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Journal Abstract Search

186 related items for PubMed ID: 31383553

  • 1. Bioavailability and cytosolic kinases modulate response to deoxynucleoside therapy in TK2 deficiency.
    Lopez-Gomez C, Hewan H, Sierra C, Akman HO, Sanchez-Quintero MJ, Juanola-Falgarona M, Tadesse S, Tanji K, Konofagou EE, Hirano M.
    EBioMedicine; 2019 Aug; 46():356-367. PubMed ID: 31383553
    [Abstract] [Full Text] [Related]

  • 2. Age-related metabolic changes limit efficacy of deoxynucleoside-based therapy in thymidine kinase 2-deficient mice.
    Blázquez-Bermejo C, Molina-Granada D, Vila-Julià F, Jiménez-Heis D, Zhou X, Torres-Torronteras J, Karlsson A, Martí R, Cámara Y.
    EBioMedicine; 2019 Aug; 46():342-355. PubMed ID: 31351931
    [Abstract] [Full Text] [Related]

  • 3. Deoxycytidine and Deoxythymidine Treatment for Thymidine Kinase 2 Deficiency.
    Lopez-Gomez C, Levy RJ, Sanchez-Quintero MJ, Juanola-Falgarona M, Barca E, Garcia-Diaz B, Tadesse S, Garone C, Hirano M.
    Ann Neurol; 2017 May; 81(5):641-652. PubMed ID: 28318037
    [Abstract] [Full Text] [Related]

  • 4. Basic biochemical characterization of cytosolic enzymes in thymidine nucleotide synthesis in adult rat tissues: implications for tissue specific mitochondrial DNA depletion and deoxynucleoside-based therapy for TK2-deficiency.
    Wang L, Sun R, Eriksson S.
    BMC Mol Cell Biol; 2020 Apr 28; 21(1):33. PubMed ID: 32345222
    [Abstract] [Full Text] [Related]

  • 5. Synergistic Deoxynucleoside and Gene Therapies for Thymidine Kinase 2 Deficiency.
    Lopez-Gomez C, Sanchez-Quintero MJ, Lee EJ, Kleiner G, Tadesse S, Xie J, Akman HO, Gao G, Hirano M.
    Ann Neurol; 2021 Oct 28; 90(4):640-652. PubMed ID: 34338329
    [Abstract] [Full Text] [Related]

  • 6. Onset and organ specificity of Tk2 deficiency depends on Tk1 down-regulation and transcriptional compensation.
    Dorado B, Area E, Akman HO, Hirano M.
    Hum Mol Genet; 2011 Jan 01; 20(1):155-64. PubMed ID: 20940150
    [Abstract] [Full Text] [Related]

  • 7. Recent advances in thymidine kinase 2 (TK2) inhibitors and new perspectives for potential applications.
    Priego EM, Karlsson A, Gago F, Camarasa MJ, Balzarini J, Pérez-Pérez MJ.
    Curr Pharm Des; 2012 Jan 01; 18(20):2981-94. PubMed ID: 22571666
    [Abstract] [Full Text] [Related]

  • 8. Tissue specific distribution of pyrimidine deoxynucleoside salvage enzymes shed light on the mechanism of mitochondrial DNA depletion.
    Wang L, Eriksson S.
    Nucleosides Nucleotides Nucleic Acids; 2010 Jun 01; 29(4-6):400-3. PubMed ID: 20544526
    [Abstract] [Full Text] [Related]

  • 9. Long term expression of Drosophila melanogaster nucleoside kinase in thymidine kinase 2-deficient mice with no lethal effects caused by nucleotide pool imbalances.
    Krishnan S, Paredes JA, Zhou X, Kuiper RV, Hultenby K, Curbo S, Karlsson A.
    J Biol Chem; 2014 Nov 21; 289(47):32835-44. PubMed ID: 25296759
    [Abstract] [Full Text] [Related]

  • 10. Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency.
    Garone C, Garcia-Diaz B, Emmanuele V, Lopez LC, Tadesse S, Akman HO, Tanji K, Quinzii CM, Hirano M.
    EMBO Mol Med; 2014 Aug 21; 6(8):1016-27. PubMed ID: 24968719
    [Abstract] [Full Text] [Related]

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  • 12. Preferent Diaphragmatic Involvement in TK2 Deficiency: An Autopsy Case Study.
    Laine-Menéndez S, Domínguez-González C, Blázquez A, Delmiro A, García-Consuegra I, Fernández-de la Torre M, Hernández-Laín A, Sayas J, Martín MÁ, Morán M.
    Int J Mol Sci; 2021 May 25; 22(11):. PubMed ID: 34070501
    [Abstract] [Full Text] [Related]

  • 13. Gene expression deregulation in postnatal skeletal muscle of TK2 deficient mice reveals a lower pool of proliferating myogenic progenitor cells.
    Paredes JA, Zhou X, Höglund S, Karlsson A.
    PLoS One; 2013 May 25; 8(1):e53698. PubMed ID: 23341978
    [Abstract] [Full Text] [Related]

  • 14. The kinetic effects on thymidine kinase 2 by enzyme-bound dTTP may explain the mitochondrial side effects of antiviral thymidine analogs.
    Wang L, Sun R, Eriksson S.
    Antimicrob Agents Chemother; 2011 Jun 25; 55(6):2552-8. PubMed ID: 21444706
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  • 16. Selective activation of deoxycytidine kinase by thymidine-5'-thiosulphate and release by deoxycytidine in human lymphocytes.
    Keszler G, Szikla K, Kazimierczuk Z, Spasokoukotskaja T, Sasvari-Szekely M, Staub M.
    Biochem Pharmacol; 2003 Feb 15; 65(4):563-71. PubMed ID: 12566083
    [Abstract] [Full Text] [Related]

  • 17. siRNA knockdown of mitochondrial thymidine kinase 2 (TK2) sensitizes human tumor cells to gemcitabine.
    Di Cresce C, Figueredo R, Rytelewski M, Maleki Vareki S, Way C, Ferguson PJ, Vincent MD, Koropatnick J.
    Oncotarget; 2015 Sep 08; 6(26):22397-409. PubMed ID: 26087398
    [Abstract] [Full Text] [Related]

  • 18. Deoxyribonucleoside kinases in mitochondrial DNA depletion.
    Saada-Reisch A.
    Nucleosides Nucleotides Nucleic Acids; 2004 Oct 08; 23(8-9):1205-15. PubMed ID: 15571232
    [Abstract] [Full Text] [Related]

  • 19. Hematopoiesis in the thymidine kinase 2 deficient mouse model of mitochondrial DNA depletion syndrome.
    Zhou X, Johansson M, Solaroli N, Rozell B, Grandien A, Karlsson A.
    J Inherit Metab Dis; 2010 Jun 08; 33(3):231-6. PubMed ID: 20440651
    [Abstract] [Full Text] [Related]

  • 20. Thymidine kinase 2 deficiency-induced mtDNA depletion in mouse liver leads to defect β-oxidation.
    Zhou X, Kannisto K, Curbo S, von Döbeln U, Hultenby K, Isetun S, Gåfvels M, Karlsson A.
    PLoS One; 2013 Jun 08; 8(3):e58843. PubMed ID: 23505564
    [Abstract] [Full Text] [Related]

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