related]

  • 6. Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors.
    Li N, Wang LJ, Jiang B, Guo SJ, Li XQ, Chen XC, Luo J, Li C, Wang Y, Shi DY.
    Bioorg Med Chem Lett; 2018 Jul 01; 28(12):2131-2135. PubMed ID: 29773502
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and biological evaluation of triazole based uracil derivatives as novel DPP-4 inhibitors.
    Li Q, Han L, Zhang B, Zhou J, Zhang H.
    Org Biomol Chem; 2016 Oct 12; 14(40):9598-9611. PubMed ID: 27714283
    [Abstract] [Full Text] [Related]

  • 8. Discovery of triazole-based uracil derivatives bearing amide moieties as novel dipeptidyl peptidase-IV inhibitors.
    Deng X, Han L, Zhou J, Zhang H, Li Q.
    Bioorg Chem; 2017 Dec 12; 75():357-367. PubMed ID: 29096096
    [Abstract] [Full Text] [Related]

  • 9. Design, Synthesis and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel DPP-4 Inhibitors.
    Li Q, Zhou M, Han L, Cao Q, Wang X, Zhao L, Zhou J, Zhang H.
    Chem Biol Drug Des; 2015 Oct 12; 86(4):849-56. PubMed ID: 25787859
    [Abstract] [Full Text] [Related]

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  • 12. Synthesis and biological evaluation of xanthine derivatives on dipeptidyl peptidase 4.
    Lin K, Cai Z, Wang F, Zhang W, Zhou W.
    Chem Pharm Bull (Tokyo); 2013 Oct 12; 61(4):477-82. PubMed ID: 23358258
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  • 14. Discovery and Rational Design of Natural-Product-Derived 2-Phenyl-3,4-dihydro-2H-benzo[f]chromen-3-amine Analogs as Novel and Potent Dipeptidyl Peptidase 4 (DPP-4) Inhibitors for the Treatment of Type 2 Diabetes.
    Li S, Xu H, Cui S, Wu F, Zhang Y, Su M, Gong Y, Qiu S, Jiao Q, Qin C, Shan J, Zhang M, Wang J, Yin Q, Xu M, Liu X, Wang R, Zhu L, Li J, Xu Y, Jiang H, Zhao Z, Li J, Li H.
    J Med Chem; 2016 Jul 28; 59(14):6772-90. PubMed ID: 27396490
    [Abstract] [Full Text] [Related]

  • 15. Discovery of highly potent DPP-4 inhibitors by hybrid compound design based on linagliptin and alogliptin.
    Lai ZW, Li C, Liu J, Kong L, Wen X, Sun H.
    Eur J Med Chem; 2014 Aug 18; 83():547-60. PubMed ID: 24996141
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  • 17. Surrogating and redirection of pyrazolo[1,5-a]pyrimidin-7(4H)-one core, a novel class of potent and selective DPP-4 inhibitors.
    Deng X, Shen J, Zhu H, Xiao J, Sun R, Xie F, Lam C, Wang J, Qiao Y, Tavallaie MS, Hu Y, Du Y, Li J, Fu L, Jiang F.
    Bioorg Med Chem; 2018 Feb 15; 26(4):903-912. PubMed ID: 29373269
    [Abstract] [Full Text] [Related]

  • 18. Scaffold-based design of xanthine as highly potent inhibitors of DPP-IV for improving glucose homeostasis in DIO mice.
    Ran Y, Pei H, Xie C, Ma L, Wu Y, Lei K, Shao M, Tang M, Xiang M, Peng A, Wei Y, Chen L.
    Mol Divers; 2015 May 15; 19(2):333-46. PubMed ID: 25672287
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