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318 related items for PubMed ID: 31358898

  • 1. 23,24-Dihydrocucurbitacin B promotes lipid clearance by dual transcriptional regulation of LDLR and PCSK9.
    Li HH, Li J, Zhang XJ, Li JM, Xi C, Wang WQ, Lu YL, Xuan LJ.
    Acta Pharmacol Sin; 2020 Mar; 41(3):327-335. PubMed ID: 31358898
    [Abstract] [Full Text] [Related]

  • 2. Identification of neolignans with PCSK9 downregulatory and LDLR upregulatory activities from Penthorum chinense and the potential in cholesterol uptake by transcriptional regulation of LDLR via SREBP2.
    Chae HS, Pel P, Cho J, Kim YM, An CY, Huh J, Choi YH, Kim J, Chin YW.
    J Ethnopharmacol; 2021 Oct 05; 278():114265. PubMed ID: 34111537
    [Abstract] [Full Text] [Related]

  • 3. Welsh onion extract inhibits PCSK9 expression contributing to the maintenance of the LDLR level under lipid depletion conditions of HepG2 cells.
    Choi HK, Hwang JT, Nam TG, Kim SH, Min DK, Park SW, Chung MY.
    Food Funct; 2017 Dec 13; 8(12):4582-4591. PubMed ID: 29130084
    [Abstract] [Full Text] [Related]

  • 4. Activation of Adiponectin Receptor Regulates Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Inhibits Lesions in ApoE-Deficient Mice.
    Sun L, Yang X, Li Q, Zeng P, Liu Y, Liu L, Chen Y, Yu M, Ma C, Li X, Li Y, Zhang R, Zhu Y, Miao QR, Han J, Duan Y.
    Arterioscler Thromb Vasc Biol; 2017 Jul 13; 37(7):1290-1300. PubMed ID: 28546220
    [Abstract] [Full Text] [Related]

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  • 6. Enhanced pro-protein convertase subtilisin/kexin type 9 expression by C-reactive protein through p38MAPK-HNF1α pathway in HepG2 cells.
    Cui CJ, Li S, Zhu CG, Sun J, Du Y, Zhang Y, Wu NQ, Guo YL, Xu RX, Gao Y, Li JJ.
    J Cell Mol Med; 2016 Dec 13; 20(12):2374-2383. PubMed ID: 27633999
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  • 8. Endoplasmic Reticulum Stress and Ca2+ Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism.
    Lebeau P, Al-Hashimi A, Sood S, Lhoták Š, Yu P, Gyulay G, Paré G, Chen SR, Trigatti B, Prat A, Seidah NG, Austin RC.
    J Biol Chem; 2017 Jan 27; 292(4):1510-1523. PubMed ID: 27909053
    [Abstract] [Full Text] [Related]

  • 9. Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.
    Wang D, Yang X, Chen Y, Gong K, Yu M, Gao Y, Wu X, Hu H, Liao C, Han J, Duan Y.
    J Biol Chem; 2020 Nov 20; 295(47):15870-15882. PubMed ID: 32913121
    [Abstract] [Full Text] [Related]

  • 10. Peroxisome Proliferator-activated receptor γ activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression.
    Duan Y, Chen Y, Hu W, Li X, Yang X, Zhou X, Yin Z, Kong D, Yao Z, Hajjar DP, Liu L, Liu Q, Han J.
    J Biol Chem; 2012 Jul 06; 287(28):23667-77. PubMed ID: 22593575
    [Abstract] [Full Text] [Related]

  • 11. The Cholesterol-Modulating Effect of Methanol Extract of Pigeon Pea (Cajanus cajan (L.) Millsp.) Leaves on Regulating LDLR and PCSK9 Expression in HepG2 Cells.
    Chang HY, Wu JR, Gao WY, Lin HR, Chen PY, Chen CI, Wu MJ, Yen JH.
    Molecules; 2019 Jan 30; 24(3):. PubMed ID: 30704067
    [Abstract] [Full Text] [Related]

  • 12. Hepatic overexpression of idol increases circulating protein convertase subtilisin/kexin type 9 in mice and hamsters via dual mechanisms: sterol regulatory element-binding protein 2 and low-density lipoprotein receptor-dependent pathways.
    Sasaki M, Terao Y, Ayaori M, Uto-Kondo H, Iizuka M, Yogo M, Hagisawa K, Takiguchi S, Yakushiji E, Nakaya K, Ogura M, Komatsu T, Ikewaki K.
    Arterioscler Thromb Vasc Biol; 2014 Jun 30; 34(6):1171-8. PubMed ID: 24675665
    [Abstract] [Full Text] [Related]

  • 13. A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis.
    Wang WZ, Liu C, Luo JQ, Lei LJ, Chen MH, Zhang YY, Sheng R, Li YN, Wang L, Jiang XH, Xiao TM, Zhang YH, Li SW, Wu YX, Xu Y, Xu YN, Si SY.
    Acta Pharmacol Sin; 2024 Oct 30; 45(10):2119-2133. PubMed ID: 38811775
    [Abstract] [Full Text] [Related]

  • 14. Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters.
    Dong B, Wu M, Li H, Kraemer FB, Adeli K, Seidah NG, Park SW, Liu J.
    J Lipid Res; 2010 Jun 30; 51(6):1486-95. PubMed ID: 20048381
    [Abstract] [Full Text] [Related]

  • 15. Proprotein Convertase Subtilisin/Kexin-Type 9 and Lipid Metabolism.
    Guo S, Xia XD, Gu HM, Zhang DW.
    Adv Exp Med Biol; 2020 Jun 30; 1276():137-156. PubMed ID: 32705598
    [Abstract] [Full Text] [Related]

  • 16. MG132, a proteasome inhibitor, enhances LDL uptake in HepG2 cells in vitro by regulating LDLR and PCSK9 expression.
    Yan H, Ma YL, Gui YZ, Wang SM, Wang XB, Gao F, Wang YP.
    Acta Pharmacol Sin; 2014 Aug 30; 35(8):994-1004. PubMed ID: 25042549
    [Abstract] [Full Text] [Related]

  • 17. An Unbiased Mass Spectrometry Approach Identifies Glypican-3 as an Interactor of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR) in Hepatocellular Carcinoma Cells.
    Ly K, Essalmani R, Desjardins R, Seidah NG, Day R.
    J Biol Chem; 2016 Nov 18; 291(47):24676-24687. PubMed ID: 27758865
    [Abstract] [Full Text] [Related]

  • 18. Hepatic HNF1 transcription factors control the induction of PCSK9 mediated by rosuvastatin in normolipidemic hamsters.
    Dong B, Singh AB, Shende VR, Liu J.
    Int J Mol Med; 2017 Mar 18; 39(3):749-756. PubMed ID: 28204827
    [Abstract] [Full Text] [Related]

  • 19. Gypenoside LVI improves hepatic LDL uptake by decreasing PCSK9 and upregulating LDLR expression.
    Wang J, Wang YS, Huang YP, Jiang CH, Gao M, Zheng X, Yin ZQ, Zhang J.
    Phytomedicine; 2021 Oct 18; 91():153688. PubMed ID: 34380071
    [Abstract] [Full Text] [Related]

  • 20. Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance.
    Lebeau PF, Byun JH, Platko K, Saliba P, Sguazzin M, MacDonald ME, Paré G, Steinberg GR, Janssen LJ, Igdoura SA, Tarnopolsky MA, Wayne Chen SR, Seidah NG, Magolan J, Austin RC.
    Nat Commun; 2022 Feb 09; 13(1):770. PubMed ID: 35140212
    [Abstract] [Full Text] [Related]

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