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Journal Abstract Search

139 related items for PubMed ID: 31400708

  • 1. Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy.
    Jovanović M, Zhukovsky D, Podolski-Renić A, Domračeva I, Žalubovskis R, Senćanski M, Glišić S, Sharoyko V, Tennikova T, Dar'in D, Pešić M, Krasavin M.
    Eur J Med Chem; 2019 Nov 01; 181():111580. PubMed ID: 31400708
    [Abstract] [Full Text] [Related]

  • 2. Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent.
    Wang L, Yang Z, Fu J, Yin H, Xiong K, Tan Q, Jin H, Li J, Wang T, Tang W, Yin J, Cai G, Liu M, Kehr S, Becker K, Zeng H.
    Free Radic Biol Med; 2012 Mar 01; 52(5):898-908. PubMed ID: 22210352
    [Abstract] [Full Text] [Related]

  • 3. Further exploration of DVD-445 as a lead thioredoxin reductase (TrxR) inhibitor for cancer therapy: Optimization of potency and evaluation of anticancer potential.
    Jovanović M, Zhukovsky D, Podolski-Renić A, Žalubovskis R, Dar'in D, Sharoyko V, Tennikova T, Pešić M, Krasavin M.
    Eur J Med Chem; 2020 Apr 01; 191():112119. PubMed ID: 32087464
    [Abstract] [Full Text] [Related]

  • 4. Oxidation of structural cysteine residues in thioredoxin 1 by aromatic arsenicals enhances cancer cell cytotoxicity caused by the inhibition of thioredoxin reductase 1.
    Zhang X, Lu J, Ren X, Du Y, Zheng Y, Ioannou PV, Holmgren A.
    Free Radic Biol Med; 2015 Dec 01; 89():192-200. PubMed ID: 26169724
    [Abstract] [Full Text] [Related]

  • 5. Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors.
    Rackham O, Shearwood AM, Thyer R, McNamara E, Davies SM, Callus BA, Miranda-Vizuete A, Berners-Price SJ, Cheng Q, Arnér ES, Filipovska A.
    Free Radic Biol Med; 2011 Mar 15; 50(6):689-99. PubMed ID: 21172426
    [Abstract] [Full Text] [Related]

  • 6. A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis.
    Liu J, Mu C, Yue W, Li J, Ma B, Zhao L, Liu L, Chen Q, Yan C, Liu H, Hao X, Zhu Y.
    Free Radic Biol Med; 2013 Oct 15; 63():485-94. PubMed ID: 23732520
    [Abstract] [Full Text] [Related]

  • 7. Identification of phenazine analogue as a novel scaffold for thioredoxin reductase I inhibitors against Hep G2 cancer cell lines.
    Liao J, Wang L, Wu Z, Wang Z, Chen J, Zhong Y, Jiang F, Lu Y.
    J Enzyme Inhib Med Chem; 2019 Dec 15; 34(1):1158-1163. PubMed ID: 31179772
    [Abstract] [Full Text] [Related]

  • 8. Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure.
    Dagnell M, Pace PE, Cheng Q, Frijhoff J, Östman A, Arnér ESJ, Hampton MB, Winterbourn CC.
    J Biol Chem; 2017 Sep 01; 292(35):14371-14380. PubMed ID: 28684416
    [Abstract] [Full Text] [Related]

  • 9. Identification of Michael acceptor-centric pharmacophores with substituents that yield strong thioredoxin reductase inhibitory character correlated to antiproliferative activity.
    Gan FF, Kaminska KK, Yang H, Liew CY, Leow PC, So CL, Tu LN, Roy A, Yap CW, Kang TS, Chui WK, Chew EH.
    Antioxid Redox Signal; 2013 Oct 10; 19(11):1149-65. PubMed ID: 23311917
    [Abstract] [Full Text] [Related]

  • 10. Investigation of the effects of thiazole compounds on thioredoxin reductase 1 (TrxR1), glutathione S-transferase (GST), and glutathione reductase (GR) targeted human brain glioblastoma cancer (U-87 MG).
    Korkmaz IN.
    Biotechnol Appl Biochem; 2024 Aug 10; 71(4):948-959. PubMed ID: 38682343
    [Abstract] [Full Text] [Related]

  • 11. Design, synthesis, and biological evaluation of novel derivatives of dithiodiglycolic acid prepared via oxidative coupling of thiols.
    Bakulina O, Bannykh A, Jovanović M, Domračeva I, Podolski-Renić A, Žalubovskis R, Pešić M, Dar'in D, Krasavin M.
    J Enzyme Inhib Med Chem; 2019 Dec 10; 34(1):665-671. PubMed ID: 30746961
    [Abstract] [Full Text] [Related]

  • 12. Inhibitory nitrosylation of mammalian thioredoxin reductase 1: Molecular characterization and evidence for its functional role in cellular nitroso-redox imbalance.
    Engelman R, Ziv T, Arnér ESJ, Benhar M.
    Free Radic Biol Med; 2016 Aug 10; 97():375-385. PubMed ID: 27377780
    [Abstract] [Full Text] [Related]

  • 13. Thioredoxin Reductase Inhibition for Cancer Therapy.
    Gencheva R, Arnér ESJ.
    Annu Rev Pharmacol Toxicol; 2022 Jan 06; 62():177-196. PubMed ID: 34449246
    [Abstract] [Full Text] [Related]

  • 14. Acrolein-induced activation of mitogen-activated protein kinase signaling is mediated by alkylation of thioredoxin reductase and thioredoxin 1.
    Randall MJ, Spiess PC, Hristova M, Hondal RJ, van der Vliet A.
    Redox Biol; 2013 Jan 06; 1(1):265-75. PubMed ID: 24024160
    [Abstract] [Full Text] [Related]

  • 15. Design, synthesis and biological evaluations of diverse Michael acceptor-based phenazine hybrid molecules as TrxR1 inhibitors.
    Zhong Y, Liu J, Cheng X, Zhang H, Zhang C, Xia Z, Wu Z, Zhang L, Zheng Y, Gao Z, Jiang Z, Wang Z, Huang D, Lu Y, Jiang F.
    Bioorg Chem; 2021 Apr 06; 109():104736. PubMed ID: 33640630
    [Abstract] [Full Text] [Related]

  • 16. Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay.
    Prast-Nielsen S, Dexheimer TS, Schultz L, Stafford WC, Cheng Q, Xu J, Jadhav A, Arnér ES, Simeonov A.
    Free Radic Biol Med; 2011 May 01; 50(9):1114-23. PubMed ID: 21262347
    [Abstract] [Full Text] [Related]

  • 17. Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads.
    Kaminska KK, Bertrand HC, Tajima H, Stafford WC, Cheng Q, Chen W, Wells G, Arner ES, Chew EH.
    Oncotarget; 2016 Jun 28; 7(26):40233-40251. PubMed ID: 27244886
    [Abstract] [Full Text] [Related]

  • 18. Studies toward novel peptidomimetic inhibitors of thioredoxin-thioredoxin reductase system.
    Kłossowski S, Muchowicz A, Firczuk M, Swiech M, Redzej A, Golab J, Ostaszewski R.
    J Med Chem; 2012 Jan 12; 55(1):55-67. PubMed ID: 22128876
    [Abstract] [Full Text] [Related]

  • 19. EF24 induces ROS-mediated apoptosis via targeting thioredoxin reductase 1 in gastric cancer cells.
    Zou P, Xia Y, Chen W, Chen X, Ying S, Feng Z, Chen T, Ye Q, Wang Z, Qiu C, Yang S, Liang G.
    Oncotarget; 2016 Apr 05; 7(14):18050-64. PubMed ID: 26919110
    [Abstract] [Full Text] [Related]

  • 20. Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer.
    Zou P, Xia Y, Ji J, Chen W, Zhang J, Chen X, Rajamanickam V, Chen G, Wang Z, Chen L, Wang Y, Yang S, Liang G.
    Cancer Lett; 2016 May 28; 375(1):114-126. PubMed ID: 26963494
    [Abstract] [Full Text] [Related]

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